Bill Faloon at RAADfest 2020

2 0 2 0
1.What’sCausingOurAlumnitoDie?
2. SurveyofSelf-Experimenters
3. Vitality in Aging Human Studies
4. Age Reversal Updates
5. New Clinical Trials Facility & Lab
Betterhumans
AntiAging Clinical Trials
Needless Death
Topics to be Presented by Bill Faloon

Established 1977
to Needlessly Die”
“No One is Allowed

Risk of Delay: Chronic Diseases May Create Side Effects

https://www.businessinsider.com/coronavirus-death-age-older-people-higher-risk-2020-2
COVID Deaths
Spike Higher
with Age

Heart Disease Death Rate by Age

Death Probability Per Year by Age

Aging Makes Us Ducks in a Shooting Gallery

Will COVID-19 Instill Scientific Rationality?
How Most People Confront Aging

New Findings
after last year’s
RAADfest
In chronological order…

Interdisciplinary Stem Cell Institute
at the University of Miami Receives $25 Million Donation
“The Interdisciplinary Stem Cell Institute at the
University of Miami Miller School of Medicine
has received a $25 million donation from
the Soffer Family Foundation.”
“The funding will allow the institute to continue
its groundbreaking stem cell research… in
fields of cardiology, sports medicine, and
aging-related conditions.”
October 8th 2019

Metformin Anti-Aging Trial Gets Green-Light
https://www.longevity.technology/worlds-first-anti-aging-trial-gets-green-light/
Sept 4, 2019
2015-FDAapprovesfirstanti-agingstudyofadrug.
2019-Metforminstudyreceives$75millionfunding.
($40 million from anonymous donor)

PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019
https://doi.org/10.1073/pnas.1913212116
Rapamycin Lithium Trametinib+ +
Fruit Fly Lifespan Extension by 48%
=
“…a combination of drugs already approved for
human use is a viable strategy to maximize animal
longevity…”
This study supports the stairstep approach advocated to enable us to live significantly longer
Oct 15. 2019

Fruit flies received drugs separately and/or in combination.
 Each drug individually extended lifespan by 11%
 Pairing two drugs extended lifespan roughly 30%
 Three drugs combined extended lifespan by 48%
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana
Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network
maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
Combination Treatments Are Essential
Oct 15. 2019

NIH Funds $23 Million
Dog Study that includes
RAPAMYCIN Daniel Promislow
principal investigator of the Dog Aging Project
“Old dogs, new tricks: 10,000
pets needed for aging study”
https://www.nbcnews.com/health/health-news/old-dogs-new-tricks-10-000-pets-needed-science-n1082151

The Growing Rebellion
https://www.newscientist.com/issue/3257/
Against Aging and Death
November 20, 2019
“Why the line between life
and death is now more
blurred than ever…life's end
is less final than we thought.”

December 5th 2019
NIH provide $68 million grant to study long-lived families
National Institutes of Health
grants $68 million to discover
what enables extreme longevity.
Many of these families have
unusual concentrations of people
living to at least age 100.
https://medicine.wustl.edu/news/families-with-long-healthy-life-spans-focus-of-68-million-grant/

Confidential Cures Summit
Palm Beach, Florida
December 8-9, 2019
William Faloon, Liz Parrish, Al Sears
Jesse Ventura, Bill Andrews (others)
+
=
Age Reversal Conference
DECEMBER 2019
Reaching the Critical Mass

Can aging be reversed?
Incredible new research may let us grow
younger instead of older
By Newt Gingrich / Fox News Opinion January 5, 2020
January 5, 2020

December 2, 2015
George Church, Ph.D.
A Cure for Aging by Year 2030?
https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process

newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body
“George Church: The maverick
geneticist now wants to reverse aging”

