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TEST YOUR MEMORY (TYM): A NEW TOOL TO EVALUATE THE COGNITIVE FUNCTION 
IN CHRONIC External Chair of Pain Grünenthal 
@observadolor 
PAIN PATIENTS. 
Conclusion 
Ojeda B1, Dueñas M1, Salazar A1, Torres LM2, Micó JA3, Failde I1. 
1Preventive Medicine and Public Health Department, University of Cádiz, 2Anesthesiology-Critical Care and Pain Management, 
University Hospital, Cádiz, 3NeuroScience Department, University of Cádiz, Spain. 
Foundation-University of Cádiz. Background & Aims 
Taking into account the need for an instrument 
to assess cognitive function in chronic pain 
patients in routine clinical practice, and 
considering the good properties of the nnnneeeewwww TTTTYYYYMMMM 
WWWWhhhhaaaatttt aaaannnndddd hhhhoooowwww iiiissss tttthhhheeee TTTTYYYYMMMM 
tttteeeesssstttt???? 
Double 
sided sheet 
TTTTYYYYMMMM pppprrrrooooppppeeeerrrrttttiiiieeeessss ccccoooommmmppppaaaarrrreeeedddd ttttoooo MMMMMMMMSSSSEEEE 
CCCCPPPP ((((222255554444)))) CCCCoooonnnnttttrrrroooollllssss ((((77772222)))) NNNNPPPP ((((111100004444)))) MMMMSSSSKKKK ((((99999999)))) FFFFMMMM ((((55551111)))) 
iiiinnnnssssttttrrrruuuummmmeeeennnntttt to assess cognitive function, in 
this study wwwweeee pppprrrrooooppppoooosssseeeedddd ttttoooo aaaannnnaaaallllyyyyzzzzeeee tttthhhheeee vvvvaaaalllliiiiddddiiiittttyyyy 
aaaannnndddd rrrreeeelllliiiiaaaabbbbiiiilllliiiittttyyyy ooooffff tttthhhheeee SSSSppppaaaannnniiiisssshhhh vvvveeeerrrrssssiiiioooonnnn ooooffff tttthhhhiiiissss 
Includes different tasks to 
assess 10 cognitive domains 
Original structure (Brown, 2009) No. of 
Score 
TTTTYYYYMMMM MMMMeeeeaaaannnn ((((SSSSDDDD)))) 
IIIICCCC ((((99995555%%%%)))) 
MMMMiiiinnnniiiimmmmuuuummmm 
MMMMaaaaxxxxiiiimmmmuuuummmm 
FFFFlllloooooooorrrr ((((%%%%)))) 
44440000....5555 ((((5555....5555)))) 
33339999....8888-44441111....2222 
22221111 
55550000 
0000....4444 
44443333....9999 ((((4444....1111)))) 
44443333-44444444....9999 
33331111 
55550000 
1111....4444 
44440000....5555 ((((6666....2222)))) 
33339999....3333-44441111....7777 
22221111 
55550000 
1 
44440000....7777 ((((5555....4444)))) 
33339999....6666-44441111....8888 
22226666 
44449999 
3 
44440000....2222 ((((4444....4444)))) 
33338888....9999-44441111....44445555 
33331111 
55550000 
2 
• Test Your Memory 
is a quick and 
easy tool to 
qqqquuuueeeessssttttiiiioooonnnnnnnnaaaaiiiirrrreeee iiiinnnn ppppaaaattttiiiieeeennnnttttssss wwwwiiiitttthhhh cccchhhhrrrroooonnnniiiicccc ppppaaaaiiiinnnn 
10 
2 
3 
4 
MMMMeeeetttthhhhoooodddd 
ffffrrrroooommmm tttthhhhrrrreeeeeeee ddddiiiiffffffffeeeerrrreeeennnntttt oooorrrriiiiggggiiiinnnnssss. 
items 
1111.... OOOOrrrriiiieeeennnnttttaaaattttiiiioooonnnn 
2222.... CCCCooooppppyyyyiiiinnnngggg.... 
3333.... RRRReeeettttrrrrooooggggrrrraaaaddddeeee mmmmeeeemmmmoooorrrryyyy ((((sssseeeemmmmaaaannnnttttiiiicccc kkkknnnnoooowwwwlllleeeeddddggggeeee)))).... 
4444.... CCCCaaaallllccccuuuullllaaaattttiiiioooonnnn.... 
