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   CT radiology
   CT anatomy
   Glossary of terms
   Clinical indications
   Systematic interpretation
   Head trauma
   Stroke
   Tumor
   Brain mets/tumor
   Infection/abscess
   Nodes/masses
   Pulmonary embolism
   Abdomen/pelvis
Patient A   Patient B
Note how the subdural bleed (left side) has compressed the ipsilateral
  ventricle resulting in a compensetory expansion of the contralateral
  ventricle.

Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
   Terms beginning with A – M
   Terms beginning with N - Z
   Amnesia                   Cistern(s)
                              Corpus callosum
   Arachnoid granulations    Dorsum Sellae
   Arachnoid membrane        Dura mater
   Basal ganglia             Falx cerebri
   Basilar Artery            Globus pallidus (see basal
                               ganglia)
   Calvarium                 Gyrus
   Caudate (see basal        Herniation
    ganglia)                  Insula/insullar ribbon
                              Internal capsule
   Cerebellum                Lentiform nuclei (see basal
   Cerebral cortex            ganglia)
   Choroid plexus            Medulla
                              Midbrain
   Circle of Willis
 Process where by increased intracranial pressure
  forces brain parenchyma through a fixed opening.
 Clinical scenarios:
     Transtentorial herniation (aka “uncal” herniation)
      ▪ Medial temporal lobes (uncus) and brainstem are forced through
        the tentorium
      ▪ Symptoms include headache, decreased consciousness, pupillary
        dilation and may progress to extensor posturing and death
     Cerebellar herniation (rare)
      ▪ Cerebellar tonsils are “pushed” into the foramen magnum
      ▪ Similar symptoms as transtentorial herniation
 The cerebrum is the largest part of the brain and is
  responsible for thought and abstraction.
 The cerebrum is divided in four “lobes”. Some
  authors include the insula as the fifth “lobe” of the
  cerebrum
 The outer layer of the cerebrum (cortex) is gray
  matter (lacks myelin)
   Anterograde amnesia = Loss of memory for an event
    or events immediately following a head injury.