Results from single dose combination gene therapy:
Noah Davidsohn, Matthew Pezone, Andyna Vernet, Amanda Graveline, Daniel Oliver, Shimyn Slomovic, Sukanya
Punthambaker, Xiaoming Sun, Ronglih Liao, Joseph V. Bonventre, and View ORCID Profile George M. Church
PNAS November 19, 2019 116 (47) 23505-23511; https://doi.org/10.1073/pnas.1910073116
November 19, 2019
1)58%increasedfunctionafterheartfailure
2)38%reductioninvasculardiseasemarker
3) 75% reduction in kidney atrophy
4)Complete reversal ofobesity &diabetes

DEC. 8, 2019
“A Harvard geneticist's goal: to
protect humans from viruses,
genetic diseases, and aging”
George Church's lab at Harvard Medical School is working
to make humans immune to all viruses, eliminate genetic
diseases and reverse the aging process…

https://www.nejm.org/doi/full/10.1056/NEJMra1905136
EffectsofIntermittentFastingonHealth,Aging,andDisease
Dec. 26, 2019
Suppresses inflammation
Reduces obesity and type II diabetes
Protects against cardiovascular disease
Lowers risk of neurodegenerative disorders
Reduces cancer incidence
Animal models show consistent robust benefits of intermittent fasting:

Average life span of rats
increased by up to 80%
when maintained on
alternate-day feeding started
when they are young adults.
Effects of IntermittentFasting on Aging
Dec. 26, 2019

Effects of Intermittent Fasting on Health, Aging, and Disease
Dec. 26, 2019
 Obesity
 Dyslipidemia
 Hypertension
 Inflammation
 Insulin resistance
In humans intermittent-fasting interventions ameliorate:
One study found a
57% decrease in
fasting insulin levels

“Evidence is accumulating that eating in a 6-hour
period and fasting for 18 hours can trigger a
metabolic switch from glucose-based to ketone-
based energy, with increased stress resistance,
increased longevity, and a decreased incidence of
diseases, including cancer and obesity.”
- Rafael de Cabo, Ph.D., and Mark P. Mattson, Ph.D.
Effects of Intermittent Fasting on Health, Aging, and Disease
Dec. 26, 2019

EffectsofIntermittentFastingonHealth,Aging,andDisease
Dec. 26, 2019
Abdominal fat
Blood pressure
Stress resistance
Glucose regulation
Human benefits of intermittent fasting:
Heart rate
Endurance
Cognition
Inflammation
IMPROVEMENTS IN ALL THESE KEY MARKERS AND MORE

Cellular Effects of Intermittent Fasting
December 26, 2019
Stimulates autophagy
Inhibits mTOR
Removes cellular junk
Boosts molecule recycling

EffectsofIntermittentFastingonHealthandAging

Scientists have identified synergistic cellular pathways for
longevity that amplify lifespan fivefold in C. elegans, a
nematode worm used as a model in aging research.
“The increase in lifespan would be the
equivalent of a human living for 400 or 500
years, according to one of the scientists.”
Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di
Chen. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019;
28 (4): 1050 DOI: 10.1016/j.celrep.2019.06.078
“Pathways that extend lifespan
By 500 percent identified” Jan 8, 2020

“In fact, the two pathways which the team
manipulated—known as the insulin signaling
and TOR pathways—are also found in people.
SCIENTISTS EXTENDED THE LIFESPAN
OF THESE ANIMALS BY 500 PERCENT
Jan 9, 2020
https://www.newsweek.com/scientists-extend-lifespan-animals-500-percent-1481241
This means that the latest results could
have implications for the development
of new anti-aging therapies.”

Details of 500% Lifespan Extension
https://www.buckinstitute.org/news/more-details-on-500-lifespan-extension-highlight-bucks-role-in-moving-science-forward/
Jan. 21, 2020
Buckco-authorsreportnearly500%lifespanincreaseinthenematodeC.elegans
These particular pathways are shared with mammals, so this work has potential
relevance for human biology. Hence, the study generated a lot of media buzz.
In humans this is the equivalent of living over 400 years!
One mutationinthedaf-2gene(partofinsulinsignalingpathway)andanother
relatedtothemTORpathway(thatregulatescellgrowth)createdasynergistic
effectthatledtoalifespanincreaseof454%.
(daf-2 stands for abnormal DAuer Formation. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms.)

