5. Zanamivir is used in
the treatment of the
infection caused by
the flu virus (influenza
A and influenza B).
This medicine may
also be used to
prevent
and
treat
swine influenza A.
7. Zanamivir may not
be for you if you are
severely sick or
have a breathing
problem
(e.g.,
asthma or chronic
obstructive
pulmonary disease).
8.
9. Usual Adult Dose for
Influenza
•10 mg (2 inhalations)
inhaled orally twice a day
(12 hours apart) for 5
days
10. Usual Adult Dose for
Influenza Prophylaxis
•10 mg (2 inhalations)
inhaled orally once a day
11.
12. The
proposed
mechanism of action of
zanamivir
is
via
inhibition of influenza
virus
neuraminidase
with the possibility of
alteration
of
virus
particle aggregation and
release.
16. Influenza A Virus
•causes influenza in
birds
and
some mammals
•cause severe disease
both in domestic poultry
and, rarely, in humans
•transmitted from wild
aquatic
birds
to
domestic poultry
20. ROCKVILLE, Md., June
23, 2010--The FDA has
posted on its web site
letters that announce
the
termination
of
declarations for
the
emergency
use
antiviral
drugs
Zanamivir, Oseltamivir
Phosphate, etc
25. Famvir (famciclovir) is
an antiviral drug that
slows the growth and
spread of the herpes
virus so that the body
can
fight
off
the
infection.
26. Famvir is used to treat
infections caused by
herpes
viruses,
including
genital
herpes, cold sores, and
shingles.
27. FAMVIR for Cold Sores
are white, oval, filmcoated tablets with "FV
500" on one side.
Each carton contains 3
tablets in a blister pack
with 'FAMVIR famciclovir
500mg printed on the
foil backing
28.
29. Tablets: 125, 250, and
500
mg
storage:
famciclovir should be
stored
at
room
temperature, 15-30 C
(59-86 F).
30. DOSING: may be taken
with or without food.
The
recommended
doses are:
•Recurrent
genital
herpes: 1,000 mg every
12 hours for one day.
•Recurrent cold sores:
1,500 mg as a single
dose
34. In cells infected with HSV1, HSV-2 or VZV, viral
thymidine
kinase
phosphorylates
penciclovir
to
a
monophosphate
form
that, in turn, is converted
to
penciclovir
triphosphate by cellular
kinases
36. Penciclovir triphosphate
has an intracellular halflife of 10 hours in HSV-1-,
20 hours in HSV-2-and 7
hours in VZV-infected cells
grown
in
culture.
However,
the
clinical
significance
of
the
intracellular half-life is
unknown.
37.
38.
39. Herpes simplex virus 1
(HSV-1)
-oral sores
•causes sores around the
mouth and lips
•sometimes called fever
blisters or cold sores.
40. Herpes simplex virus 2
(HSV-2)
•genital sores
•sores
around
the
genitals or rectum
•Although HSV-2 sores
may occur in other
locations, these sores
usually are found below
the waist.
45. •causes chickenpox and
herpes zoster (shingles).
•Chickenpox
follows
initial exposure to the
virus and is typically
relatively mild, and selflimiting
with
a
characteristic exanthem,
but
can
become
disseminated.