8 million women and 2 million men in the US are diagnosed with osteoporosis. The document discusses the history of defining and diagnosing osteoporosis and osteopenia, and how drug companies worked to expand the definition of osteopenia to increase the market for osteoporosis drugs like Fosamax. Long term use of Fosamax has been linked to spontaneous bone fractures through impaired bone healing. Lifestyle factors like exercise, diet, and vitamin D can help promote strong bones.
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osteoporosis
1. 8 million women in the United States are
currently diagnosed with osteoporosis
2 million men suffer from the disease
Healthy Bones Healthy Life
Osteoporosis Cause and Solution
6. BONES
Osteo Blasts (Build)
Osteo Clasts
(remove old bone)
Produce RBC
Support body
Balance flexibility
With Strength
7. OSTEOPOROSIS VS OSTEOPENIA
Osteoporosis 1992 Rome Italy meeting for definition
of osteoporosis World Health Organization
how to diagnose and measure osteoporosis
Doctors and researchers didn't even have a shared
view of how osteoporosis should be defined.
After 30 years old bone loss is normal so what is
normal what is pathological
On a gage they just drew a line on the graph
Osteopenia was invented for researchers to use
never was intended for a disease category
Osteopenia natural thinning of the bone
8. DRUG COMPANIES PRODUCE INCREDIBLE
DRUGS THAT CAN GREATLY RELIEVE SUFFERING
one way they profit from those drugs is to extend
their use to as many people as possible,
I.D. milder and milder versions of a disease
Osteoporosis and Osteopenia
Diabetes type 2
Depression
High cholesterol
High Blood Pressure
pharmaceutical firms stand to benefit if the
therapies for these diseases are broadly used
Caleb Alexander, a pharmaco-epidemiologist at the
University of Chicago
9. BONE MEASUREMENT INSTITUTE
1995 Merck Fosamax 1st non hormonal treatment (hormonal
treatments caused Cancer)
To increase sales had to get women to get a bone densitometer
check $300 per test and only 200 machines in USA (expensive
and inaccessible)
Created and institution “Bone measurement institute” Non
profit established by Merck
headed by Jeremy Allen = no building only the non profit
institute was his desk at Merck
10. BONE MEASUREMENT INSTITUTE
Merck Found cheep small measurements wrist, forearm, heals
periphery scanners
Peripheral machine are not accurate Dr. Sanford Bane pres
international society for clinical Densitometry
Merck bought a company to measure peripheral made
machines at a very low price (then dissolved the company)
Merck funded FDA studies for the smaller machines
Merck got Medicare to pay for (bone mass medication act)
1997
1997 Merck got clearance from the FDA for a new version
of its drug.
"Merck developed a dose of Fosamax, a 5-milligram — a
lower dose that was intended for use by women with
osteopenia,“
11. A DIAGNOSIS WAS BORN.
Medicare claims for scans 77,000 in
1994
More than 1.5 million annually by 1999
the sale of peripheral machines went up
more than 500 percent over the same
period of time.
Thru testing and advertising a cultural
consensus took hold
Osteopenia became a condition that was
seriously considered for treatment
2010
34 million have Osteopenia
12. Fosamax
The long-term use of osteoporosis drugs known as
bisphosphonates can actually weaken bones by
impairing their ability to heal, leading to fractures,
according to a study ….from New York-
Presbyterian Hospital/Weill Cornell Medical
Center
From RXLIST.COM
The efficacy of FOSAMAX has been established in
studies of two years' duration.
The greatest increase in bone mineral density occurred in
the first year with maintenance or smaller gains during
the second year.
Efficacy of FOSAMAX beyond two years has not
been studied.
13. "MY LEG JUST SNAPPED"
"low impact" or "no impact" fractures occurring in women taking
Fosamax long term
• feeling the bone break before they hit the floor.
• “I slipped and fell, but I really felt the bone snap before I went
down It was like the bone broke and that is actually what
caused me to fall.“
• A woman who was wading in water who was struck at thigh
level by the wake of a small boat, causing the bone to snap.
14. Studies link Fosamax to spontaneous bone fractures.
If you have experienced broken bones while taking Fosamax, you may be
eligible for compensation through a Fosamax lawsuit.