Premiere Issue Jan. 2020
theimmortalistsclub.com

“As recently as five years
ago,” Mr. Walter writes, “the
great pashas at [the National
Institutes of Health] . . .
looked upon aging research
as largely crackpot.”
Published by:

100 years from now,
“physicians will have the
capacity to keep people alive
indefinitely” says Dr. Michael
Rose at the University of
California, Irvine.
MICHAEL ROSE, Ph.D., DIRECTOR AND
PROFESSOR OF DEPARTMENT OF ECOLOGY
AND EVOLUTIONARY BIOLOGY, UC, IRVINE
January 2020
EMBRACING THE POWER OF
EVOLUTION TO PUT A STOP AGING
http://www.llamapodcast.com/michael-rose/

The Ultra-Rich Are Investing in Companies
Trying To Reverse Aging. Is It Going To Work?
In 2013, Google formed aging research company
Calico. Oracle co-founder Larry Ellison has donated
hundreds of millions of dollars to aging research, The
New Yorker reported.
There are a slew of other companies tackling aging,
including BioAge, BioViva, The Longevity Fund, AgeX
and the Methuselah Foundation.
“Whenever you meet a fundamental human need,
there’s a market,” said Michael West, a gerontologist
and CEO of AgeX Therapeutics. “And in this case, the
market for age-related disease and aging is a trillion
dollar market.”
https://www.cnbc.com/2020/02/19/the-ultra-rich-are-investing-in-companies-trying-to-reverse-aging.html

https://phys.org/news/2020-03-supercentenarian-derived-stem-cells.html
Blood cells from 114-year-old
woman reprogrammed into
induced pluripotent stem cells
(iPSCs).
March 20th, 2020
This advance may enable
clinical studies seeking to
emulate the healthy longevity
of supercentenarians.

https://www.sciencedirect.com/science/article/pii/S0006291X20303661
Feb 27th, 2020
Theoretically, a future version of this
therapy, where cell samples are taken in
mass to be reverted to age zero stem
cells, clonally expanded, and then
reintroduced clinically would allow for the
restoration of vitality in one’s cell line.
Transcriptomes of many renewed cells
no-different from young controls.

Can We Reprogram Aging In The Body?
Cell Age Reversal In Vitro Age Reversal In Vivo
iTR
Requires “Partial Reprogramming” or “induced Tissue Regeneration” (iTR)

Can we Reprogram Aging in the Body?
ReCyte1 EC Cell Line Exosomes
Load with
Telomerase mRNA
In Vivo Age Reversal
Life Extension® funded $2 million dollars to help create this ReCyte1 EC Cell Line
Can We Reprogram Aging In The Body?
The Future of Age Reversal?

Dr. Mike West’s Comments about this Research
The supercentenarian study showed what we already expected, which is that
the aging of cells (of any age), is completely reprogrammable.
Our goal is to make ReCyte-1 a source of reprogramming exosomes.
We would collect the exosomes carrying reprogramming RNA, and release
them in the body, to transiently express telomerase to restore cell lifespan,
and reprogramming factors to reverse the developmental clock.
The goal is to induce the natural regenerative potential our tissues have early
in life, that is, to induce tissue regeneration (iTR).
Email from Mike West, Ph.D. to Bill Faloon on August 12, 2020

318% increased value in five years
September 7, 2020
Remaining stake in young plasma
group Alkahest sells for $146 million
 Alkahest develops treatments forage-related diseases.
 Therapies target the aging plasma proteome.
 Company has four candidates in six phase-2 clinical trials.
 Founded byStanfordUniversityscientists who demonstrated
youngbloodfactors restoremental capabilities in old animals.
https://www.pharmaceutical-business-review.com/news/grifols-alkahest-full-ownership/
“Now we see a wealth of plasma-derived and non-plasma therapeutic candidates identified by
Alkahest that can significantly support the unmet needs of many diseases associated with aging.”