   Retrograde amnesia = Loss of memory for an event or
    events preceeding a head injury.
   From the Greek        Arachnoid granulations
    arakhnoeid’s,
    (cobweblike)
   Villous projects of
    the pia-arachnoid
    membrane whose
    function is to
    absorb CSF and
    return it to the
    venous circulation
    via the superior
    saggital sinus.
 A thin membrane
  adherent to the dura
  mater.
 The arachnoid
  membrane is the middle
  layer of the three
  meningial layers (dura
  mater, arachnoid
  membrane, and pia
  mater) that surround the
  brain and spinal cord.
   The basasl ganglia consists of three gray matter
    structures (caudate, putamen, and globus pallidus)
    deep within cerebral hemispheres
     Lentiform nuclei = putamen and globus pallidus
   Functions as motor relay stations
   Pathology in the basal ganglia results in
    purposeless movements (Parkinson’s disease)
   The basilar artery provides blood to the posterior
    aspect of the Circle of Willis and is formed from the
    paired vertebral arteries. Supplies blood to the
    pons, cerebellum, and posterior cerebrum.
   The circle of Willis is a term used to describe
    the arterial supply for the brain. The circle is
    derived from the two internal carotid arteries
    as well as the basilar artery, the latter being
    the continuation of the two vertebral arteries.
Vertebral arteries
Vertebral arteries
   The bony
    “roof” of the
    skull; also know
    as the “skull
    cap”.
   The cerebellum is that portion of the brain that is
    involved with coordination of voluntary movement,
    balance, and muscle tone.
   Connects the brainstem with the forebrain and is
    involved in the control of sensory processing
   Ventricluar tissue (ependyma) that produces
    cerebral spinal fluid (CSF).
 From Latin (“box”).
 A well defined collection of CSF within the
  subarachnoid space (located between the pia and
  arachnoid membranes).
 Several cisterns are generally described and two
  are of importance in the CT head:
     Suprasellar - (Star-shaped) Location of the Circle of Willis
     Quadrigeminal - W-shaped at top of midbrain
   The corpus callosum is the structure that
    connects the left and right cerebral
    hemispheres.
   The dorsum sellae is the square shaped part of
    the sphenoid bone that forms the posterior
    boundary of the pitutary fossa.
Dorsum sellae
 Latin (“hard         Dura Mater   Epidural hematoma
               Brain
  mother”)
 The outer,
  fibrous
  portion of
  the
  meninges.
   A reflexion of the dura
    mater located between
    the cerebral
    hemispheres. Function
    is to provide support to
    the cerebral
    hemispheres.
   The rounded, elevated convolutions on the surfaces
    of the cerebral hemispheres.
   The insula is one of the
    five cerebral cortices
    (frontal, parietal,
    temporal, occipital,
    insular) and is located
    deep to the frontal,
    parietal, and temporal
    lobes. Function is to
    integrate autonomic
    functions.
   Collection of axons
    that carry sensory
    information to the
    cortex and motor
    information to the
    cord.
   The internal
    capsule is very
    sensitive to stroke
   Aka “medulla oblongata”
   Located in the brain stem and sits below the
    pons and in front of the cerebellum.
   Functions to help control autonomic function,
    especially heart rate and breathing.
   Includes the midbrain, pons, and medulla.
    Major function is survival (breathing,
    digestion, heart rate, blood pressure) and for
    arousal (being awake and alert).
 Occipital lobe           Septum pellucidum
 Parenchyma               Sulcus
 Parietal lobe            Suture(s)
 Pineal gland             Temporal lobe
 Pneumocephalus           Tentorium cerebelli
 Pons                     Thalamus
 Posterior fossa          Uncus
 Putamen (see globus      Ventricle(s)
  pallidus)
 Sagittal sinus
   Pneumocephalus (see
    red arrow) is the
    presence of air (or gas)
    within the cranial
    cavity and is usually
    associated with a
    basilar skull fracture
   The sutures are fibrous connections between
    bones of the skull
   Sutures allow for some flexibility of the
    cranium
   Fontanelles (aka “soft spots”) are unfused
    areas where sutures meet
   Sutures ossify at various times throughout
    life
   The pons sits between the brainstem and
    medulla
   Controls rate and depth of breathing
   Relays impulse from medulla to cerebrum
   Clinical pathology results in:
     Bilateral, fixed, pinpoint pupils (comatose patient)
     Cheyne-Stokes breathing
      ▪ Hyperventialtion followed by apnea
   The uncus is the medial (innermost) portion
    of the temporal lobe
   Under high intracranial pressure (ICP) the
    uncus can be involved in a transtentorial
    herniation syndrome
     ICP pushes the uncus through the tentorium
     cerebelli which results in compression of the
     brainstem
1. The brain squeezes under
   the falx cerebri in
   cingulate herniation
2. The brainstem herniates
   caudally
3. The uncus and the
   hippocampal gyrus
   herniate into the tentorial
   notch
4. The cerebellar tonsils
   herniate through the
   foramen magnum in
   tonsillar herniation
   The ventricles are CSF-containing cavities
   Provides a protective cushion (buoys the
    brain)
   CSF produced in roof of ventricles (choroid
    plexes)
   Circulation of CSF through ventricles and
    around the brain (subarachnoid space) and
    cord (central canal) with reabsorption in
    arachnoid villi
   The thalamus is the central relay station for
    sensory fibers (except olfactory)
   Cerebral cortex communicates with thalamus
   Responsible for primitive emotional responses
     Fear
     Pleasant vs. unpleasant stimuli
 The temporal lobes are one of the five cortical
  lobes
 The temporal lobes are responsible for hearing,
  speech, and some emotional and memory
  functions
   Lain – “groove” or “trench”
   Pleural – “sulci” (sul-sigh)
   The small cracks or dimples on the surface of the
    brain
   The septum
    pellucidum is a thin
    midline structural
    membrane
   The septum runs
    vertically between the
    lateral ventricles as
    well as inferiorly from
    the corpus callosum
 Aka “superior sagittal sinus”
 Large collection of venous blood above and behind the
  brain
 Attached to the falx cerebri
 Receives CSF from the arachnoid granulations
 The posterior fossa is an area within the intracranial
  cavity bound by the tentorium cerebelli above and
  foramen magnum below
 The posterior fossa contains the cerebellum and
  brainstem structures
   Aka “pineal body”
   The pineal glad is an endocrine gland that
    produces melatonin and is important in sleep-wake
    cycles
 The parietal lobe is the cortical lobe responsible for
  sensation (cutaneous and muscular)
 Responsible for integration of thoughts and
  feelings
   The functional tissue(s) (key elements) of an organ
 The occipital lobe is the cortical lobe responsible
  for vision
 Integration areas for visual images with sensory
  experiences.
 Dura matter (tentorium cerebelli) separates the
  occipital lobe from the cerebellum
   The putamen is part of the basasl ganglia
   The basals ganglia consists of three gray matter
    structures (caudate, putamen, and globus pallidus)
    deep within cerebral hemispheres
     Lentiform nuclei = putamen and globus pallidus
   Functions as motor relay stations
   Pathology in the basal ganglia results in
    purposeless movements (Parkinson’s disease)
 CT head is currently the procedure of choice for
  evaluation of suspected stroke
 Stokes are either hemorrhagic (minority) or
  nonhemorrhagic (vast majority of cases)
 Nonhemorrhagic strokes = “ischemic” strokes
     The latter, if diagnosed quickly, can (potentially) be
      treated with thrombolytic agents
     The CT can reliably serve to rule out intracranial
      hemorrhage
   The CT is examined for evidence of vascular
    occlusion (clots), edema, and hemorrhage
   General considerations
     Stroke anatomy
   Hemorrhagic CVA
   Nonhemorrhagic (ischemic) CVA
   Cerebral vascular supply (Circle of Willis)
   The motor and sensory Homunculus
   Arterial supply and brain function
   General considerations
   CT findings
   General considerations
   CT scan of hemorrhagic CVAs
     Basal ganglia location
     Cerebellar location
     Gross pathology of cortical CVA
Hypertensive hemorrhage
in the basil ganglia
   Hemorrhagic strokes are due to rupture of a
    cerebral blood vessel
     Bleeding can occur into or around the brain
     Blood may extend into the ventricular system
   Hemorrhagic strokes account for 16% of all
    strokes
     Hypertensive hemorrhage accounts for
     approximately 70-90% of non-traumatic primary
     intracerebral hemorrhages
 Etiologies include thrombus, embolism, or
  hypoperfusion
 Ischemic brain tissue becomes edematous
 Edematous tissue will appear hypodense on
  noncontrast CT
     Hypodensity begins as early as 1h post-CVA
      ▪ Earliest sign of CVA is loss of gray-white differentiation (the "insular
        ribbon" sign)
     Hypodensity is completely manifest by 12-24 hours post-
      CVA
   Obscuration of the lentiform nuclei
   Hypoattenuation of the insular ribbon
   Sulcal effacement and cortical hypodensity
   Hyperdense vessel signs
   Lentiform nuclei =
    globbus palladus and
    putamen (parts of the
    basal ganglia)
   Edema from ischemia
    produces hypodenity of
    basasl ganglia structures
    within hours of event
   Red arrows denotes
    hypodensity of the basal
    ganglia structures
    (compare to opposite
    side)
   An occluded vessel
    (thrombus) may
    appear ”dark” on CT
   The red arrow
    denotes a dense
    basilar artery
 Red arrows point to
  hypodensity and sulcal
  effacement.
 Note the generalized
  edematous appearance
  of the tissues within
  the middle cerebral
  artery distribution
 Moderate - severe head trauma is an indication for a
  CT head scan
 Some controversy exists as to when a CT should be
  obtained for a “minor” head injury in adults:
     Canadian CT recommendations
     New Orleans Criteria
   For infants and children:
     Considerations
     General recommendations
   Things to Think About
   Interpretation Mnemonics
   Order of Evaluation (basic)
     Bone windows
     Blood (intracranial hemorrhage)
     Brain parenchyma
     Ventricles
     Cisterns
   Introduction
   CT considerations and clinical importance
   Diagrams
     Ventricular anatomy
     CSF circulation
   CT images
     Normal lateral ventricles
     Normal third ventricle
     Ventriculomegaly
     Ventricular compression and enlargement
   Brain parenchyma = brain “tissue”
   The brain parenchyma is symmetrical
   Gray and white matter should be well defined
     Edema results in poor delineation
   Midline structures (falx cerebri, third and fourth
    ventricles) should not be deviated
     Deviated midline structures is evidence of mass effect =
      edema, bleeding, tumor
   Check the parenchyma for evidence of blood
   General considerations
   CT images
     Normal midline structures
     Midline shift
     Cerebral edema
   Notice the
    sharp
    difference
    between the
    large
    hypodense
    edematous
    (red arrows)
    tissue and the
    remaining
    “normal”
    cortical tissue
Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
   Noncontrast study is standard
     A contrast study will be so designated on the CT images
 Most scanners are now “ultrafast” and can perform a
  head CT in less than one minute
 Scan spans from the base of the occiput to the top of
  the vertex in 5-mm increments
 Three sets of data are derived from the primary scan:
     Bone windows (fractures)
     Tissue windows (gray/white matter density)
     Subdural windows (brain bleed)
 Evaluation of head trauma
  ▪ Cerebral hemorrhages
  ▪ Skull fracture
 Suspected cerebrovascular accident (CVA)
 Suspected brain tumor
 Hydrocephalus
   Clinical syndromes
   CT indications versus MRI
   Progressive headaches associated with:
     Vomiting (especially early AM)
     Behavior changes
CT                               MRI
   Fast, easy, available, and      Slower and more expensive
    relatively cheap                Soft tissue and joints
   Study of choice for             Spine and spinal cord
                                    Posterior fossa and orbits
    suspected brain bleed
                                    Better for CNS
   Generally good for solid         developmental
    organs and bleeds                applications
   Good study for chest,           Can’t be used with certain
    abdomen, and pelvis              pacemakers and (metal)
    pathology                        implants
   Radiation exposure
   Relative Density (Attenuation)
   Radiation Exposure
   CT protocols
     Noncontrast (“standard”)
     With contrast (“enhanced”)
   IV contrast – general considerations
   Clinical indications
   Contraindications
   I.V. contrast is given to differentiate blood vessels
    from soft tissue and organs
     Blood and falx appear white with contrast
   Original ionic contrast agents have largely been
    replaced with nonionic agents (fewer reactions)
     Iodine reactions were actually responses to the carrier
      molecule of the contrast rather than iodine
   Risk related to IV contrast:
     Anaphylaxis ~ 1:10,000
     Death ~ 1:40,000 – 100,000
   NPO X 4 hours before administration of IV
    contrast
     Depends on urgency of exam
   Quick
   Easy
   Available
   Inexpensive (fairly)
   Standard of care for closed head injury
    evaluation
     Shows bony calvarium well
       ▪ Bone windows can show fractures easily
“The five B’s”            “Blood Can Be Very Bad”
 Blood                    Blood = blood
 Brain                    Can = cisterns
 Bone                     Be = brain
 Balloons (ventricles)    Very = ventricles
 Boxes (cisterns)         Bad = bone
   Just like a standard X-ray, the CT shows
    dense objects (bone) as white and less dense
    objects (air) as black.
   The concept of relative density is known as
    attenuation and is measured in Hounsfield
    Units (HU)
Structure                  Hounsfield Units
 Bone                     + 1,000
 Blood                    + 50-100
 Gray matter              + 32 - 46
 White matter             + 22 - 36
 CSF                      + 4 - 10
 Water                    0
 Air                      -1,000
 Clincal caveat: The radioglogist can place the computer cursor
 on any part of the CT image and determine the exact HU
 density – a real time way to differentiate blood from abscess
 from CSF, etc.
   The CT scan is a sophisticated x-ray that
    literally takes a continuous x-ray as it moves
    around the patient (tomogram)
   The X-ray source and detector unit are
    situated opposite of each other
     360 degree movement around the patient
     Very thin x-ray beams are utilized
   The CT computer integrates the assembled x-
    ray information and produces a “relative
    density” map that we view as a gray-scale
    image.
Type of Exposure              Dosage (mSv)
 Background radiation        3 mSv/year
 CXR                         0.1 mSv
 CT head                     2 mSv
 CT chest                    8 mSv
 CT abdomen and pelvis       20mSv

