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Reakcije glikolize i krebsovog ciklusa

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Reakcije glikolize i krebsovog ciklusa

  1. 1. Reakcije glikolize i Krebsovog ciklusa
  2. 2. Glukoza ATP ADP Fruktozo-1,6-bisfosfat (FRU-1,6-BisP) 1 4 GLIKOLIZA - I faza 1 Dihidroksiaceton fosfat (DHA-P) Gliceraldehid 3-fosfat (GLA--3P) 5 ADP ATP 3
  3. 3. GliceraldehidDihidroksiaceton fosfat (DHA-P) 3-fosfat (GLA-3-P) 1,3-bisfosfoglicerat 3-fosfoglicerat 5 2 GLIKOLIZA - II faza 4 FOSFORILACIJA NA NIVOU SUPSTRATA X 2 NADH +H + 6 + NAD P i+ ATP ADP 7 Fosfoenolpiruvat (PEP) Piruvat (PGK) C CH 3 COO O H2O 9 ADP 10 ATP
  4. 4. Piruvat Laktat dehidrogenaza NAD + L-laktat C COO CH3 O 1 2 3 HO HC CH3 COO 3 2 1 MLE^NOKISELINSKA FERMENTACIJA Mehanizam delovanja Laktat dehidrogenaze NADH + H + Glikoliza
  5. 5. EtanolAcetaldehidPiruvat Glikoliza Alkoholna dehidrogenaza NAD + C CH3 OHH HCO2 + H ALKOHOLNA FERMENTACIJA NADH + H + C COO CH3 O C H CH3 O
  6. 6. 3 1 PIRUVAT COO C O CH3 CO2 Acetil-S-CoA CoAS O CCH3 HS CoA SUMA REAKCIJA OKSIDATIVNE DEKARBOKSILACIJE PIRUVATA Acetil-S-CoA HS-CoA +++ NADH CO2 + NAD+Piruvat + H +
  7. 7. Acetil-S-CoA O C S-CoACH3 OKSALACETAT CITRAT NADH + H + OKSALSUKCINAT IZOCITRAT a-KETOGLUTARAT CO2 4 SUKCINAT GTP FADH2 6 MALAT 8 7 4C 2C 6C 6C 6C 5C NADH + H + CO2 4C 4C NADH + H + Ciklus limunske kiseline
  8. 8. 2x FADH2 2x (NADH + H ) + ENERGETSKI BILANS KATABOLIZMA GLUKOZE GLUKOZA ANAEROBNI USLOVI AEROBNI USLOVI 2x (ATP) PIRUVAT2x Glikoliza LAKTAT2x Ukupni prinos: 2x ATP GLUKOZA 2x (ATP) PIRUVAT2x Ciklus limunske kiseline 2x (3 NADH + H ) + 2x (CO2) 2x (GTP)= 2x (ATP) Respiratorni lanac Oksidativna fosforilacija 2x (NADH + H ) + 4x (CO2) 34x (ATP) ACETIL-S-CoA2x 6x (H2O) C6H12O6 + 6O2 = 6CO2 + 6H2O Ukupni prinos: 38 x ATP Glikoliza Oksidativna dekarboksilacija piruvata Oksidativna fosforilacija Ciklus limunske kiseline
  9. 9. Spolja{nja membrana mitohondrija Unutra{nja membrana mitohondrija Medjumembranski prostor Matriks Visoka + H ATPADP + Pi Niska + H + H e + ++ ++ + ++ + H2O2 O2 1 + H + H + H + ++ ++ + + + + ++ ++ ++ ++ ++ ++ ++ ++ + POVEZIVANJE PROCESA PRENOSA ELEKTRONA I SINTEZE ATP-a

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