Bill Faloon presents at the April 25th life extension webinar, giving an update about the status of age-reversal research in 2020.

1. Age Reversal Update
April 25 2020
Coalition for Radical Life Extension
Webinar
William Faloon
These slides available for review at: www.age-reversal.net

2. age-reversal.net
This entire presentation available at:

3. Unparalleled Track Record
of Biomedical Innovation
Established 1977

5. Record Attendance at RAADfest Generates Ancillary Benefits

6. http://med.miami.edu/news/interdisciplinary-stem-cell-institute-at-the-university-of-miami-receives-2
Interdisciplinary Stem Cell Institute
at the University of Miami Receives $25 Million Donation
“The Interdisciplinary Stem Cell Institute at the
University of Miami Miller School of Medicine
has received a $25 million donation from
the Soffer Family Foundation.”
“The funding will allow the institute to continue
its groundbreaking stem cell research… in
fields of cardiology, sports medicine, and
aging-related conditions.”
October 8th 2019

7. NIH Funds $23 Million
Dog Study that includes
RAPAMYCIN Daniel Promislow
principal investigator of the Dog Aging Project
“Old dogs, new tricks: 10,000
pets needed for aging study”
https://www.nbcnews.com/health/health-news/old-dogs-new-tricks-10-000-pets-needed-science-n1082151

8. The Growing Rebellion
https://www.newscientist.com/issue/3257/
Against Aging and Death
November 20, 2019
“Why the line between life
and death is now more
blurred than ever…life's end
is less final than we thought.”

9. Confidential Cures Summit
Palm Beach, Florida
December 8-9, 2019
William Faloon, Liz Parrish, Al Sears
Jesse Ventura, Bill Andrews (others)
+
Reaching the Critical Mass
=
Age Reversal Conference
December 2019

10. Newt Gingrich: Can aging be reversed?
Incredible new research may let us
grow younger instead of older
By Newt Gingrich / Fox News Opinion January 5, 2020
January 5, 2020

11. https://medicine.wustl.edu/news/families-with-long-healthy-life-spans-focus-of-68-million-grant/
Washington University School of
Medicine in St. Louis has received
a $68 million NIH grant to
investigate and discover what
contributes to extreme longevity.
Many of these families have
unusual concentrations of people
living to at least age 100.
December 5th 2019
NIH provide $68 million grant to study long lived families

12. Premiere Issue Jan. 2020
theimmortalistsclub.com

13. “…a cluster of scientists, technologists and
investors are aiming higher…
”As recently as five years ago,” Mr. Walter writes,
“the great pashas at [the National Institutes of
Health] . . . looked upon aging research as largely
crackpot.”
Published by:
In the vernacular of Silicon Valley, where
many of them are based, their goal is nothing
less than disrupting death….”

14. Author of Immortality, Inc. (Chip Walter)
Speaker at this Year’s RAADfest
Chip Walter

15. The Ultra-rich Are Investing In Companies
Trying To Reverse Aging. Is It Going To Work?
In 2013, Google formed aging research company
Calico. Oracle co-founder Larry Ellison has donated
hundreds of millions of dollars to aging research, The
New Yorker reported.
There are a slew of other companies tackling aging,
including BioAge, BioViva, The Longevity Fund, AgeX
and the Methuselah Foundation.
“Whenever you meet a fundamental human need,
there’s a market,” said Michael West, a gerontologist
and CEO of AgeX Therapeutics. “And in this case, the
market for age-related disease and aging is a trillion
dollar market.”
https://www.cnbc.com/2020/02/19/the-ultra-rich-are-investing-in-companies-trying-to-reverse-aging.html

16. Nov 29. 2015

17. Metformin Anti-aging Trial Gets Green-light
https://www.longevity.technology/worlds-first-anti-aging-trial-gets-green-light/
Sept 4, 2019
2015 - FDA approves first anti-aging study of a drug.
2019 - Metformin study receives $75 million funding.
($40 million from anonymous donor)

18. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019
https://doi.org/10.1073/pnas.1913212116
Rapamycin Lithium Trametinib+ +
Fruit Fly Lifespan Extension by 48%
=
“…a combination of drugs already approved for
human use is a viable strategy to maximize animal
longevity…”
This recent study supports the stairstep approach advocated to enable us to live significantly longer
Oct 15. 2019

19. Fruit flies received drugs separately and/or in combination.
 Each drug individually extended lifespan by 11%
 Pairing two drugs extended lifespan roughly 30%
 Three drugs combined extended lifespan by 48%
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana
Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network
maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
Combination Treatments are Essential
Oct 15. 2019

21. New study shows
maximum natural
lifespan of bowhead
whales is 268 years.
DNA Methylation Test Reveals
Bowhead Whales Longevity
https://cosmosmagazine.com/biology/life-clock-ticking

22. Sequencing the genome of the bowhead whale was
done to identify candidate genes to explain their long
lifespan and resistance to diseases.
This project helped elucidate genes conferring longevity
and disease resistance that may to improve human health.
Why This Research Was Funded?
This project was supported by grants from the Life Extension Foundation and the Methuselah Foundation.

