Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Medyo final patho slide orientation


Published on

  • ⇒⇒⇒ ⇐⇐⇐ has really great writers to help you get the grades you need, they are fast and do great research. Support will always contact you if there is any confusion with the requirements of your paper so they can make sure you are getting exactly what you need.
    Are you sure you want to  Yes  No
    Your message goes here
  • Be the first to like this

Medyo final patho slide orientation

  1. 1. By: Abel, Joriz Kevin Abergas, Unica May
  2. 2.  Cause remains unknown  Factors that contribute to development, progression and chronicity :  Genetic Susceptibility ▪ HLA-DRB1: shared epitope is specific binding site of arhritogens ▪ PTPN22: activation and control of inflammatory cells  Environmental arthritogens ▪ Microbial agents ▪ Citrullinated proteins  Autoimmunity ▪ Rheumatoid factors
  3. 3. Genetic susceptibility Arthritogens Activation of CD4+ helperT cells Release of cytokines INF-γ & IL-17 Stimulation of synoviocytes and macrphages Production of pro-inflammatory molecules: IL-1, 6, 23,TNF, PGE2, NO,GF, GM-CSF,TGF-β Increase production of cartilage matrix metalloproteinases Stimulation of osteoclastogenesis and osteoclast activity Synoviocytes up- regulate vascular cell- adhesion molecule Edematous, hyperplastic, sticky synovium Pannus formation and resorption of the adjacent bone PATHOGENESIS
  4. 4.  Inflammatory infiltrate composed of lymphoid aggregates  Increased vascularity  Accumulation of neutrophils  Pannus formation
  5. 5.  Manifestations:  Mild general aching and stiffness  Inflammation may be apparent first in the wrists and fingers  Joints appear red and swollen and often very sensitive to touch as well as painful  Joint stiffness  “burned out”  Systemic signs are marked during exacerbations and inclued fatique, anorexia, mild fever, lymphadenopathy and genralized aching
  6. 6.  Complications:  Effects on the Skin ▪ Rheumatoid Nodules  Eye Complications ▪ Inflammation of the episclera ▪ Scleritis ▪ Sjogren's syndrome
  7. 7.  Effects on Heart and BloodVessels  Pericardial Effusion  Pericarditis  Myocarditis  Diseases of the Blood and Blood-Forming Cells  Anemia  Felty's syndrome
  8. 8.  Lung Problems  Emotional Effects  Susceptibility to Infection