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POWERPOINT®
LECTURE SLIDE PRESENTATION
by ZARA OAKES, MS, The University of Texas at Austin
Additional text by J Padilla exclusively for physiology at ECC
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
HUMAN PHYSIOLOGY
AN INTEGRATED APPROACH FOURTH EDITION
DEE UNGLAUB SILVERTHORN
UNIT 1UNIT 1
PART A
3 Compartmentation:
Cells and Tissues
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Three Major Body Cavities
Figure 3-1
The body is
divided into
various cavities
but not all
compartments
have walls or
are completely
enclosed
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Lumens of Hollow Organs
 Hollow organs- contain a space filled with something
other than the organ’s tissue.
 Heart
 Lungs
 Blood vessels
 Intestines
 Lumen – interior of a hollow organ
 Fluid-filled interior
 Not the internal environment- as is in the GI tract
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Functional Compartments
 Extracellular fluid- found outside of organ tissue
 Plasma-fluid of blood
 Interstitial fluid- fluid between blood vessels and
tissue cells
 Intracellular fluid-fluid inside tissue cells
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-2
Body Fluid Compartments
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-3
Cell Membrane: Overview
Membranes in the body may be macroscopic or
microscopic and serve different functions
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Cell Membrane: Function
 Physical barrier- separates intracellular and
extracellular fluid
 Gateway for exchange- controls what enters and
leaves the cell
 Communication- surface proteins respond and
recognize other molecules which can change cell
activity
 Cell structure- cell shape is maintained by
cytoskeletal proteins attached to membrane proteins.
Membrane proteins also form cell junctions
 Phospholipid bilayer- composed of mostly lipids
and proteins, it’s hydrophobic and hydrophilic
regions assist in controlling transport.
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-4
Cell Membrane: Structure
The fluid mosaic model of a biological membrane
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Cell Membrane: Composition
 Lipids
 Phospolipids – a glycerol molecule with one phosphate and two fatty
acid tails- makes up a large percentage of the membrane.
 Cholesterols- imbedded in the bilayer it stabilizes the membrane and
reduces it’s freezing point.
 Proteins
 Integral – transmembrane protein, serves as a channel
 Peripheral – side proteins that may be enzyme of cytoskeleton
anchors
 Lipid-anchored – associate with sphingolipids to form lipid rafts that
may attract other proteins or enzymes
 Carbohydrates
 Glycolipids- carbohydrates and fatty acids
 Glycoprotiens-carbohydrates and proteins
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-5a
Cell Membrane: Formation
Phospholipid molecules are composed of two fatty acid
chains, one glycerol molecule, & one phosphate group
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Cell Membrane: Formation
Figure 3-5b
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-6
Cell Membrane: Proteins
The three types of membrane proteins: integral,
peripheral, and lipid-anchored
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-9
Cell Membrane
Concept Map of cell membrane components
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-10
The cell membrane covers cells of
various sizes, shapes, and functions
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Cell Compartments
 Cytoplasm- The space between the plasma
membrane and the nucleus
 Cytosol - the jelly like substance that suspends the
organelles
 Inclusions - a non-membranous organelle or insoluble
particles
 Organelles - cell structures with specific function-
“small organs”
 Nucleus- contains the genetic information for the cell
as chromatin, the nucleolus, and nucleoplasm.
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-11
Cell Compartments
A map for the
study of cell
structure
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Organelle “Factory” and summary chart
 See board drawing and table on board
 Review on your own the functions and structures of
the following cell organelles (see fig 3:12):
 Inclusions (3-types)
 Centrioles, Cillia, & Flagella
 Cytoplasmic protein fibers (3 sizes)
 Cytoskeleton
 Mitochondria
 Smooth/Rough Endoplasmic Reticulum
 Cytoplasmic Vesicles
 Nucleus
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Primary Tissue Types
 Epithelial- major functions: are protection, exchange,
and lining cavities.
 Connective- major functions are: support, storage,
communication, immunity.
 Muscle- major functions are: posture, movement, heat
production, support and protection.
 Nerve- major function is communication and control,
information processing.
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Epithelial Tissue: Structure
 Basal lamina
 Basement membrane
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Epithelial Tissue: Function
 Exchange – quick
movement of molecules
 Transport – move from
one side to another and
process
 Ciliated – move substances
in the extracellular matrix
 Protective – multiple
layers, quickly regenerates
 Secretory – produces
substances secreted into the
extracellular matrix or
outside the body.