What is Epigenetic Age?
“Epigenetics” refers to external modifications that occur in gene
expression as a result of what we do to our bodies, as opposed to
the genetic code we are born with.
Ingesting overcooked food or inhaling
cigarette smoke causes deleterious
epigenetic changes to DNA.
Vitamin D and omega-3s induce
beneficial epigenetic effects.
Examples:

DNA methylation controls the
transcription (activation) of genes.
Without proper DNAmethylation,
beneficial genes are deactivated while
harmful genes can be over-expressed.
DNA Methylation measures Epigenetic Age
Young plasma treatment more than halved epigenetic ages.
This is the principal of what is called
“epigenetic aging.”

April 21st, 2020
Horvath, S., Singh, K., Raj, K., Khairnar, S., Sanghavi, A., Shrivastava, A., ... & Lehmann, M. (2020).
Reversing age: dual species measurement of epigenetic age with a single clock. bioRxiv.
Young plasma treatment more
than halved the epigenetic ages
of blood, heart and liver tissues.
Epigenetic clock measures
indicate systemic rejuvenation.

https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full
April 21st, 2020
Cellular senescence
reduced in vital organs.
Young Plasma fraction
improvesorganfunctionand
measures of cognition.
The effect of plasma
fraction treatment on
cellular senescence:
After a 155-day
treatment period, the
brains of young plasma
treated old rats and
young rats were stained
for senescence-
associated “beta-
galactosidase”, whose
activity on the substrate
turns senescent cells
blue in color.

Within 10 days of
young plasma fraction
treatment the physical
capacities of old rats are
indistinguishable from
that of the young rats.
Horvath, S., Singh, K., Raj, K., Khairnar, S., Sanghavi, A., Shrivastava, A., ... & Lehmann, M. (2020).
Reversing age: dual species measurement of epigenetic age with a single clock. bioRxiv.
Grip Strength Analysis
April 21, 2020

Rejuvenation of Three Germ Layer
TissuesbyRemovingOldBloodPlasma
May30,2020
https://www.aging-us.com/article/103418/text
Result likely due to the removal of
extra-cellular “junk” in old plasma.
Removal of 50% of an aged mouse’s
plasma and replacing it with saline
containing 5% albumin resulted in
enhanced muscle repair, reduced
liver fat and fibrosis, and increased
neurogenesis.

July 10th, 2020
Blood Factors Transfer Beneficial Effects of Exercise
on Neurogenesis and Cognition to the Aged Brain
Researchers transfused plasma from old mice
who were allowed to exercise for 6 weeks to
other old mice who were not allowed.
Rodents who received the plasma from the
active mice grew roughly twice as many new
neurons in the hippocampus as controls.
https://www.sciencemag.org/news/2020/07/protein-blood-exercising-mice-rejuvenates-brains-couch-potato-mice
Couch potato mice receiving this blood eight
times over 3 weeks did nearly as well onlearning
and memory tests as the exercising mice.

“...aged mice that received plasma from
middle-age or old mice that exercised
showed beneficial effects in their brains
without hitting the treadmill.”
https://science.sciencemag.org/content/369/6500/167
An enzyme generated in livers
of exercising mice demonstrate
similar brain restoring effects.
Blood factors transfer beneficial
effects of exercise to the aged brain

https://www.magentatx.com/revolutionizing-medicine/programs/
Immune reset throughtransplant: a2-step process
Step 1: Remove the disease-causing cells
Step 2: Replace with healthy cells to rebuild
immune system.
Three new agents — CD45-ADC, CD117-ADC, and C300 —
precisely remove only disease-causing cells in the body, without
the need for chemotherapy or radiation, and make room for
incoming healthy cells to rebuild a functioning immune system.
Rebuild Bone Marrow to Restore Youthful Immunity

RestoringYouthfulImmunitybyRebuildingBoneMarrow
https://www.magentatx.com/revolutionizing-medicine/programs/