 Caveat: A CT head is the equivalent of 20
 CXRs, while a CT abdomen & pelvis equals
 200 CXRs! Yikes!
   General considerations
   CT Description
   CT images
     Normal supracellar cistern
     Normal quadrigeminal cistern
     Compression of supracellar cistern (early)
Notice how the right uncus is pushing into the supracellar cistern.
Dx: Early uncal herniation from increased intracranial pressure
   From Latin (“box”)
   Collections of CSF within the subarachnoid space
    (between the pia and arachnoid membranes)
   Cistern pathology is usually seen on CT as
    compression or presence of blood
     Compression
       ▪ Increased intracranial pressure (herniation symndrome)
       ▪ Mass effect (tumor)
   Several cisterns are described but two are of
    importance in the CT head:
     Supracellar cistern
      ▪ Star-shaped (“super star”)
      ▪ Location = Circle of Willis
     Quadrigeminal cistern
      ▪ W-shaped (looks like a baby’s bottom)
      ▪ Location = Level of tentorium cerebelli
A. Falx Cerebri
B. Frontal Lobe
C. Anterior Horn of Lateral Ventricle
D. Third Ventricle
E. Quadrigemina Cistern
F. Cerebellum

 Can you visualize the
 “baby’s bottom”?
   Notice how the
    falx is deviated
    (white arrow)
    due to a space
    filling lesion
    (red outline)
   Developed from a series of patients ( > 16
    years-of-age) presenting with minor head
    injury (defined as GCS score of 13-15 after loss
    of consciousness, definite amnesia, or
    witnessed disorientation from trauma)
   Clinical criteria consist of five high-risk and
    two moderate-risk factors.
Obtain CT Head if patient has > one the following
  seven:
 GCS score lower than 15 two hours after injury
 Suspected open or depressed skull fracture
 Any sign of basal skull fracture
 Two or more episodes of vomiting
 Age 65 years or older
 Retrograde amnesia > 30 minutes
 Dangerous mechanism
   Motor vehicle involved
   Fall from a height of at least three ft or five stairs
   CT is needed if the patient > one of the following:
     Headache
     Vomiting
     Age older than 60 years
     Drug or alcohol intoxication
     Persistent anterograde amnesia (deficits in short-term memory)
     Visible trauma above the clavicle
     Seizure

    *Applicable for adults with a normal Glasgow Coma Scale score of 15 and blunt
    head trauma that occurred within the previous 24 hours that caused loss of
    consciousness, definite amnesia, or witnessed disorientation.
   Evaluate the significance of the injury by physical
    findings AND mechanism of injury
   Kids have heavy heads and weak necks
     Younger children are less likely to be symptomatic
   Signs of significant head injury can be subtle
    (persistent irritability)
   Scalp hematomas in infants and toddlers suggest
    significant injury
   All moderate and severe head trauma
   Any loss of consciousness
   Age under 3 months
       Skull fracture (intracranial injury in 15-30%)
       Scalp hematoma predicts fracture (>80% sensitivity)
   Depressed mental status
   Focal neurologic deficits
   Bulging fontanelle
   Persistent irritability after head injury
   Seizure following head injury
   Recurrent vomiting after injury
   Bone windows for fractures
   Brain tissue
     Hemorrhage or masses
     Symmetry
     Midline shift
     Edema
   Ventricles
     Compression, blood, or hydrocephalus
   Subarachnoid cistern compression
   The head contains four things (skull, brain,
    blood, spinal fluid)
     The CT is reviewed to make sure all four are in the
      right amount and location
   The brain is symmetrical; asymmetry is
    abnormal
   The cerebral hemispheres are mirror image
    structures - what is on the left should be on
    the right
   Prior contrast reaction (“iodine allergy”)
   Poor renal function
     Creatinine > 2.0
   Lack of consent
   Suspend breast feedings for 24 hours
    following I.V. contrast

    Shellfish and/or Betadyne allergies
    are not contraindications
A. Orbit
                                                                        B. Sphenoid Sinus
                                                                        C. Temporal Lobe
                                                                        D. External Auditory Canal
     A. Orbit                                                        E. E. Mastoid Air Cells
                                                                        Mastoid Air Cells
     B. Sphenoid Sinus                                               F. F. Cerebellar Hemisphere
                                                                        Cerebellar Hemisphere
     C. Temporal Lobe
     D. External Auditory Canal
Used with permission University of Virginia Health Sciences Center
A. Frontal Lobe
B. Frontal Bone
(Superior Surface of Orbit)
C. Dorsum Sellae
D. Basilar Artery
E. Temporal Lobe
F. Mastoid Air Cells
G. Cerebellar Hemisphere
A. Frontal Lobe
                                                                     B. Sylvian Fissure
                                                                     C. Temporal Lobe
                                                                     D. Suprasellar Cistern
                                                                     E. Midbrain
                                                                     F. Fourth Ventricle
                                                                     G. Cerebellar Hemisphere



Used with permission University of Virginia Health Sciences Center
A. Frontal Lobe
                                                                     B. Falx Cerebri
                                                                     C. Anterior Horn of Lateral
                                                                        Ventricle
                                                                     D. Third Ventricle
                                                                     E. Quadrigeminal Plate
                                                                        Cistern
                                                                     F. Cerebellum
Used with permission University of Virginia Health Sciences Center
A. Anterior Horn of the Lateral Ventricle
                                                                 B. Caudate Nucleus
                                                                 C. Anterior Limb of the Internal Capsule
                                                                 D. Putamen and Globus Pallidus
                                                                 E. Posterior Limb of the Internal Capsule
                                                                 F. Third Ventricle
                                                                 G. Quadrigeminal Plate Cistern
                                                                 H. Cerebellar Vermis
                                                                 I. Occipital Lobe

Used with permission University of Virginia Health Sciences Center
A. Genu of the Corpus Callosum
                                                                     B. Anterior Horn of the Lateral Ventricle
                                                                     C. Internal Capsule
                                                                     D. Thalamus
                                                                     E. Pineal Gland
                                                                     F. Choroid Plexus
                                                                     G. Straight Sinus

Used with permission University of Virginia Health Sciences Center
A. Falx Cerebri
                                                                     B. Frontal Lobe
                                                                     C. Body of the Lateral Ventricle
                                                                     D. Splenium of the Corpus Callosum
                                                                     E. Parietal Lobe
                                                                     F. Occipital Lobe
                                                                     G. Superior Sagittal Sinus

Used with permission University of Virginia Health Sciences Center
A. Falx Cerebri
                                                                     B. Sulcus
                                                                     C. Gyrus
                                                                     D. Superior Sagittal Sinus



Used with permission University of Virginia Health Sciences Center
Supracellar cisterrn
                   (can you visualize the “star” shape)