Fosamax® is a drug designed to strengthen bones. However, studies indicate that
it could cause them to break instead.
Recent findings show that some Fosamax users have suffered from broken bones,
including the femur bone, the hardest bone in the body.
Researchers have found that women taking Fosamax over extended periods of
time are 125 times more likely to suffer a femur fracture from falls than women not
taking the drug.
Industry insiders allege that these potential side effects have been known for years.
In 2008, the FDA contacted Fosamax manufacturer, Merck, about continuous
reports linking Fosamax to femur fractures. Sadly, it took 16 months for Merck to
add femur fractures to the list of potential side effects included on the drug package
insert.
In addition to spontaneous, low trauma-induced femur fractures, Fosamax side
effects can also include osteomyelitis, or inflammation of bone marrow, and
osteonecrosis of the jaw (ONJ), also known as dead jaw disease.
On October 13, 2010, the FDA issued an alert to doctors about the possibility of
severe bone pain related to bisphosphonate drugs such as Fosamax. Despite
hundreds of Fosamax lawsuits, studies and FDA warnings, Merck continues to sell
Fosamax
15. older than 65 in America
broken a bone after age 50
health is “fair” or “poor”
Smoke
underweight for my height
started menopause before age 45
have more than two drinks of alcohol several
times a week
sometimes fall
not physically active
· Medical conditions:
· Hyperthyroidism
· Chronic lung disease
· Cancer
· Inflammatory bowel disease
· Chronic hepatic or renal disease
· Vitamin D deficiency
· Cushing’s disease
· Multiple sclerosis
· Rheumatoid arthritis
·medications:
· Oral glucocorticoids (steroids)
· Cancer treatments (radiation,
chemotherapy)
· Thyroid medicine
· Antiepileptic medications
· Gonadal hormone suppression
·Immunosuppressive agents
Anti-acids, antidepressents, HTN,
Risk factors for poor bone health
16. Metabolism
Anabolism = Constructive metabolism
Re-growth Repair
Catabolism = Metabolic Breakdown , For energy burning
aspect dismantling of structural proteins
(starvation/Fat utilization)
R>B=Health
R<B=Disease
17. Infections contracted in
hospitals are the fourth
largest killer in the United
States
causing as many deaths
as AIDS, breast cancer
and auto accidents
combined.
— One out of every 20
hospital patients gets an
infection.
103,000 of die each year
20. ASK YOUR DOCTOR IF THIS IS RIGHT FOR YOU
"We can't solve problems by using the same kind of thinking we used
when we created them."
Albert Einstein
21.
22. DIS-EASES OF “D” DEFICIENCIES
Diabetes
Vitamin D deficiency has been associated with insulin deficiency and insulin
resistance.
Heart Disease
Insulin resistance is also one of the major factors not only leading to the cancers
mentioned above, but also to the number one killer in the US, heart disease.
Northern countries have higher levels of heart disease and more heart attacks occur
in the winter months.
Arthritis
Progression of degenerative arthritis of the knee and hip is faster in people with
lower vitamin D concentrations
Infertility and PMS
Infertility is associated with low vitamin D and PMS has been completely reversed by
addition of calcium, magnesium and vitamin D.
TB =solariums
Osteoporosis
23. “D” DOSAGE
Make sure supplements are Vit D 3000 IU
per 100 lb of body weight
if you have a disease 5000IU
per 100lb body weight
Skin can make 20,000 IU per day
Vit D 3 100,000 IU per day for 2 days if there is an
acute infection
25. 4 Keys to Strong Bones
1.Regular exercise key to maintaining strong bones
throughout our lifetime.
2.Calcium- Bones weaken when you have low levels of
vital minerals such as calcium and vitamin D. With age,
dietary calcium intake and the body's ability to absorb
calcium tend to fall.
3. Poor habits such as smoking, excess alcohol
consumption and a lack of exercise can all reduce bone
formation
4.Regain pH Balance – eat more green leafy veggies,
eliminate corporate foods
26. PHYTONUTRIENTS
1. Stop viruses adhering to cell walls
(Cranberry bladder infect)
2. Antioxidant
3. Antibacterial
4. Stimulate or suppress enzymes
5. Stop Abnormal DNA replication (Cancer)