Oct.14,2017
Cardiac and Systemic Rejuvenation after Cardiosphere
Derived (Progenitor) Cell Therapy in Senescent Rats
Aging is characterized by progressive shortening of
telomeres and is associated with heart dysfunction
and reduced regenerative capacity.
CDCs also work indirectly to reverse aging systemically…
https://academic.oup.com/eurheartj/article/38/39/2957/4080843
1) Cardiomyocytes
2) Endothelial cells
3) Smooth muscle cells
Cardiosphere-derivedcells(CDCs)are cardiacprogenitorcells
thatcandifferentiateintothethreemajorheartcelltypes:

October14,2017
Effects of Cardiosphere-derived Cells in Old Hearts
Young rat CDCs transplanted into hearts of old rats resulted in:
Restored young gene expression
pattern in heart cells of old animals
(in 85.5% of genes).
Telomeres in heart cells were
longer with hypertrophy and
myocardial fibrosis reduced.
Improved diastolic dysfunction
and lowered a heart failure
marker (natriuretic peptide).

October14,2017
In Vivo Effects of Cardiosphere-derived Cells
Young CDCs transplanted into hearts of old rats resulted in:
Exercise capacity increased 20%
Body weight decreased 30%
Hair regrowth after shaving more robust
Inflammatory markers reduced 25%-60%
Senescent cell population reduced

Bridging the Longevity Gap
Urgent Need to Access Age-Reversal Interventions

New Clinical Trials Center in Florida

Anti-Aging Clinical Trials
Building 200, Suite 205
13940 US Hwy 441
The Villages, FL 32159
Betterhumans.org

Betterhumans Clinic: The Villages, FL
Doctor’s Office8-Person Waiting Room

Main Patient
Exam Room 2nd Patient Exam Room

GE Lunar Prodigy Advance Bone Densitometer
 Visceral fat
 Bone density
 Muscle mass
Visceral fat
Bone density
Muscle mass
Measures:

Blood
Sample
Prep
Room

Betterhumans Lab RNA & DNA Sequencing Room
 DNA methylation
(Horvath Clocks)
 Whole-Transcriptome
gene expression.
 Measuring circulating
viruses.
 Measuring circulating
bacteria.
In-house DNA and
RNA sequencing:

Mass Spectrometry Room Multi-purpose Sequencing Room

Betterhumans laboratory measures:
Horvath Clocks (DNA methylation/Epigenetic
Aging), using Illumina iScan sequencers.
Expression of 20,000 genes using Ion Torrent
whole-Transcriptome RNA sequencing.
Pro- and Anti-inflammatorycytokine levelsusing
immunofluorescence assay(also measures some
SASPS – senescentcell secretoryphenotypes).
NAD+ measurements by mass spectrometer
(40 times more sensitive than a few years ago).

Highspeed Centrifuge & Cell-Culture Incubators

“Biologicals” cGMP Processing Hood

Betterhumans Lab: Gainesville, FL
 Maintaining cell lines
 Creating iPS (stem) cells
 Partial-reprogramming
of cells
 Isolating mitochondria
 Isolating exosomes
Cleanroom where “biologicals”
are created and stored.

Anti-Aging Clinical Trials to assess safety/efficacy of:
1) Oncea month "old factors"plasma dilution.
2) Compare effectiveness of senolytic
compounds on senescent cell load.
3) Long-termeffectsof intermittentrapamycin.
4) Replenishment of NAD+ in elderly people.
5) Intermittent "exosomes" injections.
6) Other interventionsto slow or reverseaging.

Betterhumans “Biologicals”
Epigenetic
Reprogramming
Stem Cells
Mitochondria
Exosomes

1) Real-time data
as opposed to
months/years later
2) 125,000 senior
citizens within
35-mile area
3) Estimated opening
date: October 2020

New Clinical Trials Center in Florida
Betterhumans.org

Senolytics Update
October 3rd 2020

Senescent cells accumulate with normal aging and:
Removing Senescent Cells Confers Healthy Longevity

Senolytics are compounds
that selectively destroy
senescent cells.