Fourth Ventricle
                   F = frontal lobes
                   U = uncus (medial temporal lobes)
                   Po = Pons
Dura (retracted)
                   Bridging vein(s)
Subdural bleed
1 - Anterior Fossa
2- Posterior Fossa
3- Frontal Sinus
4- Esphenoid Sinus
5- Tentorium Cerebelli
   Majority are due to aneurysms or
    arterioventricular malformations (AVM)
   Bleeding is into the CSF space
   Ability to diagnose with CT decreases with
    time:
     ▪ 95% positive at 12 hours
     ▪ 80% positive at 3 days
     ▪ 30% positive at two weeks
Berry aneurysm
   Below the dura but above the arachnoid
   Usually venous in origin
     Commonly a ruptured bridging vein (dural drainage)
     Cresent or sickle shaped pattern on CT
   Can cross suture lines
   Common in elderly or anti-coagulated
   Density of blood determines the age of the bleed:
     Acute
     Chronic
   aka “intracerebral” hemorrhage
   Can follow hypertensive stroke
   Can follow deceleration (“contusion”) injuries
   Can extend into the ventricles (intracerebral
    extension)
   Hemorrhage into the ventricular system
   Can be an extension of an intraparenchymal
    or subarachnoid bleed
   Can be secondary to trauma (poor outcome)
   Not uncommon in extremely premature
    infants
   Obstructive hydrocephalus can be a
    complication
   Arterial blood
     Usually secondary to a linear skull fracture through an arterial
      channel (like the middle meningeal artery)
   Biconvex shape (lens shaped)
   Bleeding may cross the midline
   Bleeding won’t cross suture lines
   A subdural and an epidural may occur together
   Epi vs. sub doesn’t matter – but volume does
     > 5 mm or > 10 mm in adults = surgical evacuation
Early ICP Findings       Late ICP Findings
 Headache                  Cushings triad
 Vomiting                    Hypertension
 Vision distortion
                              Bradycardia
 Decreased sensorium
 Papilledema possible
                          Flexor/extensor
                           posturing
                          Pupillary dysfunction
   Haydel MJ, Preston CA, Mills TJ, Luber S,
    Blaudeau E, DeBlieux PM. Indications for
    computed tomography in patients with minor
    head injury. N Engl J Med. 2000;343:100-5.
   Stiell IG, et al. Comparison of the Canadian
    CT Head Rule and the New Orleans Criteria in
    patients with minor head injury. JAMA.
    2005;294:1511-8.
   www.aafp.org/online/en/home/clinical/clinica
    lrecs/headinjurychild.html
   Basic properties
   Skull fractures
   Suture lines versus fracture lines
   Basilar skull fracture
   Child abuse and skull fractures
 Fracture in any
  location other than
  parietal location
 Non-linear fracture
 Linear fracture length
  exceeding 6 cm
 Fracture crossing
  suture lines
 The bone windows information is part of the routine CT
  head and is ideal for viewing fractures
 Sinuses can be seen well with bone windows
 The scout film of the CT scan is roughly the equivalent of
  a lateral skull x-ray film – so look at it too
 Remember to look at the overlying soft tissue for
  swelling as it may point to an underlying skull fracture
   Skull fractures may be classified as either linear or
    comminuted
     Inwardly displaced comminuted = depressed skull fx
        ▪ A depressed skull fracture requires immediate neurosurgical
          evaluation
   Cranial sutures can be confused with linear fractures
Suture                             Fracture
 Characteristic locations           Usually
                                     temperoparietal

   Symmetrical line on other side   Asymmetrical

   Same size throughout             Widest at the center/
                                     narrow at the end

   Graceful curvy lines             Straight lines with
                               angular turns
   A fracture of the orbital roof, sphenoid bone,
    or mastoid portion of temporal bone
   Usually resolve on their own but can be:
     Displaced
     Cranial nerve damage (II, VII, VIII)
     CSF leak (otorhea or rhinorhea)
   “Classic” clinical findings may (or may not) be
    present
   Hemotympanum
   Periorbital bruising ("raccoon eyes“)
   Cerebrospinal fluid otorrhea or rhinorrhea
   Battle's sign (Mastoid eccymoses)
   Pneumocephalus
     (Air and fluid/levels in sinuses)
   Superior to inferior
     Falx cerebri
     Body of lateral ventricles
     Internal capsule and thalamus
     Caudate and third ventricle
     3rd Ventricle and quadrigeminal cistern
     Supracellar cistern and 4th ventricle
Extra-axial hemorrhage               Intra-axial hemorrhage
(outside the brain)                  (inside the brain)
                                        Subarachnoid (SAH)
   Epidural
                                          Below the arachnoid membrane
     Below the skull
                                          On the surface of the brain
     “above” the dura                  Intraparenchymal (IPH)
   Subdural                              Within the substance of the
     Below the dura                       brain
     Above the thin, spidery-like      Intraventricular (IVH)
      arachnoid membrane                  Within the ventricles
   CSF-filled balloons          CSF Direction of Flow:
   CSF is produced in the         Lateral ventricles
    choroid plexes,                Foramen of Monroe
    “circulates” through           Third ventricle
    the ventricular system,        Cerebral aqueduct
    percolates over the            Fourth ventricle
    surface of the cord and        Foramen (Magendie and
    brain, and is absorbed          Lushka)
    in the arachnoid               Subarachnoid space
    granulations                   Arachnoid granulations
                                   Venous circulation
   Size
     Large = too much fluid or brain atrophy
     Small = Compression (edema or mass)
   Symmetry
     Asymmetry = impingement from mass/edema, etc.
   Presence of blood
     IVH can lead to secondary hydrocephalus
   Anatomic landmarks
     Lateral and 3rd ventricle are supratentorial
      ▪ 3rd is located anterior to the pineal gland
      ▪ Looks like an exclamation point
     4th ventricle is infratentorial
      ▪ Looks like a pith helmet (roundish)
   Considerations
   Ventricular system
   CSF circulation
   CT images:
     Hydrocephalus
     Asymmetry (impingement from tumor)
     IVH
   A tough, fibrous structure separating the
    cerebrum above and the cerebellum and
    brain stem below
   Provides support for the cerebrum
   Structures above the tentorium are known as
    supratentorial or anterior fossa
   Structures below the tentorium are known as
    infratentorial or posterior fossa
1 - Anterior Fossa
2- Posterior Fossa
3- Frontal Sinus
4- Esphenoid Sinus
5- Tentorium Cerebelli
Frontal   Parietal   Occipital   Temporal
Note collection of blood above the dura mater




                    Dura mater
Ruptured berry aneurysm
   Majority can be visualized without contrast
     Contrast is indicated if brain tumor is suspected and
     not see on noncontrast study
   Appear as edematous, low density, poorly-
    defined lesions
   Classified as intraaxial (within the brain tissue) or
    extraaxial
   Adult tumors are usually supratentorial while
    pediatric tumors are usually infratentorial
   Many metastatic tumors will be located at the
    gray-white matter border(s)
   General considerations
   Brain tumors
     Meningioma
     Astrocytoma (pediatric)
 Cystic mass in the
  midline of the
  cerebellum (red
  arrows)
 Note early
  hydrocephalic
  changes
  secondary to
  tumor
  compression
  (yellow arrows)
    Red arrow
                                                                     points to a
                                                                     large
                                                                     cerebellar
                                                                     hemorrhage




Used with permission University of Virginia Health Sciences Center
   Cocaine induced
                                                hypertensive CVA
                                               Note the large
                                                hemorrhagic lesion
                                                in the left cortical
                                                area as well as
                                                multiple smaller
                                                regions (redness)
                                                near the
                                                hippocampus and
                                                other cortical
                                                regions.

www.utsa.edu/tsi/assign/anat/neuropat.htm
 Loss of the gray-
  white interface in
  the lateral margins
  of the insula
 The cortex of the left
  insular ribbon is not
  visualized (arrow).
 Right insular ribbon
  is outlined in yellow
   Contrast enhanced CT
    of meningioma (most
    common extraxial
    brain tumor)
Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
A. Falx Cerebri
                                                            B. Frontal Lobe
                                                            C. Body of the Lateral
                                                            Ventricle
                                                            D. Splenium of the Corpus
                                                            Callosum
                                                            E. Parietal Lobe
                                                            F. Occipital Lobe
                                                            G. Superior Sagittal Sinus


Used with permission University of Virginia Health Sciences Center
Edema
                                                                      The darker gray
                     Edema
                                                                       areas represent
                              Blood
                      Blood                                            edema while the
                                                                       white areas
                                                                       represent the
                                                                       intracerebral
                                                                       contrusion
                                                                       (“bruise”)


Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
   Small red arrows point
                                                     to a biconvex epidural
                                                     hematoma secondary
                                                     to a skull fracture (large
                                                     red arrow)




Used with permission University of Virginia Health Sciences Center
   Red arrows denote
                                                          blood within the sulci
                                                          of the right cerebral
                                                          convexity




Used with permission University of Virginia Health Sciences Center
   The large red arrow
                                                     points to blood within
                                                     the ventricle while the
                                                     smaller red arrows
                                                     point to blood in the
                                                     sulci (subarachnoid
                                                     hemorrhage)



Used with permission University of Virginia Health Sciences Center
   Linear skull fracture
    (parietal location)
    found on bone
    windows image
Frontal   Parietal   Occipital   Temporal
 The cortical areas of the
  brain devoted to motor
  (frontal motor strip) and
  sensory (parietal sensory
  strip) function can be
  represented as an “upside”
  down person.
 A disruption in cerebral
  blood flow to these areas
  will result in a
  corresponding sensory
  and/or motor deficit to the
  corresponding region.
Artery   Lobes Supplied     Deficit

ACA      Frontal            Leg weakness

MCA      Frontal            Speech
         Lateral Temporal   Motor and sensory
         Lateral Parietal   to hand and arm

PCA      Temporal           Visual defects
                            Occipital
Normal MRI
Patient MRI
N806 and ct head

