Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Niosomes

2,622 views

Published on

Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. The vesicle is composed of a bilayer of non-ionic surface active agents and hence the name niosomes.

Published in: Education
  • Be the first to comment

Niosomes

  1. 1. NIOSOMES By-Lovnish Thakur
  2. 2.  Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. The vesicle is composed of a bilayer of non-ionic surface active agents and hence the name niosomes. Nios = non ionic surfactant somes = vesicles 
  3. 3.  They are vesicular systems similar to liposomes that can be used as carriers of hydrophilic, ampiphilic and lipophilic drugs.  The niosomes are very small, and microscopic in size.  Their size lies in the nanometric scale. www.pharmatutor.org
  4. 4.  Most surface active agents when immersed in water yield micellar structures, however some surfactants can yield bilayer vesicles which are niosomes. Niosomes may be-  unilamellar  multilamellar
  5. 5. Small Unilamellar Vesicle (SUV) Large Unilamellar Vesicle (LUV) Multilamellar Vesicle (MLV) Typical Size Ranges: SLV: 20-50 nm – MLV:100-1000 nm
  6. 6. MECHANISMS OF NIOSOMAL SKIN DELIVERY Noisomes interact with stratum corneum with aggregation, fusion and adhesion to the cell surface which causes a high thermodynamic activity gradient of the drug at the vesicle-stratum corneum surface, which is the driving force for the penetration of lipophilic drugs across the stratum corneum New smaller vesicles are formed in skin Niosomes diffuse from the stratum corneum layer of skin as a whole
  7. 7. NIOSOMES V/S LIPOSOMES .Niosomes do not have any of these problems: 1) Niosomes are made of uncharged single-chain surfactant molecules 2) Structure of niosomes is different from that of liposomes Liposomes face problems such as: 1) expensive 2) chemically unstable
  8. 8. ADVANTAGES OF NIOSOMES  Osmotically active  Increase the stability of the entrapped drug  Handling and storage of surfactants do not require any special conditions.  Can increase the oral bioavailability of drugs  Can enhance the skin penetration of drugs  can be used for oral, parenteral as well topical use.  The surfactants are biodegradable, biocompatible, and non-immunogenic .  Improve the therapeutic performance of the drug by protecting it from the biological environment and restricting effects to target cells
  9. 9. CONCLUSION  Niosomes are thoughts to be better candidates drug delivery as compared to liposomes due to various factors like cost, stability etc.  Various type of drug deliveries can be possible using niosomes like targeting, ophthalmic, topical, parentral etc.
  10. 10.  file:///E:/M.PHARM%202SEM/Niosomes/niosomess/Niosome.htm  Book- Controlled and Novel Drug Dilevery by N.K. JAIN  Malhotra, M. & Jain, N.K., (1994). Niosomes as drug carriers. Ind Drugs, Vol. 31  Azeem, A.; Anwer, M.K. & Talegaonkar, S., (2009).  Niosomes in sustained and targeted drug delivery: some recent advances. J Drug Target, Vol. 17  NIOSOME: A PROMISING PHARMACEUTICAL DRUG DELIVERY(http://www.ijpda.com/admin/uploads/AzYyEr.pdf)
  11. 11. Thank You

×