 Improvefrailtysymptoms(gait,gripstrength)
 Improve kidney/liver pathologic age scores
 Improve cardiac/arterial function
 Decrease osteoporosis
 Increase exercise endurance
 Enhance coat color appearance
 Reduce tremors and urinary incontinence
 Extend healthy lifespan
Results of Quercetin + Dasatinib in Rodents
Zhu, Yi, Tamara Tchkonia, Tamar Pirtskhalava, Adam C. Gower, Husheng Ding, Nino Giorgadze, Allyson K. Palmer et
al. "The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs." Aging cell 14, no. 4 (2015): 644-658.

Dr. Alan Green at his practice in Little Neck, NY
now has 500+ patients using rapamycin with
100+ patient adding dasatinib, fisetin and
quercetin .
Dr. Green’s Anti-Aging Cocktail
1) Rapamycin
2) Dasatinib
3) Fisetin
4) Quercetin
Now in Clinical Use:
https://senolyticstreatment.com/

Dr. Alan Green’s Senolytic Protocol
 Dasatinib: 100 mg a day for 3 days
 Quercetin: 1000 mg a day for 3 days
 Fisetin 1500 mg day for 3 days
https://senolyticstreatment.com/
These are maximum doses. Patients determine sensitivity with smaller doses.
For diseases like Alzheimer's, cardiomyopathy, pulmonary fibrosis, emphysema,
fatty liver, chronic kidney disease, metabolic syndrome, obesity, frailty:
1-2 of these senolytic treatments a month
For lifespan and healthspan: 4 treatments a year (3-month) interval

Karin, Omer, Amit Agrawal, Ziv Porat, Valery Krizhanovsky, and Uri Alon. "Senescent cell turnover slows with
age providing an explanation for the Gompertz law." Nature communications 10, no. 1 (2019): 1-9.
Senescent Cells Snowball
• Senescent cell production rate increases with age
due to accumulation of mutations, telomere
damage, other factors triggering cell senescence.
• Senescent cells catalyze their own production by
paracrine and bystander effects.
• Senescent cell removal decreases with age due to
decline in immune surveillance functions,
• Senescent cells reduce their own removal rate…”
December 2, 2019

The Burden is Eventually Unbearable
Senescent cell’s turnover in 5 days in 3-month-old
mice but take 25 days in 22-month-old mice. This
model predicts a vicious cycle where senescent
cells accumulate faster and are degraded slower.
"Our results suggest that treatments that
remove senescent cells can have a double
benefit: an immediate benefit from a
reduced senescent cell load, and a longer-term
benefit from increased senescent cell removal."
At the point of 30% senescent cell load animals
often appear to reach a tipping point resulting in
death.
https://www.nature.com/articles/s41467-019-13192-4
December 2, 2019

 Twelve people dosed with either Bio-Fisetin or unformulated fisetin.
 Blood levels measured to determine total amount of fisetin that
reached circulation and available to tissues.
 Bio-Fisetin achieved 25-times greater fisetin blood levels relative
to unformulated fisetin.
 Consumer cost of Bio-Fisetin may be half of existing fisetin products.
Human Bioavailability Study
Akay. A cross over pilot pharmacokinetic study of fisetin 1000mg and formulated fisetin 200mg
administered in a single dose to healthy volunteers. (in press for future publication). 2020.

Age Reversal Survey Results
Approximately 550 people completed survey and reported:
79% used NAD+ oral supplements
68% used some type of senolytic
61% engage in varied fasting
47% used metformin drug
40% used a hormone therapy
14% have used rapamycin Fullresultspostedat:age-reversal.net

Reported Benefits from Using Any Form of NAD+
30% had improved energy levels
28% feltimproved well-being
19% had improved cognition
14% had a reduction in body fat
Full results posted at: age-reversal.net

Reported Benefits from Any Form of Fasting
54% had improved sense of well-being
44% had a reduction in excess body fat
34% had improved cognitive function
18%hadpoorcognitivefunctionimproved

Reported Benefits from Using Any Form of HRT
74% had improved sense of well-being
47% had improved cognitive function
43% had reduction of excess body fat
31% improved poor cognitive function
28% had improvementin chronic disorder

https://en.wikipedia.org/wiki/Sumner_Redstone
Redstone built multi-billion-dollar empire.
Donated >$216 million to charities.
Boasted he would live forever.
Dead at age 97 from dementia complications.
Sumner Redstone
1923-2020
Expiration date: Aug. 11, 2020
Net worth > $3-4 billion

