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Pediatric rotation-Al Maqased Hospital 
This presentation was prepared by: 
LAYTH HELWA 
Craniopharyngioma 
AUTUMN-2014
Craniopharyngiomas are dysontogenic tumors with benign histology and malignant 
behavior.
adamantinomatous papillary
Epidemiology 
1- The estimated incidence is 1.4 cases per million 
children per year. 
2- In children, craniopharyngioma r...
History and Physical Examination 
The most common presenting symptoms are 
headache (55-86%). 
endocrine dysfunction (66-9...
Imaging 
The characteristic imaging finding of 
craniopharyngioma 
in a child is an enhancing suprasellar mass that 
is ca...
Treatment 
Essentially, 2 main management options are 
available for craniopharyngiomas: 
(1) attempt at gross total resec...
Neurosurg 119:106–112, 2013 
106 J Neurosurg / Volume 119 / July 2013 
©AANS, 2013 
Molecular oncogenesis of craniopharyng...
Craniopharyngioma-full lecture
Craniopharyngioma-full lecture
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Craniopharyngioma-full lecture

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full lecture about craniopharyngioma
usmle review....

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Craniopharyngioma-full lecture

  1. 1. Pediatric rotation-Al Maqased Hospital This presentation was prepared by: LAYTH HELWA Craniopharyngioma AUTUMN-2014
  2. 2. Craniopharyngiomas are dysontogenic tumors with benign histology and malignant behavior.
  3. 3. adamantinomatous papillary
  4. 4. Epidemiology 1- The estimated incidence is 1.4 cases per million children per year. 2- In children, craniopharyngioma represents 5-10% of all intracranial tumors . 3- A slight male predominance exists in all age groups (55%). 4- Craniopharyngiomas have a bimodal age distribution pattern, with a peak between ages 5 and 14 years and in adults older than 65 years, although there reports involving all age groups.
  5. 5. History and Physical Examination The most common presenting symptoms are headache (55-86%). endocrine dysfunction (66-90%) visual disturbances (37-68%). Neurologic examination General examination Hypothyroidsm-40 % -Puffiness and non-pitting edema -Slow return phase of deep tendon reflexes -Hypoventilation and decrease in cardiac output -Pericardial and pleural effusions -Constipation -Psychiatric change Adrenal insufficiency 25% -Hypovolemia. -Decreased cardiac output. -Fatigue. -Cardiac arrhythmias due to hyperkalemia
  6. 6. Imaging The characteristic imaging finding of craniopharyngioma in a child is an enhancing suprasellar mass that is calcified and cystic on CT. When two out of these three features are present, craniopharyngioma is still the most likely diagnosis. The tumor usually demonstrates T1 high intensity on MR, reflecting the protein or cholesterol content of the “motor oil-like” fluid found in the tumor cysts . Rarely on plain skull film, craniopharyngioma may be suspected by the presence of sellar or suprasellar calcifications.
  7. 7. Treatment Essentially, 2 main management options are available for craniopharyngiomas: (1) attempt at gross total resection or (2) planned limited surgery followed by radiotherapy. Inflammatory cytokines and biomodulation
  8. 8. Neurosurg 119:106–112, 2013 106 J Neurosurg / Volume 119 / July 2013 ©AANS, 2013 Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies.

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