3. -younger individuals
-associated with insulin-resistant states
(eg:DM,obesity,PCOS) increased levels of insulin
and/or insulin-like growth factor are thought to
stimulate epidermal and dermal proliferation.
-Similarly,skin tags(acrochondrons),which are
pedunculated outgrowths of normal skin,are also
commonly present on regions,affected byn AN
4. underlying neoplasms ,especially of the GIT
and genitourinary tracts.
The sudden appearance of such skin changes
in middle-aged or elderly pt is suggestive of
underlying malignancy.
These patient are not obese(but instead may
have lost weight) and lesions can occur in
uncomon areas(eg.mucous membrances,
palms,soles.)
5.
6.
7. PCT is a blistering skin disease of sun-exposed areas
in those with a history of :
Liver disease (hepatitis C, alcoholism)
Estrogen use
Iron overload (hemochromatosis)
Look for involvement of the
backs of the hands and the face.
PCT is a hypersensitivity
of the skin to abnormal
porphyrins when they are
exposed to light.
9. The most accurate diagnostic test is
increased uroporphyrins in a 24-hour urine
collection.
It is a deficiency of uroporphyrin
decarboxylase activity.
Correct the underlying cause (stop alcohol,
stop estrogens) and remove iron with
phlebotomy.
11. Seborrheic dermatitis is a hypersensitivity reaction
to a dermal infection with noninvasive dermatophyte
organisms.
This is why both topical steroids (hydrocortisone,
alclometasone) and antifungal agents (ketoconazole)
are useful.
It is increased in:
• AIDS
• Parkinson disease
The term seborrheic is synonymous with benign
16. These lesions are extremely common in the
elderly.
They are hyperpigmented lesions commonly
referred to as liver spots.They give a "stuck on"
appearance.
Although they may look like melanoma to some
people, seborrheic keratoses have no
premalignant potential.They do not transform
into melanoma.
They are removed with cryotherapy, surgery, or
laser for cosmetic reasons.