9 
1 
2 
4 
CCCCeeeeiiiilllliiiinnnngggg ((((%%%%)))) 
1111....2222 
5555....6666 
1111....9999 
1 
2 
MMSE Mean (SD) 
IC (95%) 
Minimum 
Maximum 
26.9 (2.2) 
26.7-27.2 
17 
30 
29.1 (1.4) 
28.8-29.4 
24 
30 
26.9 (2.2) 
26.5-27.4 
17 
30 
27 (2.3) 
26.5-27.4 
20 
30 
26.8 (2.3) 
26.2-27.5 
19 
30 
evaluate cognitive 
function. 
• TYM test shows 
Instruments 
Cognitive function:Test Your 
Subjects 
5555.... VVVVeeeerrrrbbbbaaaallll fffflllluuuueeeennnnccccyyyy.... 
6666.... SSSSiiiimmmmiiiillllaaaarrrriiiittttiiiieeeessss.... 
7777.... NNNNaaaammmmiiiinnnngggg.... 
8888.... VVVViiiissssuuuuoooossssppppaaaattttiiiiaaaallll aaaabbbbiiiilllliiiittttyyyy 1111 &&&& 2222 ((((cccclllloooocccckkkk)))).... 
9999.... AAAAnnnntttteeeerrrrooooggggrrrraaaaddddeeee mmmmeeeemmmmoooorrrryyyy. 
1 
2 
5 
2 
1 
4 
4 
5 
7 
6 
IIIInnnntttteeeerrrrnnnnaaaallll ccccoooonnnnssssiiiisssstttteeeennnnccccyyyy 
Floor (%) 
Ceiling (%) 
0.4 
9.4 
1.4 
58.3 
1 
8.7 
1 
11.1 
2 
7.8 
The higher scores represent 
better cognitive function. 
good 
psychometric 
properties in 
FFFFaaaaccccttttoooorrrr 
8 factors identified 
Memory test (TYM) and Mini Mental 
State Examination (MMSE). 
Psychiatric disorders: Hospital 
Anxiety and depression scale 
254 chronic pain (CP) 
patients (pain ≥3 
months): 
104 neuropathic (NP) 
99 Musculoskeletal 
11110000.... EEEExxxxeeeeccccuuuuttttiiiivvvveeee ((((aaaabbbbiiiilllliiiittttyyyy ttttoooo ccccoooommmmpppplllleeeetttteeee tttthhhheeee tttteeeesssstttt)))).... 
1 
5 
28 50 
Range of item correlations 
DDDDoooommmmaaaaiiiinnnnssss No. of 
items 
IIIItttteeeemmmm-iiiinnnntttteeeerrrrnnnnaaaallll 
ccccoooonnnnssssiiiisssstttteeeennnnccccyyyya 
Item-discriminant 
consistencyb 
(Cronbach’s alpha was 0.66) chronic pain 
patients. 
aaaannnnaaaallllyyyysssseeeessss: 
Eigenvalues ranging from 3,5 
to1,1. 
Percentage of total variance 
acconted for 53%. 
(HADs) 
Sleep: Medical Outcome Study 
Sleep scale (MOS-Sleep scale). 
Quality of life: SF-12 v1 
(MSK) 
52 fibromyalgia (FM) 
DDDDeeeemmmmooooggggrrrraaaapppphhhhiiiicccc aaaannnndddd cccclllliiiinnnniiiiccccaaaallll cccchhhhaaaarrrraaaacccctttteeeerrrriiiissssttttiiiiccccssss ((((CCCCPPPP ppppaaaattttiiiieeeennnnttttssss:::: nnnn==== 222255554444)))) 
72 control subjects free NNNNeeeeuuuurrrrooooppppaaaattttiiiicccc ppppaaaaiiiinnnn (NP) 
OOOOrrrriiiieeeennnnttttaaaattttiiiioooonnnn 
SSSSeeeemmmmaaaannnnttttiiiicccc kkkknnnnoooowwwwlllleeeeddddggggeeee 
CCCCaaaallllccccuuuullllaaaattttiiiioooonnnn 
SSSSiiiimmmmiiiillllaaaarrrriiiittttiiiieeeessss 
9 
2 
4 
2 
....22220000-....55550000 
....77776666-....77777777 
....55551111-....77777777 
....77772222-....88880000 
.00-.31 
.06-.21 
.02-.19 
.03-.16 
• TYM test will be 
of particular value 
in clinical setting. 