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Exchange Epithelia
 Single cell layer of flat cells that allow molecules to cross through at different rates,
increase surface area with microvilli.
 Rapid transport -
 Oxygen -
 Carbon dioxide -
 Ions and fluids -
 Capillaries and lung alveoli -
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Transporting Epithelia
 single layer or cuboidal or
columnar cells, take in a molecule
from a lumen and transport it into
the blood stream.
 Exchange of ions and
nutrients -
 Tight junctions -
 Intestine and kidney -
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Ciliated and Protective Epithelia
 apical cilia allow more the movement of substance on the surface of the
cell, like the ovum or mucus
 Ciliated epithelium -
 Trachea -
 Sweep mucous out -
 Protective epithelium -
 multiple layers and in skin, serve for protection. Cell have a high
regenerative ability.
 Skin -
 Prevent exchange -
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Secretory Epithelia
 contain goblet cells and
cells that form the different
endocrine or exocrine
glands in the body
 Exocrine tissues
 Mucous glands
 Goblet cells
 Secreted externally via
ducts
 Endocrine tissues
 Hormones
 Secreted to ECF and blood
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-28 (1 of 3)
Secretory Epithelia
Development of endocrine and exocrine glands
from epithelium
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Connective Tissues: Structure
 Support and barriers – strong high collagen content
allow to withstand forces
 Ground substance – varies in amount of water and
changes the consistency of the type of connecitve
tissue
 Cells – have a wide variety of functions
 Fixed – imbedded in a dense ground substance
 Mobile – blood cells surrounded by a fluid ground
substance such as plasma, are able to enter or leave the
blood stream.
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Connective Tissues: Structure
 Fibers and their functions- found in the ground substance, the
different ratios of each give each type of connective tissue their
unique characteristics.
 Fibroblast cells - produce the fibers and ground substance
 Collagen – has a stronger tensile strength than steel, there are
12 variations, is most abundant in the body.
 Elastin – gives elasticity to tissues
 Fibrillin – combines with elastin to give support to elastic
organs.
 Fibronectin – stick to extracellular matrix of cells and helps in
forming blood clots
 Reticular fibers- form a network of supportive fibers for cells
composed of free cells as in bone marrow, spleen, and
lymphnodes
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Connective Tissues: Types
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Cells and Fibers of Loose Connective Tissue
Figure 3-29 (1 of 2)
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Various Connective Tissue Types
 Strength or flexibility
 Tendons and ligaments
 Collagen dominates
 Adipose connective tissue
 White
 Single droplet
 Brown
 Multiple droplets
 Blood
 Plasma matrix
 Free blood cells
 Cartilage
 Light and flexible
 Trachea and ears
 Bone
 Calcified
 Rigid
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Muscle Tissues
 Contractile
 Force and movement
 Signal conduction
 Types
 Cardiac
 Smooth
 Skeletal
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Nervous Tissues
 Neurons send signals
 Excitable
 Electrical
 Chemical
 Glial cells support
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Cell Death and Replacement
 Apoptosis- cell death not caused by injury or other
external reasons
 Normal cell replacement – during body formation, or in
normal body function cells reach a life limit and die
 Programmed cell death - induced by the cell without
disturbing adjacent cells; “cell suicide”
 Stem cells – undifferentiated cells that can become
any cell needed in the body, totipotent, puripotent, and
mulitpotent
 Role in cell replacement – certain tissues have
multipotent stem cells that can replace cells
 Research uses and potential – need to find a good
source of stem cells, face many ethical issues
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Organs
 Groups of tissues with related function – each
contains the four types of tissues in various ratios
 Epidermal tissue (skin) -
 Multiple cell layers – epidermis, dermis,
hypodermis
 Multiple tissue types – epitheial, connective,
muscular, nervous
 Multiple functions – protection, metabolism,
temperature regulation, water proofing, blood
storage, insulation, excretion, sensory organ
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings UN 3-1 - Overview
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings
Integument System Functions
1. Protection
2. Insulation
3. Water proofing
4. Temperature regulation
5. Excretion
6. Cutaneous Sensory organ
7. Metabolism
8. Blood reservoir

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Compartments & cells

