Citocinas

Citocinas Dr. José Antonio Ortega Martell Escuela de Medicina UAEH

Definición ,[object Object],[object Object],[object Object]

Principales características ,[object Object],[object Object],[object Object],[object Object]

Tipos de Interferones ,[object Object],[object Object]

Interferón alfa ,[object Object],[object Object],[object Object],[object Object],[object Object]

Interferón beta ,[object Object],[object Object],[object Object],[object Object]

Y Y JAK JAK Y Y Y -P P- Y Y -P P-Y Y Y -P JAK JAK P- Y -P P- Y Proteína STAT transcripción STAT Gen de citocinas

Mecanismo de acción ,[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Mecanismo de acción

Activación de respuesta celular ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Usos clínicos de IFN tipo I

Interferones ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Interferones.

Interferón Gamma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IL-12 ,[object Object],[object Object]

Usos clínicos Interferón  ,[object Object],[object Object],[object Object],[object Object],[object Object]

Interleucina 1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Interleucina 7 ,[object Object],[object Object],[object Object]

Factor alfa de necrosis tumoral TNF - 

TNF-  ,[object Object],[object Object],[object Object],[object Object],[object Object]

TNF-  ,[object Object],[object Object],[object Object]

TNF-  ,[object Object],[object Object],[object Object],[object Object]

Artritis Reumatoide Cápsula Cartílago m. sinovial Espacio interarticular Pannus Engrosamiento

Bloqueo TNF-  e Inflamación

Bloqueo de receptores Agonista competitivo Anticuerpo anti receptor

Factor beta de crecimiento y transformación TGF - 

TGF-  ,[object Object],[object Object],[object Object],[object Object]

TGF-  ,[object Object],[object Object],[object Object],[object Object],[object Object]

Factor estimulante de colonias de granulocitos y monocitos - macrófagos GM - CSF

GM – CSF ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GM – CSF ,[object Object],[object Object],[object Object],[object Object],[object Object]

Capacidades afectadas por la Citocina “A” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Amar Odiar

Citocinas

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Citocinas