Construct validity 
Hypothesis: 
1. TYM positively correlated with the Health 
of pain. n=111100004444 
MMMMuuuussssccccuuuulllloooosssskkkkeeeelllleeeettttaaaallll ppppaaaaiiiinnnn 
Internal (MSK) n=99999999 
consistency 
NNNNaaaammmmiiiinnnngggg 
VVVViiiissssuuuuoooossssppppaaaattttiiiiaaaallll 
5 
2 
....11112222-....77774444 
....77776666-....77776666 
.00-.11 
.04-.16 
aMinimum-maximum correlation of the item with its own scale 
bMinimum-maximum correlation of the items with other scales 
SSSSttttuuuuddddiiiieeeessss: No study 12% 
Primary 39% 
Secundary 41% 
Universitary 8% 
36% Men Women 64% 
Related Quality of Life (mental/physical 
component from SF-12) and with the Mini- 
Mental State Examination (MMSE). 
PPPPaaaaiiiinnnn iiiinnnntttteeeennnnssssiiiittttyyyy Significant differences 
44 
- Cronbach’s alpha 
coefficient. 
- Item-internal 
consistency/Item-discriminant 
2222.... TYM negatively correlated with anxiety 
43,78 
CCCCoooonnnnssssttttrrrruuuucccctttt vvvvaaaalllliiiiddddiiiittttyyyy 
PPPPaaaaiiiinnnn dddduuuurrrraaaattttiiiioooonnnn 
Mean MONTHS: 111100008888....5555 
(p<0,005) 
and/or depression (HADs test scores), sleep 
quality (Index-9 from MOS-sleep), duration 
and intensity of pain (VAS). 
3333.... Differences in the mean scores of the TYM 
FFFFiiiibbbbrrrroooommmmyyyyaaaallllggggiiiiaaaa (FM) 
n=55551111 
41,7 41,53 
42,54 
43 
42 
TYM score 
discriminant 
consistency. 
Structure of 
the TYM 
(SD:97.6) 
Mean VAS= 6666....6666 
(SD:1.9) 
test between groups of pain/no pain, type of 
pain, optimal/no optimal sleep (MOS-sleep), 
anxiety (HADs-A>10) and depression (HADs-D 
>10), and categories of intensity and 
40,53 
40,68 
40,32 
40,66 
41,22 
39,05 
40,24 
40,55 
40,27 
40,84 
40,63 
40,62 
40,04 
40,53 
41 
40 
- Exploratory 
Factor Analysis 
(EFA) after 
Varimax rotation. 
AAAAnnnnxxxxiiiieeeettttyyyy &&&& DDDDeeeepppprrrreeeessssssssiiiioooonnnn ((((HHHHAAAADDDDssss 0000-22221111)))) 
39 
duration of pain. 38,94 38 
Printed by 
HRQoL: Higher 
scores=Better QoL 
QoSleep: Higher scores=Worst 
QoSleep Pain duration

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CBT and Chronic Pain

  • 1. TEST YOUR MEMORY (TYM): A NEW TOOL TO EVALUATE THE COGNITIVE FUNCTION IN CHRONIC External Chair of Pain Grünenthal @observadolor PAIN PATIENTS. Conclusion Ojeda B1, Dueñas M1, Salazar A1, Torres LM2, Micó JA3, Failde I1. 1Preventive Medicine and Public Health Department, University of Cádiz, 2Anesthesiology-Critical Care and Pain Management, University Hospital, Cádiz, 3NeuroScience Department, University of Cádiz, Spain. Foundation-University of Cádiz. Background & Aims Taking into account the need for an instrument to assess cognitive function in chronic pain patients in routine clinical practice, and considering the good properties of the nnnneeeewwww TTTTYYYYMMMM WWWWhhhhaaaatttt aaaannnndddd hhhhoooowwww iiiissss tttthhhheeee TTTTYYYYMMMM tttteeeesssstttt???? Double sided sheet TTTTYYYYMMMM pppprrrrooooppppeeeerrrrttttiiiieeeessss ccccoooommmmppppaaaarrrreeeedddd ttttoooo MMMMMMMMSSSSEEEE CCCCPPPP ((((222255554444)))) CCCCoooonnnnttttrrrroooollllssss ((((77772222)))) NNNNPPPP ((((111100004444)))) MMMMSSSSKKKK ((((99999999)))) FFFFMMMM ((((55551111)))) iiiinnnnssssttttrrrruuuummmmeeeennnntttt to assess cognitive function, in this study wwwweeee pppprrrrooooppppoooosssseeeedddd ttttoooo aaaannnnaaaallllyyyyzzzzeeee tttthhhheeee vvvvaaaalllliiiiddddiiiittttyyyy aaaannnndddd rrrreeeelllliiiiaaaabbbbiiiilllliiiittttyyyy ooooffff tttthhhheeee SSSSppppaaaannnniiiisssshhhh vvvveeeerrrrssssiiiioooonnnn ooooffff tttthhhhiiiissss Includes different tasks to assess 10 cognitive domains Original structure (Brown, 2009) No. of Score TTTTYYYYMMMM MMMMeeeeaaaannnn ((((SSSSDDDD)))) IIIICCCC ((((99995555%%%%)))) MMMMiiiinnnniiiimmmmuuuummmm MMMMaaaaxxxxiiiimmmmuuuummmm FFFFlllloooooooorrrr ((((%%%%)))) 44440000....5555 ((((5555....5555)))) 33339999....8888-44441111....2222 22221111 55550000 0000....4444 44443333....9999 ((((4444....1111)))) 44443333-44444444....9999 33331111 55550000 1111....4444 44440000....5555 ((((6666....2222)))) 33339999....3333-44441111....7777 22221111 55550000 1 44440000....7777 ((((5555....4444)))) 33339999....6666-44441111....8888 22226666 44449999 3 44440000....2222 ((((4444....4444)))) 33338888....9999-44441111....44445555 33331111 55550000 2 • Test Your Memory is a quick and easy tool to qqqquuuueeeessssttttiiiioooonnnnnnnnaaaaiiiirrrreeee iiiinnnn ppppaaaattttiiiieeeennnnttttssss wwwwiiiitttthhhh cccchhhhrrrroooonnnniiiicccc ppppaaaaiiiinnnn 10 2 3 4 MMMMeeeetttthhhhoooodddd ffffrrrroooommmm tttthhhhrrrreeeeeeee ddddiiiiffffffffeeeerrrreeeennnntttt oooorrrriiiiggggiiiinnnnssss. items 1111.... OOOOrrrriiiieeeennnnttttaaaattttiiiioooonnnn 2222.... CCCCooooppppyyyyiiiinnnngggg.... 3333.... RRRReeeettttrrrrooooggggrrrraaaaddddeeee mmmmeeeemmmmoooorrrryyyy ((((sssseeeemmmmaaaannnnttttiiiicccc kkkknnnnoooowwwwlllleeeeddddggggeeee)))).... 4444.... CCCCaaaallllccccuuuullllaaaattttiiiioooonnnn.... 9 1 2 4 CCCCeeeeiiiilllliiiinnnngggg ((((%%%%)))) 1111....2222 5555....6666 1111....9999 1 2 MMSE Mean (SD) IC (95%) Minimum Maximum 26.9 (2.2) 26.7-27.2 17 30 29.1 (1.4) 28.8-29.4 24 30 26.9 (2.2) 26.5-27.4 17 30 27 (2.3) 26.5-27.4 20 30 26.8 (2.3) 26.2-27.5 19 30 evaluate cognitive function. • TYM test shows Instruments Cognitive function:Test Your Subjects 5555.... VVVVeeeerrrrbbbbaaaallll fffflllluuuueeeennnnccccyyyy.... 6666.... SSSSiiiimmmmiiiillllaaaarrrriiiittttiiiieeeessss.... 7777.... NNNNaaaammmmiiiinnnngggg.... 8888.... VVVViiiissssuuuuoooossssppppaaaattttiiiiaaaallll aaaabbbbiiiilllliiiittttyyyy 1111 &&&& 2222 ((((cccclllloooocccckkkk)))).... 9999.... AAAAnnnntttteeeerrrrooooggggrrrraaaaddddeeee mmmmeeeemmmmoooorrrryyyy. 1 2 5 2 1 4 4 5 7 6 IIIInnnntttteeeerrrrnnnnaaaallll ccccoooonnnnssssiiiisssstttteeeennnnccccyyyy Floor (%) Ceiling (%) 0.4 9.4 1.4 58.3 1 8.7 1 11.1 2 7.8 The higher scores represent better cognitive function. good psychometric properties in FFFFaaaaccccttttoooorrrr 8 factors identified Memory test (TYM) and Mini Mental State Examination (MMSE). Psychiatric disorders: Hospital Anxiety and depression scale 254 chronic pain (CP) patients (pain ≥3 months): 104 neuropathic (NP) 99 Musculoskeletal 11110000.... EEEExxxxeeeeccccuuuuttttiiiivvvveeee ((((aaaabbbbiiiilllliiiittttyyyy ttttoooo ccccoooommmmpppplllleeeetttteeee tttthhhheeee tttteeeesssstttt)))).... 