1. CHLOROBUTANOL - COMPOUND
Also known as: Chlorbutol, CHLORETONE,
Acetonchloroform, Acetochlorone,
Chlorbutanol, Coliquifilm, Chloreton, Chlortran,
Clortran
Molecular Formula: C4H7Cl3O Molecular
Weight: 177.45678 InChIKey: OSASVXMJTNO
KOY-UHFFFAOYSA-N
A colorless to white crystalline compound with
a camphoraceous odor and taste. It is a widely
used preservative in various pharmaceutical
solutions, especially injectables. Also, it is an
active ingredient in certain oral sedatives and
topical anesthetics. From: MeSH
2. SHOW SUBCONTENT TITLESTABLE OF CONTENTS
Identification
Related Records
Use and Manufacturing
Pharmacology
Biomedical Effects and Toxicity
Safety and Handling
Exposure Standards and Regulations
Monitoring and Analysis Methods
Literature
Patents
Biological Test Results
Classification
Chemical and Physical Properties
5. RELATED COMPOUNDS WITH ANNOTATION
hexylene glycol
1,1,1-trifluoro-
-2-propan...
BM 567
hexafluoroisopropanol
3-hydroxy-3-met-
hylbutene
6. USE AND MANUFACTURING
Prepn: prepd by action of powdered potassium
hydroxide or of potassium ethoxide solution on
mixture of chloroform & acetone .
By action of potassium hydroxide on a solution of
chloroform and acetone.
The para and ortho positions of phenols condense
at the carbonyl group of acetone to make
bisphenols... If the H atom is activated, ClCH-
compounds add to the carbonyl group in the
presence of stong base; chloroform gives
chloretone.
7. PHARMACOLOGY
Preservatives, Pharmaceutical - Substances
added to pharmaceutical preparations to protect
them from chemical change or microbial action.
They include ANTI-BACTERIAL AGENTS and
antioxidants.
(Pharmacological Action, Therapeutic Uses, Drug
Warning, Drug Idiosyncracies, Minimum/Potential
Fatal Human Dose)
8. BIOMEDICAL EFFECTS AND TOXICITY
SOLN CONTAINING...0.4%
CHLOROBUTANOL...UNDER CONTACT
LENS...LEFT ON EYE FOR SEVERAL
MIN...UNCOMFORTABLE KERATITIS
EPITHELIALIS HAS RESULTED, WITH FOGGING
OF VISION, HALOES AROUND LIGHTS, &
FOREIGN-BODY TYPE OF DISCOMFORT
BEGINNING WITHIN HR & BECOMING
WORSE...EYES HAVE RECOVERED
SPONTANEOUSLY & COMPLETELY IN DAY OR
TWO.
This substance may be habit forming
9. EXPOSURE STANDARDS AND REGULATIONS
FDA Requirements
Manufacturers, packers, and distributors of drug
and drug products for human use are responsible
for complying with the labeling, certification, and
usage requirements as prescribed by the Federal
Food, Drug, and Cosmetic Act, as amended (secs
201-902, 52 Stat. 1040 et seq., as amended; 21
U.S.C. 321-392).
Chloretone is a chemical derivative of chloral,
named in section 502(d) of the Federal Food, Drug,
and Cosmetic Act and is hereby designated as
habit forming.
10. MONITORING AND ANALYSIS METHODS
Analytic Laboratory Methods
AOAC Method 936.17. Chlorinated hydrocarbons in
drugs. Infrared Spectrophotometric Method.
/Chlorinated hydrocarbons
AOAC Method 967.29. Chlorobutanol in drugs. Gas
chromatographic and infrared methods.
/Chlorobutanol
11. COMPUTED PROPERTIES
EP1032403 5-3-2012 NUTRITIONAL
SUPPLEMENT FOR
CEREBRAL
METABOLIC
INSUFFICIENCIES
EP0894143 4-19-2012 VMP-LIKE
SEQUENCES OF
PATHOGENIC
BORRELIA VMP-LIKE
SEQUENCES OF
PATHOGENIC
BORRELIA
EP0845977 12-22-2011 CLEAR COSMETIC
GEL COMPOSITION
CLEAR COSMETIC
GEL COMPOSITION
12. CHEMICAL AND PHYSICAL PROPERTIES
NEEDLES (WATER+1)
Crystals
COLORLESS TO WHITE
Colorless to white crystals
Odor
Camphor odor
Characteristic odor
Taste
Camphor taste
Characteristic taste
13. SOLUBILITIES
HOT WATER INSOL IN COLD WATER, SOL IN
1 G IN 125 ML WATER; SOL IN VOLATILE OILS
Easily sol in hot water; one gram dissolves in 1 ml
alcohol, 10 ml glycerol; sol in chloroform, ether,
acetone, petr ether, glacial acetic acid, oils.
Soluble in alcohol and glycerol, hot water, ether,
chloroform, and volatile oils.
Soluble in ethanol, ethyl ether, and acetone.
In water, 8,000 mg/l @ 20 deg C