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N806 and ct head

  • 1. CT radiology  CT anatomy  Glossary of terms  Clinical indications  Systematic interpretation  Head trauma  Stroke  Tumor
  • 2.
  • 3. Brain mets/tumor  Infection/abscess  Nodes/masses  Pulmonary embolism  Abdomen/pelvis
  • 4. Patient A Patient B
  • 5. Note how the subdural bleed (left side) has compressed the ipsilateral ventricle resulting in a compensetory expansion of the contralateral ventricle. Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
  • 6. Terms beginning with A – M  Terms beginning with N - Z
  • 7. Amnesia  Cistern(s)  Corpus callosum  Arachnoid granulations  Dorsum Sellae  Arachnoid membrane  Dura mater  Basal ganglia  Falx cerebri  Basilar Artery  Globus pallidus (see basal ganglia)  Calvarium  Gyrus  Caudate (see basal  Herniation ganglia)  Insula/insullar ribbon  Internal capsule  Cerebellum  Lentiform nuclei (see basal  Cerebral cortex ganglia)  Choroid plexus  Medulla  Midbrain  Circle of Willis
  • 8.  Process where by increased intracranial pressure forces brain parenchyma through a fixed opening.  Clinical scenarios:  Transtentorial herniation (aka “uncal” herniation) ▪ Medial temporal lobes (uncus) and brainstem are forced through the tentorium ▪ Symptoms include headache, decreased consciousness, pupillary dilation and may progress to extensor posturing and death  Cerebellar herniation (rare) ▪ Cerebellar tonsils are “pushed” into the foramen magnum ▪ Similar symptoms as transtentorial herniation
  • 9.  The cerebrum is the largest part of the brain and is responsible for thought and abstraction.  The cerebrum is divided in four “lobes”. Some authors include the insula as the fifth “lobe” of the cerebrum  The outer layer of the cerebrum (cortex) is gray matter (lacks myelin)
  • 10. Anterograde amnesia = Loss of memory for an event or events immediately following a head injury.  Retrograde amnesia = Loss of memory for an event or events preceeding a head injury.
  • 11. From the Greek Arachnoid granulations arakhnoeid’s, (cobweblike)  Villous projects of the pia-arachnoid membrane whose function is to absorb CSF and return it to the venous circulation via the superior saggital sinus.
  • 12.  A thin membrane adherent to the dura mater.  The arachnoid membrane is the middle layer of the three meningial layers (dura mater, arachnoid membrane, and pia mater) that surround the brain and spinal cord.
  • 13. The basasl ganglia consists of three gray matter structures (caudate, putamen, and globus pallidus) deep within cerebral hemispheres  Lentiform nuclei = putamen and globus pallidus  Functions as motor relay stations  Pathology in the basal ganglia results in purposeless movements (Parkinson’s disease)
  • 14.
  • 15. The basilar artery provides blood to the posterior aspect of the Circle of Willis and is formed from the paired vertebral arteries. Supplies blood to the pons, cerebellum, and posterior cerebrum.
  • 16. The circle of Willis is a term used to describe the arterial supply for the brain. The circle is derived from the two internal carotid arteries as well as the basilar artery, the latter being the continuation of the two vertebral arteries.
  • 19. The bony “roof” of the skull; also know as the “skull cap”.
  • 20. The cerebellum is that portion of the brain that is involved with coordination of voluntary movement, balance, and muscle tone.
  • 21.
  • 22. Connects the brainstem with the forebrain and is involved in the control of sensory processing
  • 23. Ventricluar tissue (ependyma) that produces cerebral spinal fluid (CSF).
  • 24.  From Latin (“box”).  A well defined collection of CSF within the subarachnoid space (located between the pia and arachnoid membranes).  Several cisterns are generally described and two are of importance in the CT head:  Suprasellar - (Star-shaped) Location of the Circle of Willis  Quadrigeminal - W-shaped at top of midbrain
  • 25. The corpus callosum is the structure that connects the left and right cerebral hemispheres.
  • 26.
  • 27. The dorsum sellae is the square shaped part of the sphenoid bone that forms the posterior boundary of the pitutary fossa.
  • 29.  Latin (“hard Dura Mater Epidural hematoma Brain mother”)  The outer, fibrous portion of the meninges.
  • 30. A reflexion of the dura mater located between the cerebral hemispheres. Function is to provide support to the cerebral hemispheres.
  • 31. The rounded, elevated convolutions on the surfaces of the cerebral hemispheres.
  • 32. The insula is one of the five cerebral cortices (frontal, parietal, temporal, occipital, insular) and is located deep to the frontal, parietal, and temporal lobes. Function is to integrate autonomic functions.
  • 33. Collection of axons that carry sensory information to the cortex and motor information to the cord.  The internal capsule is very sensitive to stroke
  • 34. Aka “medulla oblongata”  Located in the brain stem and sits below the pons and in front of the cerebellum.  Functions to help control autonomic function, especially heart rate and breathing.
  • 35.
  • 36. Includes the midbrain, pons, and medulla. Major function is survival (breathing, digestion, heart rate, blood pressure) and for arousal (being awake and alert).
  • 37.  Occipital lobe  Septum pellucidum  Parenchyma  Sulcus  Parietal lobe  Suture(s)  Pineal gland  Temporal lobe  Pneumocephalus  Tentorium cerebelli  Pons  Thalamus  Posterior fossa  Uncus  Putamen (see globus  Ventricle(s) pallidus)  Sagittal sinus
  • 38. Pneumocephalus (see red arrow) is the presence of air (or gas) within the cranial cavity and is usually associated with a basilar skull fracture
  • 39.
  • 40. The sutures are fibrous connections between bones of the skull  Sutures allow for some flexibility of the cranium  Fontanelles (aka “soft spots”) are unfused areas where sutures meet  Sutures ossify at various times throughout life
  • 41. The pons sits between the brainstem and medulla  Controls rate and depth of breathing  Relays impulse from medulla to cerebrum  Clinical pathology results in:  Bilateral, fixed, pinpoint pupils (comatose patient)  Cheyne-Stokes breathing ▪ Hyperventialtion followed by apnea
  • 42.
  • 43. The uncus is the medial (innermost) portion of the temporal lobe  Under high intracranial pressure (ICP) the uncus can be involved in a transtentorial herniation syndrome  ICP pushes the uncus through the tentorium cerebelli which results in compression of the brainstem
  • 44. 1. The brain squeezes under the falx cerebri in cingulate herniation 2. The brainstem herniates caudally 3. The uncus and the hippocampal gyrus herniate into the tentorial notch 4. The cerebellar tonsils herniate through the foramen magnum in tonsillar herniation
  • 45.
  • 46. The ventricles are CSF-containing cavities  Provides a protective cushion (buoys the brain)  CSF produced in roof of ventricles (choroid plexes)  Circulation of CSF through ventricles and around the brain (subarachnoid space) and cord (central canal) with reabsorption in arachnoid villi
  • 47.
  • 48. The thalamus is the central relay station for sensory fibers (except olfactory)  Cerebral cortex communicates with thalamus  Responsible for primitive emotional responses  Fear  Pleasant vs. unpleasant stimuli
  • 49.
  • 50.  The temporal lobes are one of the five cortical lobes  The temporal lobes are responsible for hearing, speech, and some emotional and memory functions
  • 51. Lain – “groove” or “trench”  Pleural – “sulci” (sul-sigh)  The small cracks or dimples on the surface of the brain
  • 52. The septum pellucidum is a thin midline structural membrane  The septum runs vertically between the lateral ventricles as well as inferiorly from the corpus callosum
  • 53.
  • 54.  Aka “superior sagittal sinus”  Large collection of venous blood above and behind the brain  Attached to the falx cerebri  Receives CSF from the arachnoid granulations
  • 55.
  • 56.  The posterior fossa is an area within the intracranial cavity bound by the tentorium cerebelli above and foramen magnum below  The posterior fossa contains the cerebellum and brainstem structures
  • 57. Aka “pineal body”  The pineal glad is an endocrine gland that produces melatonin and is important in sleep-wake cycles
  • 58.
  • 59.  The parietal lobe is the cortical lobe responsible for sensation (cutaneous and muscular)  Responsible for integration of thoughts and feelings
  • 60.
  • 61. The functional tissue(s) (key elements) of an organ
  • 62.  The occipital lobe is the cortical lobe responsible for vision  Integration areas for visual images with sensory experiences.  Dura matter (tentorium cerebelli) separates the occipital lobe from the cerebellum
  • 63. The putamen is part of the basasl ganglia  The basals ganglia consists of three gray matter structures (caudate, putamen, and globus pallidus) deep within cerebral hemispheres  Lentiform nuclei = putamen and globus pallidus  Functions as motor relay stations  Pathology in the basal ganglia results in purposeless movements (Parkinson’s disease)
  • 64.
  • 65.  CT head is currently the procedure of choice for evaluation of suspected stroke  Stokes are either hemorrhagic (minority) or nonhemorrhagic (vast majority of cases)  Nonhemorrhagic strokes = “ischemic” strokes  The latter, if diagnosed quickly, can (potentially) be treated with thrombolytic agents  The CT can reliably serve to rule out intracranial hemorrhage  The CT is examined for evidence of vascular occlusion (clots), edema, and hemorrhage
  • 66. General considerations  Stroke anatomy  Hemorrhagic CVA  Nonhemorrhagic (ischemic) CVA
  • 67. Cerebral vascular supply (Circle of Willis)  The motor and sensory Homunculus  Arterial supply and brain function
  • 68. General considerations  CT findings
  • 69. General considerations  CT scan of hemorrhagic CVAs  Basal ganglia location  Cerebellar location  Gross pathology of cortical CVA
  • 71. Hemorrhagic strokes are due to rupture of a cerebral blood vessel  Bleeding can occur into or around the brain  Blood may extend into the ventricular system  Hemorrhagic strokes account for 16% of all strokes  Hypertensive hemorrhage accounts for approximately 70-90% of non-traumatic primary intracerebral hemorrhages