1 5 28 50 Range of item correlations DDDDoooommmmaaaaiiiinnnnssss No. of items IIIItttteeeemmmm-iiiinnnntttteeeerrrrnnnnaaaallll ccccoooonnnnssssiiiisssstttteeeennnnccccyyyya Item-discriminant consistencyb (Cronbach’s alpha was 0.66) chronic pain patients. aaaannnnaaaallllyyyysssseeeessss: Eigenvalues ranging from 3,5 to1,1. Percentage of total variance acconted for 53%. (HADs) Sleep: Medical Outcome Study Sleep scale (MOS-Sleep scale). Quality of life: SF-12 v1 (MSK) 52 fibromyalgia (FM) DDDDeeeemmmmooooggggrrrraaaapppphhhhiiiicccc aaaannnndddd cccclllliiiinnnniiiiccccaaaallll cccchhhhaaaarrrraaaacccctttteeeerrrriiiissssttttiiiiccccssss ((((CCCCPPPP ppppaaaattttiiiieeeennnnttttssss:::: nnnn==== 222255554444)))) 72 control subjects free NNNNeeeeuuuurrrrooooppppaaaattttiiiicccc ppppaaaaiiiinnnn (NP) OOOOrrrriiiieeeennnnttttaaaattttiiiioooonnnn SSSSeeeemmmmaaaannnnttttiiiicccc kkkknnnnoooowwwwlllleeeeddddggggeeee CCCCaaaallllccccuuuullllaaaattttiiiioooonnnn SSSSiiiimmmmiiiillllaaaarrrriiiittttiiiieeeessss 9 2 4 2 ....22220000-....55550000 ....77776666-....77777777 ....55551111-....77777777 ....77772222-....88880000 .00-.31 .06-.21 .02-.19 .03-.16 • TYM test will be of particular value in clinical setting. Construct validity Hypothesis: 1. TYM positively correlated with the Health of pain. n=111100004444 MMMMuuuussssccccuuuulllloooosssskkkkeeeelllleeeettttaaaallll ppppaaaaiiiinnnn Internal (MSK) n=99999999 consistency NNNNaaaammmmiiiinnnngggg VVVViiiissssuuuuoooossssppppaaaattttiiiiaaaallll 5 2 ....11112222-....77774444 ....77776666-....77776666 .00-.11 .04-.16 aMinimum-maximum correlation of the item with its own scale bMinimum-maximum correlation of the items with other scales SSSSttttuuuuddddiiiieeeessss: No study 12% Primary 39% Secundary 41% Universitary 8% 36% Men Women 64% Related Quality of Life (mental/physical component from SF-12) and with the Mini- Mental State Examination (MMSE). PPPPaaaaiiiinnnn iiiinnnntttteeeennnnssssiiiittttyyyy Significant differences 44 - Cronbach’s alpha coefficient. - Item-internal consistency/Item-discriminant 2222.... TYM negatively correlated with anxiety 43,78 CCCCoooonnnnssssttttrrrruuuucccctttt vvvvaaaalllliiiiddddiiiittttyyyy PPPPaaaaiiiinnnn dddduuuurrrraaaattttiiiioooonnnn Mean MONTHS: 111100008888....5555 (p<0,005) and/or depression (HADs test scores), sleep quality (Index-9 from MOS-sleep), duration and intensity of pain (VAS). 3333.... Differences in the mean scores of the TYM FFFFiiiibbbbrrrroooommmmyyyyaaaallllggggiiiiaaaa (FM) n=55551111 41,7 41,53 42,54 43 42 TYM score discriminant consistency. Structure of the TYM (SD:97.6) Mean VAS= 6666....6666 (SD:1.9) test between groups of pain/no pain, type of pain, optimal/no optimal sleep (MOS-sleep), anxiety (HADs-A>10) and depression (HADs-D >10), and categories of intensity and 40,53 40,68 40,32 40,66 41,22 39,05 40,24 40,55 40,27 40,84 40,63 40,62 40,04 40,53 41 40 - Exploratory Factor Analysis (EFA) after Varimax rotation. AAAAnnnnxxxxiiiieeeettttyyyy &&&& DDDDeeeepppprrrreeeessssssssiiiioooonnnn ((((HHHHAAAADDDDssss 0000-22221111)))) 39 duration of pain. 38,94 38 Printed by HRQoL: Higher scores=Better QoL QoSleep: Higher scores=Worst QoSleep Pain duration