  • 1. POWERPOINT® LECTURE SLIDE PRESENTATION by ZARA OAKES, MS, The University of Texas at Austin Additional text by J Padilla exclusively for physiology at ECC Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings HUMAN PHYSIOLOGY AN INTEGRATED APPROACH FOURTH EDITION DEE UNGLAUB SILVERTHORN UNIT 1UNIT 1 PART A 3 Compartmentation: Cells and Tissues
  • 2. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Three Major Body Cavities Figure 3-1 The body is divided into various cavities but not all compartments have walls or are completely enclosed
  • 3. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Lumens of Hollow Organs  Hollow organs- contain a space filled with something other than the organ’s tissue.  Heart  Lungs  Blood vessels  Intestines  Lumen – interior of a hollow organ  Fluid-filled interior  Not the internal environment- as is in the GI tract
  • 4. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Functional Compartments  Extracellular fluid- found outside of organ tissue  Plasma-fluid of blood  Interstitial fluid- fluid between blood vessels and tissue cells  Intracellular fluid-fluid inside tissue cells
  • 5. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-2 Body Fluid Compartments
  • 6. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-3 Cell Membrane: Overview Membranes in the body may be macroscopic or microscopic and serve different functions
  • 7. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Cell Membrane: Function  Physical barrier- separates intracellular and extracellular fluid  Gateway for exchange- controls what enters and leaves the cell  Communication- surface proteins respond and recognize other molecules which can change cell activity  Cell structure- cell shape is maintained by cytoskeletal proteins attached to membrane proteins. Membrane proteins also form cell junctions  Phospholipid bilayer- composed of mostly lipids and proteins, it’s hydrophobic and hydrophilic regions assist in controlling transport.
  • 8. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-4 Cell Membrane: Structure The fluid mosaic model of a biological membrane
  • 9. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Cell Membrane: Composition  Lipids  Phospolipids – a glycerol molecule with one phosphate and two fatty acid tails- makes up a large percentage of the membrane.  Cholesterols- imbedded in the bilayer it stabilizes the membrane and reduces it’s freezing point.  Proteins  Integral – transmembrane protein, serves as a channel  Peripheral – side proteins that may be enzyme of cytoskeleton anchors  Lipid-anchored – associate with sphingolipids to form lipid rafts that may attract other proteins or enzymes  Carbohydrates  Glycolipids- carbohydrates and fatty acids  Glycoprotiens-carbohydrates and proteins
  • 10. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-5a Cell Membrane: Formation Phospholipid molecules are composed of two fatty acid chains, one glycerol molecule, & one phosphate group
  • 11. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Cell Membrane: Formation Figure 3-5b
  • 12. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-6 Cell Membrane: Proteins The three types of membrane proteins: integral, peripheral, and lipid-anchored
  • 13. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-9 Cell Membrane Concept Map of cell membrane components
  • 14. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-10 The cell membrane covers cells of various sizes, shapes, and functions
  • 15. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Cell Compartments  Cytoplasm- The space between the plasma membrane and the nucleus  Cytosol - the jelly like substance that suspends the organelles  Inclusions - a non-membranous organelle or insoluble particles  Organelles - cell structures with specific function- “small organs”  Nucleus- contains the genetic information for the cell as chromatin, the nucleolus, and nucleoplasm.
  • 16. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-11 Cell Compartments A map for the study of cell structure
  • 17. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Organelle “Factory” and summary chart  See board drawing and table on board  Review on your own the functions and structures of the following cell organelles (see fig 3:12):  Inclusions (3-types)  Centrioles, Cillia, & Flagella  Cytoplasmic protein fibers (3 sizes)  Cytoskeleton  Mitochondria  Smooth/Rough Endoplasmic Reticulum  Cytoplasmic Vesicles  Nucleus
  • 18. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Primary Tissue Types  Epithelial- major functions: are protection, exchange, and lining cavities.  Connective- major functions are: support, storage, communication, immunity.  Muscle- major functions are: posture, movement, heat production, support and protection.  Nerve- major function is communication and control, information processing.