  • 72.  Etiologies include thrombus, embolism, or hypoperfusion  Ischemic brain tissue becomes edematous  Edematous tissue will appear hypodense on noncontrast CT  Hypodensity begins as early as 1h post-CVA ▪ Earliest sign of CVA is loss of gray-white differentiation (the "insular ribbon" sign)  Hypodensity is completely manifest by 12-24 hours post- CVA
  • 73. Obscuration of the lentiform nuclei  Hypoattenuation of the insular ribbon  Sulcal effacement and cortical hypodensity  Hyperdense vessel signs
  • 74. Lentiform nuclei = globbus palladus and putamen (parts of the basal ganglia)  Edema from ischemia produces hypodenity of basasl ganglia structures within hours of event  Red arrows denotes hypodensity of the basal ganglia structures (compare to opposite side)
  • 75.
  • 76. An occluded vessel (thrombus) may appear ”dark” on CT  The red arrow denotes a dense basilar artery
  • 77.  Red arrows point to hypodensity and sulcal effacement.  Note the generalized edematous appearance of the tissues within the middle cerebral artery distribution
  • 78.  Moderate - severe head trauma is an indication for a CT head scan  Some controversy exists as to when a CT should be obtained for a “minor” head injury in adults:  Canadian CT recommendations  New Orleans Criteria  For infants and children:  Considerations  General recommendations
  • 79. Things to Think About  Interpretation Mnemonics  Order of Evaluation (basic)  Bone windows  Blood (intracranial hemorrhage)  Brain parenchyma  Ventricles  Cisterns
  • 80. Introduction  CT considerations and clinical importance  Diagrams  Ventricular anatomy  CSF circulation  CT images  Normal lateral ventricles  Normal third ventricle  Ventriculomegaly  Ventricular compression and enlargement
  • 81. Brain parenchyma = brain “tissue”  The brain parenchyma is symmetrical  Gray and white matter should be well defined  Edema results in poor delineation  Midline structures (falx cerebri, third and fourth ventricles) should not be deviated  Deviated midline structures is evidence of mass effect = edema, bleeding, tumor  Check the parenchyma for evidence of blood
  • 82. General considerations  CT images  Normal midline structures  Midline shift  Cerebral edema
  • 83. Notice the sharp difference between the large hypodense edematous (red arrows) tissue and the remaining “normal” cortical tissue
  • 84. Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
  • 85. Noncontrast study is standard  A contrast study will be so designated on the CT images  Most scanners are now “ultrafast” and can perform a head CT in less than one minute  Scan spans from the base of the occiput to the top of the vertex in 5-mm increments  Three sets of data are derived from the primary scan:  Bone windows (fractures)  Tissue windows (gray/white matter density)  Subdural windows (brain bleed)
  • 86.  Evaluation of head trauma ▪ Cerebral hemorrhages ▪ Skull fracture  Suspected cerebrovascular accident (CVA)  Suspected brain tumor  Hydrocephalus
  • 87. Clinical syndromes  CT indications versus MRI
  • 88. Progressive headaches associated with:  Vomiting (especially early AM)  Behavior changes
  • 89. CT MRI  Fast, easy, available, and  Slower and more expensive relatively cheap  Soft tissue and joints  Study of choice for  Spine and spinal cord  Posterior fossa and orbits suspected brain bleed  Better for CNS  Generally good for solid developmental organs and bleeds applications  Good study for chest,  Can’t be used with certain abdomen, and pelvis pacemakers and (metal) pathology implants  Radiation exposure
  • 90. Relative Density (Attenuation)  Radiation Exposure  CT protocols  Noncontrast (“standard”)  With contrast (“enhanced”)
  • 91. IV contrast – general considerations  Clinical indications  Contraindications
  • 92. I.V. contrast is given to differentiate blood vessels from soft tissue and organs  Blood and falx appear white with contrast  Original ionic contrast agents have largely been replaced with nonionic agents (fewer reactions)  Iodine reactions were actually responses to the carrier molecule of the contrast rather than iodine  Risk related to IV contrast:  Anaphylaxis ~ 1:10,000  Death ~ 1:40,000 – 100,000  NPO X 4 hours before administration of IV contrast  Depends on urgency of exam
  • 93. Quick  Easy  Available  Inexpensive (fairly)  Standard of care for closed head injury evaluation  Shows bony calvarium well ▪ Bone windows can show fractures easily
  • 94. “The five B’s” “Blood Can Be Very Bad”  Blood  Blood = blood  Brain  Can = cisterns  Bone  Be = brain  Balloons (ventricles)  Very = ventricles  Boxes (cisterns)  Bad = bone
  • 95. Just like a standard X-ray, the CT shows dense objects (bone) as white and less dense objects (air) as black.  The concept of relative density is known as attenuation and is measured in Hounsfield Units (HU)
  • 96. Structure Hounsfield Units  Bone + 1,000  Blood + 50-100  Gray matter + 32 - 46  White matter + 22 - 36  CSF + 4 - 10  Water 0  Air -1,000 Clincal caveat: The radioglogist can place the computer cursor on any part of the CT image and determine the exact HU density – a real time way to differentiate blood from abscess from CSF, etc.
  • 97. The CT scan is a sophisticated x-ray that literally takes a continuous x-ray as it moves around the patient (tomogram)  The X-ray source and detector unit are situated opposite of each other  360 degree movement around the patient  Very thin x-ray beams are utilized  The CT computer integrates the assembled x- ray information and produces a “relative density” map that we view as a gray-scale image.
  • 98. Type of Exposure Dosage (mSv)  Background radiation 3 mSv/year  CXR 0.1 mSv  CT head 2 mSv  CT chest 8 mSv  CT abdomen and pelvis 20mSv Caveat: A CT head is the equivalent of 20 CXRs, while a CT abdomen & pelvis equals 200 CXRs! Yikes!
  • 99. General considerations  CT Description  CT images  Normal supracellar cistern  Normal quadrigeminal cistern  Compression of supracellar cistern (early)
  • 100. Notice how the right uncus is pushing into the supracellar cistern. Dx: Early uncal herniation from increased intracranial pressure
  • 101. From Latin (“box”)  Collections of CSF within the subarachnoid space (between the pia and arachnoid membranes)  Cistern pathology is usually seen on CT as compression or presence of blood  Compression ▪ Increased intracranial pressure (herniation symndrome) ▪ Mass effect (tumor)
  • 102. Several cisterns are described but two are of importance in the CT head:  Supracellar cistern ▪ Star-shaped (“super star”) ▪ Location = Circle of Willis  Quadrigeminal cistern ▪ W-shaped (looks like a baby’s bottom) ▪ Location = Level of tentorium cerebelli
  • 103. A. Falx Cerebri B. Frontal Lobe C. Anterior Horn of Lateral Ventricle D. Third Ventricle E. Quadrigemina Cistern F. Cerebellum Can you visualize the “baby’s bottom”?
  • 104. Notice how the falx is deviated (white arrow) due to a space filling lesion (red outline)
  • 105. Developed from a series of patients ( > 16 years-of-age) presenting with minor head injury (defined as GCS score of 13-15 after loss of consciousness, definite amnesia, or witnessed disorientation from trauma)  Clinical criteria consist of five high-risk and two moderate-risk factors.
  • 106. Obtain CT Head if patient has > one the following seven:  GCS score lower than 15 two hours after injury  Suspected open or depressed skull fracture  Any sign of basal skull fracture  Two or more episodes of vomiting  Age 65 years or older  Retrograde amnesia > 30 minutes  Dangerous mechanism  Motor vehicle involved  Fall from a height of at least three ft or five stairs
  • 107.
  • 108.
  • 109. CT is needed if the patient > one of the following:  Headache  Vomiting  Age older than 60 years  Drug or alcohol intoxication  Persistent anterograde amnesia (deficits in short-term memory)  Visible trauma above the clavicle  Seizure *Applicable for adults with a normal Glasgow Coma Scale score of 15 and blunt head trauma that occurred within the previous 24 hours that caused loss of consciousness, definite amnesia, or witnessed disorientation.
  • 110. Evaluate the significance of the injury by physical findings AND mechanism of injury  Kids have heavy heads and weak necks  Younger children are less likely to be symptomatic  Signs of significant head injury can be subtle (persistent irritability)  Scalp hematomas in infants and toddlers suggest significant injury
  • 111. All moderate and severe head trauma  Any loss of consciousness  Age under 3 months  Skull fracture (intracranial injury in 15-30%)  Scalp hematoma predicts fracture (>80% sensitivity)  Depressed mental status  Focal neurologic deficits  Bulging fontanelle  Persistent irritability after head injury  Seizure following head injury  Recurrent vomiting after injury
  • 112.
  • 113. Bone windows for fractures  Brain tissue  Hemorrhage or masses  Symmetry  Midline shift  Edema  Ventricles  Compression, blood, or hydrocephalus  Subarachnoid cistern compression
  • 114. The head contains four things (skull, brain, blood, spinal fluid)  The CT is reviewed to make sure all four are in the right amount and location  The brain is symmetrical; asymmetry is abnormal  The cerebral hemispheres are mirror image structures - what is on the left should be on the right
  • 115. Prior contrast reaction (“iodine allergy”)  Poor renal function  Creatinine > 2.0  Lack of consent  Suspend breast feedings for 24 hours following I.V. contrast Shellfish and/or Betadyne allergies are not contraindications
  • 116. A. Orbit B. Sphenoid Sinus C. Temporal Lobe D. External Auditory Canal A. Orbit E. E. Mastoid Air Cells Mastoid Air Cells B. Sphenoid Sinus F. F. Cerebellar Hemisphere Cerebellar Hemisphere C. Temporal Lobe D. External Auditory Canal Used with permission University of Virginia Health Sciences Center
  • 117. A. Frontal Lobe B. Frontal Bone (Superior Surface of Orbit) C. Dorsum Sellae D. Basilar Artery E. Temporal Lobe F. Mastoid Air Cells G. Cerebellar Hemisphere
  • 118. A. Frontal Lobe B. Sylvian Fissure C. Temporal Lobe D. Suprasellar Cistern E. Midbrain F. Fourth Ventricle G. Cerebellar Hemisphere Used with permission University of Virginia Health Sciences Center