23. DEC. 8, 2019
“A Harvard geneticist's goal: to
protect humans from viruses,
genetic diseases, and aging”
George Church's lab at Harvard Medical School is working
to make humans immune to all viruses, eliminate genetic
diseases and reverse the aging process…

24. December 2, 2015
George Church, Ph.D.
A Cure for Aging by Year 2030?
https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/

25. April 25, 2018
https://www.newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body/
“George Church: The maverick
geneticist now wants to reverse aging”
“He stirred controversy with his plans to bring back the
woolly mammoth. But first he's working on editing sperm
– and trying out his aging reversal techniques on dogs.”

27. https://www.nextbigfuture.com/2019/01/delivery-of-45-age-reversing-gene-therapies-at-once-is-under-peer-review.html
Delivery of 45 Age Reversing Gene
Therapies at Once is Under Peer Review
Jan 12, 2019
Dr. Church expects to get this
treatment to people around 2025.
George Church delivers 45 unique
gene therapies aimed at multiple
age-related disorders in mice.
This combined gene treatment
effective against obesity, diabetes,
osteoarthritis, cardiac damage &
kidney disease.

28. 100 years from now,
“physicians will have the
capacity to keep people alive
indefinitely,” says Dr. Michael
Rose, director and professor in
the Department of Ecology and
Evolutionary Biology at the
University of California, Irvine.
MICHAEL ROSE: DEPARTMENT OF ECOLOGY
AND EVOLUTIONARY BIOLOGY, UC, IRVINE
January 2020
EMBRACING THE POWER OF
EVOLUTION TO PUT A STOP AGING
http://www.llamapodcast.com/michael-rose/

29. https://www.nejm.org/doi/full/10.1056/NEJMra1905136
Effects of Intermittent Fasting on Health, Aging, and Disease
Dec. 26, 2019
 Obesity
 Dyslipidemia
 Hypertension
 Inflammation
 Insulin resistance
In humans intermittent-fasting interventions ameliorate:
One study found
57% decrease in
fasting insulin levels

30. Scientists have identified synergistic cellular pathways for
longevity that amplify lifespan fivefold in C. elegans, a
nematode worm used as a model in aging research.
“The increase in lifespan would be the
equivalent of a human living for 400 or 500
years, according to one of the scientists.”
Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di
Chen. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019;
28 (4): 1050 DOI: 10.1016/j.celrep.2019.06.078
“Pathways that extend lifespan
By 500 percent identified” Jan 8, 2020

31. “In fact, the two pathways which the team
manipulated—known as the insulin signaling and
TOR pathways—are also found in people.
This means that the latest results could
have implications for the development of
new anti-aging therapies.”
SCIENTISTS EXTENDED THE LIFESPAN
OF THESE ANIMALS BY 500 PERCENT
Jan 9, 2020
https://www.newsweek.com/scientists-extend-lifespan-animals-500-percent-1481241

32. Details of 500% Lifespan Extension
https://www.buckinstitute.org/news/more-details-on-500-lifespan-extension-highlight-bucks-role-in-moving-science-forward/
Jan. 21, 2020
Buckco-authorsreportnearly500%lifespanincreaseinthenematodeC.elegans
These particular pathways are shared with mammals, so this work has potential
relevance for human biology. Hence, the study garnered a lot of media buzz.
In humans this is the equivalent of living over 400 years!
One mutationinthedaf-2gene(partofinsulinsignalingpathway)andanother
relatedtothemTORpathway(thatregulatescellgrowth)createdasynergistic
effectthatledtoalifespanincreaseof454%.
(daf-2 stands for abnormal DAuer Formation. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms.)

33. Aging Cell. 2020 Mar; 19(3): e13110. Published online 2020 Feb 3. doi: 10.1111/acel.13110
Young-Donor Hematopoietic Stem Cell
Transplantation Extends Life Span in Mice
Further, young‐donor cells maintained
youthful features while still under the
influence of the aged bone marrow stroma.
Aged recipient mice underwent a mobilization‐based
hematopoietic stem cell transplantation procedure
followed by infusion of young‐donor stem cells.
“Young‐donor stem cells reverse age‐associated
features and increase the health and longevity
of aged recipients following aged hematopoietic
stem cell replacement.”

