DIC

1. WHAT ARE THE FACTORS THAT
PREVENT INTRAVASCULAR
COAGULATION? DISCUSS.
Hare Ram Karn
2009928111

2. Coagulation
Due to :
- Trauma to the blood
- Trauma to the tissue
- Contact of Blood with collagen fibers
- Damaged Endothelial cells
Soluble Fibrinogen Insoluble Fibrin
Formation Of ClotFormation Of Clot

3. FACTORS :
1 Endothelial Surface Factors
2 Speed of the blood Flow
3 Presence of Natural Anticoagulants
- Heparin
- Antithrombin-III

4. ANTICOAGULATING ROLE OF ENDOTHELIAL
CELLS
- Provide intact barrier between
blood and subendothelial
connective tissue.
- Synthesize and release PG & NO
- Secrete TPA
- Display Heparin Molecule on its own
Plasma membrane
-Bind Thrombin via thrombomodulin
receptor

5. ENDOTHELIAL SURFACE
FACTORS
 Smoothness of The Endothelium
 Presence of Monomolecular Protein
 Presence of Glycocalyx

6. THROMBOMODULIN
ANTICOAGULANT
MECHANISM
-

7. HEPARIN
-Usually present in low concentration.
-Has no or little anticoagulant properties.
-Becomes effective after combining with
Antithrombin III for the inactivation of
Thrombin,thus acts as anticoagulants.
-Heparin-Antithrombin III complex also
inactivates other activated factor IX, X, XI,
XII.

8. ANTITHROMBIN ACTION OF FIBRIN &
ANTITHROMBIN III
During the formation of clot 80-90% of thrombin is
absorbed to the fibrin fibres and spread of clot is
prevented
Remaining thrombin combines with
Antithrombin III
Leading to  Blockage of effect of
Thrombin on fibrinogen.
Inactivation of Thrombin
itself.

9. THANK
YOU

10. THANK
YOU