  • 119. A. Frontal Lobe B. Falx Cerebri C. Anterior Horn of Lateral Ventricle D. Third Ventricle E. Quadrigeminal Plate Cistern F. Cerebellum Used with permission University of Virginia Health Sciences Center
  • 120. A. Anterior Horn of the Lateral Ventricle B. Caudate Nucleus C. Anterior Limb of the Internal Capsule D. Putamen and Globus Pallidus E. Posterior Limb of the Internal Capsule F. Third Ventricle G. Quadrigeminal Plate Cistern H. Cerebellar Vermis I. Occipital Lobe Used with permission University of Virginia Health Sciences Center
  • 121. A. Genu of the Corpus Callosum B. Anterior Horn of the Lateral Ventricle C. Internal Capsule D. Thalamus E. Pineal Gland F. Choroid Plexus G. Straight Sinus Used with permission University of Virginia Health Sciences Center
  • 122. A. Falx Cerebri B. Frontal Lobe C. Body of the Lateral Ventricle D. Splenium of the Corpus Callosum E. Parietal Lobe F. Occipital Lobe G. Superior Sagittal Sinus Used with permission University of Virginia Health Sciences Center
  • 123. A. Falx Cerebri B. Sulcus C. Gyrus D. Superior Sagittal Sinus Used with permission University of Virginia Health Sciences Center
  • 124. Supracellar cisterrn (can you visualize the “star” shape) Fourth Ventricle F = frontal lobes U = uncus (medial temporal lobes) Po = Pons
  • 125. Dura (retracted) Bridging vein(s)
  • 127. 1 - Anterior Fossa 2- Posterior Fossa 3- Frontal Sinus 4- Esphenoid Sinus 5- Tentorium Cerebelli
  • 128. Majority are due to aneurysms or arterioventricular malformations (AVM)  Bleeding is into the CSF space  Ability to diagnose with CT decreases with time: ▪ 95% positive at 12 hours ▪ 80% positive at 3 days ▪ 30% positive at two weeks
  • 130. Below the dura but above the arachnoid  Usually venous in origin  Commonly a ruptured bridging vein (dural drainage)  Cresent or sickle shaped pattern on CT  Can cross suture lines  Common in elderly or anti-coagulated  Density of blood determines the age of the bleed:  Acute  Chronic
  • 131. aka “intracerebral” hemorrhage  Can follow hypertensive stroke  Can follow deceleration (“contusion”) injuries  Can extend into the ventricles (intracerebral extension)
  • 132. Hemorrhage into the ventricular system  Can be an extension of an intraparenchymal or subarachnoid bleed  Can be secondary to trauma (poor outcome)  Not uncommon in extremely premature infants  Obstructive hydrocephalus can be a complication
  • 133. Arterial blood  Usually secondary to a linear skull fracture through an arterial channel (like the middle meningeal artery)  Biconvex shape (lens shaped)  Bleeding may cross the midline  Bleeding won’t cross suture lines  A subdural and an epidural may occur together  Epi vs. sub doesn’t matter – but volume does  > 5 mm or > 10 mm in adults = surgical evacuation
  • 134. Early ICP Findings Late ICP Findings  Headache  Cushings triad  Vomiting  Hypertension  Vision distortion  Bradycardia  Decreased sensorium  Papilledema possible  Flexor/extensor posturing  Pupillary dysfunction
  • 135. Haydel MJ, Preston CA, Mills TJ, Luber S, Blaudeau E, DeBlieux PM. Indications for computed tomography in patients with minor head injury. N Engl J Med. 2000;343:100-5.  Stiell IG, et al. Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury. JAMA. 2005;294:1511-8.  www.aafp.org/online/en/home/clinical/clinica lrecs/headinjurychild.html
  • 136. Basic properties  Skull fractures  Suture lines versus fracture lines  Basilar skull fracture  Child abuse and skull fractures
  • 137.  Fracture in any location other than parietal location  Non-linear fracture  Linear fracture length exceeding 6 cm  Fracture crossing suture lines
  • 138.
  • 139.  The bone windows information is part of the routine CT head and is ideal for viewing fractures  Sinuses can be seen well with bone windows  The scout film of the CT scan is roughly the equivalent of a lateral skull x-ray film – so look at it too  Remember to look at the overlying soft tissue for swelling as it may point to an underlying skull fracture
  • 140. Skull fractures may be classified as either linear or comminuted  Inwardly displaced comminuted = depressed skull fx ▪ A depressed skull fracture requires immediate neurosurgical evaluation  Cranial sutures can be confused with linear fractures
  • 141. Suture Fracture  Characteristic locations Usually temperoparietal  Symmetrical line on other side Asymmetrical  Same size throughout Widest at the center/ narrow at the end  Graceful curvy lines Straight lines with angular turns
  • 142. A fracture of the orbital roof, sphenoid bone, or mastoid portion of temporal bone  Usually resolve on their own but can be:  Displaced  Cranial nerve damage (II, VII, VIII)  CSF leak (otorhea or rhinorhea)  “Classic” clinical findings may (or may not) be present
  • 143. Hemotympanum  Periorbital bruising ("raccoon eyes“)  Cerebrospinal fluid otorrhea or rhinorrhea  Battle's sign (Mastoid eccymoses)  Pneumocephalus  (Air and fluid/levels in sinuses)
  • 144. Superior to inferior  Falx cerebri  Body of lateral ventricles  Internal capsule and thalamus  Caudate and third ventricle  3rd Ventricle and quadrigeminal cistern  Supracellar cistern and 4th ventricle
  • 145. Extra-axial hemorrhage Intra-axial hemorrhage (outside the brain) (inside the brain)  Subarachnoid (SAH)  Epidural  Below the arachnoid membrane  Below the skull  On the surface of the brain  “above” the dura  Intraparenchymal (IPH)  Subdural  Within the substance of the  Below the dura brain  Above the thin, spidery-like  Intraventricular (IVH) arachnoid membrane  Within the ventricles
  • 146. CSF-filled balloons  CSF Direction of Flow:  CSF is produced in the  Lateral ventricles choroid plexes,  Foramen of Monroe “circulates” through  Third ventricle the ventricular system,  Cerebral aqueduct percolates over the  Fourth ventricle surface of the cord and  Foramen (Magendie and brain, and is absorbed Lushka) in the arachnoid  Subarachnoid space granulations  Arachnoid granulations  Venous circulation
  • 147. Size  Large = too much fluid or brain atrophy  Small = Compression (edema or mass)  Symmetry  Asymmetry = impingement from mass/edema, etc.  Presence of blood  IVH can lead to secondary hydrocephalus  Anatomic landmarks  Lateral and 3rd ventricle are supratentorial ▪ 3rd is located anterior to the pineal gland ▪ Looks like an exclamation point  4th ventricle is infratentorial ▪ Looks like a pith helmet (roundish)
  • 148. Considerations  Ventricular system  CSF circulation  CT images:  Hydrocephalus  Asymmetry (impingement from tumor)  IVH
  • 149. A tough, fibrous structure separating the cerebrum above and the cerebellum and brain stem below  Provides support for the cerebrum  Structures above the tentorium are known as supratentorial or anterior fossa  Structures below the tentorium are known as infratentorial or posterior fossa
  • 150. 1 - Anterior Fossa 2- Posterior Fossa 3- Frontal Sinus 4- Esphenoid Sinus 5- Tentorium Cerebelli
  • 151. Frontal Parietal Occipital Temporal
  • 152.
  • 153. Note collection of blood above the dura mater Dura mater
  • 155.
  • 156.
  • 157. Majority can be visualized without contrast  Contrast is indicated if brain tumor is suspected and not see on noncontrast study  Appear as edematous, low density, poorly- defined lesions  Classified as intraaxial (within the brain tissue) or extraaxial  Adult tumors are usually supratentorial while pediatric tumors are usually infratentorial  Many metastatic tumors will be located at the gray-white matter border(s)
  • 158. General considerations  Brain tumors  Meningioma  Astrocytoma (pediatric)
  • 159.  Cystic mass in the midline of the cerebellum (red arrows)  Note early hydrocephalic changes secondary to tumor compression (yellow arrows)
  • 160. Red arrow points to a large cerebellar hemorrhage Used with permission University of Virginia Health Sciences Center
  • 161. Cocaine induced hypertensive CVA  Note the large hemorrhagic lesion in the left cortical area as well as multiple smaller regions (redness) near the hippocampus and other cortical regions. www.utsa.edu/tsi/assign/anat/neuropat.htm
  • 162.  Loss of the gray- white interface in the lateral margins of the insula  The cortex of the left insular ribbon is not visualized (arrow).  Right insular ribbon is outlined in yellow
  • 163. Contrast enhanced CT of meningioma (most common extraxial brain tumor)
  • 164. Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
  • 165. A. Falx Cerebri B. Frontal Lobe C. Body of the Lateral Ventricle D. Splenium of the Corpus Callosum E. Parietal Lobe F. Occipital Lobe G. Superior Sagittal Sinus Used with permission University of Virginia Health Sciences Center
  • 166. Edema  The darker gray Edema areas represent Blood Blood edema while the white areas represent the intracerebral contrusion (“bruise”) Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
  • 167. Used with permission by the CRASH Trials with credit to Mr. J. Wasserberg and Mr. B. Mitchell
  • 168. Small red arrows point to a biconvex epidural hematoma secondary to a skull fracture (large red arrow) Used with permission University of Virginia Health Sciences Center
  • 169. Red arrows denote blood within the sulci of the right cerebral convexity Used with permission University of Virginia Health Sciences Center
  • 170. The large red arrow points to blood within the ventricle while the smaller red arrows point to blood in the sulci (subarachnoid hemorrhage) Used with permission University of Virginia Health Sciences Center
  • 171. Linear skull fracture (parietal location) found on bone windows image
  • 172. Frontal Parietal Occipital Temporal
  • 173.  The cortical areas of the brain devoted to motor (frontal motor strip) and sensory (parietal sensory strip) function can be represented as an “upside” down person.  A disruption in cerebral blood flow to these areas will result in a corresponding sensory and/or motor deficit to the corresponding region.
  • 174. Artery Lobes Supplied Deficit ACA Frontal Leg weakness MCA Frontal Speech Lateral Temporal Motor and sensory Lateral Parietal to hand and arm PCA Temporal Visual defects Occipital