34. https://www.the-scientist.com/features/can-destroying-senescent-cells-treat-age-related-disease--67136
Can Destroying Senescent
Cells Treat Age-Related Disease?
A handful ofclinical trials are underway to find out whether
drugs that target senescent cells can slow the ravages of old age.
March 1st, 2020
Several biotechs have sprouted in recent years to identify
compounds that target senescent cells and put such
“senolytic” drugs to the test in humans—efforts that are
supported by considerable funding influxes from both
federal sources like the NIH and private sources such as that
of Peter Theil and Jeff Bezos.
“Getting rid of senescent cells is enough to effectively rejuvenate
ananimal—thattellsyouthey’reareallyimportantdriverofaging.”

35. Scientists restore mobility + touch sensation in stroke-afflicted rats by reprogramming
human skin cells to become nerve cells, which were then transplanted into rats’ brains.
April 6, 2020
Researchers Repair Stroke-Damaged Mice Brains Using Human Cells
“It is remarkable to find that it is actually possible to repair a stroke
damaged brain and recreate nerve connections that have been lost.”
- Olle Lindvall, Senior Professor, Division of Neurology, Lund University
Transplanted nerve cells (transplant up to the right), which were
produced from human skin cells, send their nerve fibers to the cerebral
cortex on the opposite side of the brain in a stroke-afflicted rat.
“Six months after the transplantation,
we could see how the new cells had
repaired the damage that a stroke had
caused in the rats’ brains.”
- Prof Zaal Kokaia, Div of Neurology, Lund University
https://www.lunduniversity.lu.se/article/researchers-successfully-repair-stroke-damaged-rat-brains

37. “At the end of the 19th century, life expectancy in
the United States was 48 years for whites and
34 for blacks.”
“Mr. Levinson founded Calico, a company devoted
to drug development and extending the human life
span. Google kicked in $750 million, as did the
pharmaceutical company AbbVie.”
While “Immortality, Inc.” is focused on aging and
the efforts to defy it, the book is also a gripping
chronicle of private-sector experimentation and
ingenuity in the face of inertia in Washington.
Cracking the Aging Process and Curing Death!
www.amazon.com/Immortality-Inc-Renegade-Scientists-Cheating-ebook/dp/B07CWG8WXG

38. Joseph Myron Segel, founder of
the home-shopping behemoth
QVC Network.
Cause of death was congestive
heart failure at the age of 88.Joseph Segel (1931-2019)
Expiration date: Dec. 21, 2019
Net worth > $20 billion www.wharton.upenn.edu/wp-content/uploads/125anniversaryissue/segel.html
Who missed the longevity boat?

39. We Don’t Have Time for
Delayed Age Reversal

40. Vitality in Aging Research
Group believes that targeting
only one pathway of aging in
humans will not produce a
meaningful change in
healthspan or longevity.
Today’s Dilemma

41. -THE SOLUTION-

42. itality in Aging believes a
cocktail of CR mimetics
combined with several non-CR
mimetic treatments will have a
significant impact on health and
age-related diseases as
measured by markers of
biological age.

43. Age Reversal
Interventions
Autophagy Resolve inflammation
Remove
senescent cells
Restore
youthful methylation
Lengthen
telomeres
AMPK/
mTOR
Sirtuins -
NAD+
Exosomes

44. Two Age Reversal Studies:
1) Vitality in Aging Longitudinal Study
2) Vitality in Aging Interventions Trial

45. Long Term Funding Sources Will Be Needed
Human Age Reversal Project
Bill Faloon
Donations of Physicians’ Time
Funding Need: $530,000
Donations Received to Date: $682,000
Vitality in Aging Interventions Trial Financial Update
SOURCES OF FUNDING:

46. Vitality in Aging Longitudinal Study
(Sign up at: VitalityInAging.org/

47. Since launching at RAADfest 2019 over
400 individuals have enrolled to participate.
Upwards of 1000 study subjects are expected
to enroll in the coming 12-15 months.
Study subjects will be followed for at
least 10 years if funding levels continue.
Vitality in Aging has gathered
important new information about
measuring aging processes and
how they may be circumvented.

48. Predictive and diagnostic values of
established and novel aging biomarkers.
A better understanding of biological
agingandwhatcanbedonetoreverseit.