  • 19. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Epithelial Tissue: Structure  Basal lamina  Basement membrane
  • 20. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Epithelial Tissue: Function  Exchange – quick movement of molecules  Transport – move from one side to another and process  Ciliated – move substances in the extracellular matrix  Protective – multiple layers, quickly regenerates  Secretory – produces substances secreted into the extracellular matrix or outside the body.
  • 21. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Exchange Epithelia  Single cell layer of flat cells that allow molecules to cross through at different rates, increase surface area with microvilli.  Rapid transport -  Oxygen -  Carbon dioxide -  Ions and fluids -  Capillaries and lung alveoli -
  • 22. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Transporting Epithelia  single layer or cuboidal or columnar cells, take in a molecule from a lumen and transport it into the blood stream.  Exchange of ions and nutrients -  Tight junctions -  Intestine and kidney -
  • 23. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Ciliated and Protective Epithelia  apical cilia allow more the movement of substance on the surface of the cell, like the ovum or mucus  Ciliated epithelium -  Trachea -  Sweep mucous out -  Protective epithelium -  multiple layers and in skin, serve for protection. Cell have a high regenerative ability.  Skin -  Prevent exchange -
  • 24. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Secretory Epithelia  contain goblet cells and cells that form the different endocrine or exocrine glands in the body  Exocrine tissues  Mucous glands  Goblet cells  Secreted externally via ducts  Endocrine tissues  Hormones  Secreted to ECF and blood
  • 25. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 3-28 (1 of 3) Secretory Epithelia Development of endocrine and exocrine glands from epithelium
  • 26. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Connective Tissues: Structure  Support and barriers – strong high collagen content allow to withstand forces  Ground substance – varies in amount of water and changes the consistency of the type of connecitve tissue  Cells – have a wide variety of functions  Fixed – imbedded in a dense ground substance  Mobile – blood cells surrounded by a fluid ground substance such as plasma, are able to enter or leave the blood stream.
  • 27. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Connective Tissues: Structure  Fibers and their functions- found in the ground substance, the different ratios of each give each type of connective tissue their unique characteristics.  Fibroblast cells - produce the fibers and ground substance  Collagen – has a stronger tensile strength than steel, there are 12 variations, is most abundant in the body.  Elastin – gives elasticity to tissues  Fibrillin – combines with elastin to give support to elastic organs.  Fibronectin – stick to extracellular matrix of cells and helps in forming blood clots  Reticular fibers- form a network of supportive fibers for cells composed of free cells as in bone marrow, spleen, and lymphnodes
  • 28. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Connective Tissues: Types
  • 29. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Cells and Fibers of Loose Connective Tissue Figure 3-29 (1 of 2)
  • 30. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Various Connective Tissue Types  Strength or flexibility  Tendons and ligaments  Collagen dominates  Adipose connective tissue  White  Single droplet  Brown  Multiple droplets  Blood  Plasma matrix  Free blood cells  Cartilage  Light and flexible  Trachea and ears  Bone  Calcified  Rigid
  • 31. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Muscle Tissues  Contractile  Force and movement  Signal conduction  Types  Cardiac  Smooth  Skeletal
  • 32. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Nervous Tissues  Neurons send signals  Excitable  Electrical  Chemical  Glial cells support
  • 33. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Cell Death and Replacement  Apoptosis- cell death not caused by injury or other external reasons  Normal cell replacement – during body formation, or in normal body function cells reach a life limit and die  Programmed cell death - induced by the cell without disturbing adjacent cells; “cell suicide”  Stem cells – undifferentiated cells that can become any cell needed in the body, totipotent, puripotent, and mulitpotent  Role in cell replacement – certain tissues have multipotent stem cells that can replace cells  Research uses and potential – need to find a good source of stem cells, face many ethical issues
  • 34. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Organs  Groups of tissues with related function – each contains the four types of tissues in various ratios  Epidermal tissue (skin) -  Multiple cell layers – epidermis, dermis, hypodermis  Multiple tissue types – epitheial, connective, muscular, nervous  Multiple functions – protection, metabolism, temperature regulation, water proofing, blood storage, insulation, excretion, sensory organ
  • 35. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings UN 3-1 - Overview
  • 36. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Integument System Functions 1. Protection 2. Insulation 3. Water proofing 4. Temperature regulation 5. Excretion 6. Cutaneous Sensory organ 7. Metabolism 8. Blood reservoir