49. Gathering Information from Study Subjects is Critical
to Understanding Aging and Successfully Intervening!
Blood biomarkers – through the Age Management Panel
Medical history (pre-existing conditions, family history, etc.)
Body composition
Genomic information
Lifestyle factors, including dietary choices
DNA methylation patterns
Skeletal muscle fitness
Immune health
Cognitive function
Sexual health
Novel tests to be added as they are validated and available

50. 1) Enlarging, restructuring, and improving electronic
data capturing capabilities.
To Expand Data Capturing and Enhance Remote
Participation the Vitality In Aging Research Group is:
2) Enhancing the electronic informed consents,
health questionnaires, surveys, and reminders.
3) Developing remote and virtual testing when possible.

51. Vitality inAging (VIA) Longitudinal Study participation consists of:
1) Completion of the Age Management Blood Test Panel on an annual basis.
The price of the Age Management Panel has changed to $495 and includes the
Omega-3 Index kit. We will be asking participants to complete this blood test
every twelve months.
2) Completion of annual surveys that will be available online. After the initial
survey, we will ask you to update any health or demographic data every year.
3) Additional surveys may be sent out that focus on specific topics, such as diet,
skin health, and various lifestyle choices. These additional surveys will be
optional.
To enroll in VIA Longitudinal Study: VitalityInAging.org/

52. How to do a $50 million/5-Year
Clinical trial in 1 Year for $530,000
(Many of us can't wait 5 years and we don't have $50 million)
Human Age Reversal Research
Rigorous Tightly Controlled

53. Participants
selected from
Longitudinal Study
Vitality in Aging Interventions Trial
Objective: Evaluate a combination of compounds that
individually have been shown to increase healthspan
and/or lifespan in model organisms.

55. Long Term Funding Sources Will Be Needed
Human Age Reversal Project
Bill Faloon
Donations of Physicians’ Time
Funding Need: $530,000
Donations Received to Date: $682,000
Vitality in Aging Interventions Trial Financial Update
SOURCES OF FUNDING:

56. Human Age Reversal Project
Goal: Induce meaningful and statistically significant
age-reversal within a 12-month period.
Vitality in Aging
Interventions Trial
$682,000 in donations remain in
interest-bearing broker account to
exclusively fund the:

57. Step #1: VIA Longitudinal Study
Step #2: VIA Interventions Trial
You pay (at deep-discounted prices) for
lab tests and interventions.
(Everyone should enroll in this study)
Human Age Reversal Project pays
for lab tests and medical interventions.
(30-50 people selected for this study)

58. More tax-deductible donations needed to expand research
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate

59. Step 1: Join the
Vitality in Aging Longitudinal Study
(Sign up at: VitalityInAging.org/

60. Participants selected from Longitudinal Study
Vitality in Aging Interventions Trial
Step 2:

61. Age Reversal
Interventions
Autophagy Resolve inflammation
Remove
senescent cells
Restore
youthful methylation
Lengthen
telomeres
AMPK/
mTOR
Sirtuins -
NAD+
Exosomes

62. Clayton Williams, a colorful Texas oilman
and philanthropist.
Williams died at his home in Midland after
struggling with pneumonia. He was 88.
Who missed the longevity boat?
Clayton Williams (1931-2020)
Expiration date: Feb. 14, 2020
Net worth > $1.3 billion https://www.bloomberg.com/news/articles/2020-02-16/oilman-former-texas-governor-candidate-williams-dies-at-88

63. Multi-billionaire real estate
developer dies of Covid-19
complications at age 78.
One of Donald Trump’s closest
friends…donated over $400,000
to Trump campaign.
Who missed the longevity boat?
Stanley Chera (1942-2020)
Expiration date: Apr. 10, 2020
Net worth > $4.3 billion https://nypost.com/2020/04/13/real-estate-mogul-stanley-chera-dead-at-78-from-coronavirus/

64. At age 99, Justin died before validated age
reversal therapies became available.
Who missed the longevity boat?
JUSTIN RICE
(1918 -2017)
Expiration date: Nov. 3, 2017
Net worth > $?
Pioneering member of Life Extension®.
Justin Rice was the CEO of Coeur d’Alene
Mines Corporation, a NYSE company.
Under Justin’s leadership the company
became world’s largest silver producer,

65. Age Reversal Update
April 25 2020
RAADfest
Zoom Video Conference
William Faloon
These slides available for review at: www.age-reversal.net

66. age-reversal.net
This entire presentation available at:

67. Unparalleled Track Record
of Biomedical Innovation
Established 1977