Targeting only one pathway
of aging in humans will not
produce a meaningful change
in healthspan or longevity.
Today’s Dilemma

Intervene with a
cocktail of treatments
to improve health as
measured by markers
of biological age.
SOLUTION:

Age Reversal
Interventions
Autophagy Resolve inflammation
Remove
senescent cells
Restore
youthful methylation
Lengthen
telomeres
AMPK/
mTOR
Sirtuins -
NAD+
Exosomes

Clinical Trials Update:
1) Vitality in Aging Interventions Trial
2) Vitality in Aging Longitudinal Study

VIA Interventions Trial
Human Age Reversal Project
pays lab tests + interventions.
(50 people in this study)
VIA Longitudinal Study
You pay (discounted prices) for
lab tests and interventions.
(Everyone should enroll)
To apply or enroll in
VIA studies:
VitalityInAging.org/

Goal: Statistically significant + real world
age reversal in 12-15 months.
Vitality in Aging
Interventions Trial

Fully funded 15-month clinical trial of 50 people.
Vitality in Aging Interventions Trial
Objective: Evaluate a combination of compounds that
individually have been shown to increase healthspan
and/or lifespan in model organisms.
To apply: VitalityInAging.org/
Approximately $20,000 allocated per study subject

Reverse Aging with Combined Interventions
Senolytics NAD+ Sirtuins mTOR
AMPK
Young
Plasma
Factors
Stem Cells
Restore
Immune
Function
MitochondriaExosomes

Vitality in Aging
Interventions Trial
Initial Funding Needed: $530,000
Donations Received: $910,000
Funding supports the:
Open Source Dissemination of Findings

(Need website for donations)
$910,000 + $100,000 = $1,010,000
Donated + Pledged Funding for VIA Intervention Trial:
Goal: Statistically Significant +
Meaningful Age Reversal
> One Million Funding by January 2021

Vitality in Aging Longitudinal Study
(Sign up at: VitalityInAging.org/

Join a team effort to defeat aging!
Identify “risk factors” causing you to age
Access biomarker tests at subsidized prices
Access interventions at discount prices
Test safety & efficacy of self-experimentation
Accelerate science of human age reversal

Step 1 - Enroll in VIA Longitudinal Study - $495
Step 2 - Includes Age Management Blood Test Panel
Step 3 - Use test results to adjust your longevity program
Step 4 - Retest to measure age reversal efficacy
Step 5 - Adjust interventions based on retest results
Modeled after Framingham Heart Study, i.e. long term and ongoing…
ToenrollinVIALongitudinal Study: VitalityInAging.org

Commercial Lab Price: $3,000
Vitality in Aging Price: $495
Age Management BloodTest Panel
VitalityInAging.org

Some paid $595 in 2019 to enroll, but not all tests available.
$200 credit to those who paid $595.
Repeat Age Management Blood Test Panel
RAADfest cost is $495 (or $295 to those with $200 credit)
Longitudinal Study Update
Sign up at: VitalityInAging.org/

 Interleukin-6
 Apolipoprotein B
 Homocysteine
 C-Reactive Protein
 LDLparticle number
 Total cholesterol
 LDL cholesterol
 HDL cholesterol
 Triglycerides
 T. Chol/HDL Ratio
 Est. Heart Disease Risk
+
Conventional Risk Factors
More Tests on Next Slide
AgeManagement TestPanel
Cardiac and Inflammatory Blood Markers
Added RiskFactors
 Small dense LDL
 LDL size
 Insulin Resistance
 VLDL cholesterol
 HDLparticle number

Omega-3 Index + Full Fatty Acid Profile
Omega-3 Fatty Acids
• Omega-3 Index
• Alpha-Linolenic
• Eicosapentaenoic (EPA)
• Docosapentaenoic-n3 (DPA)
• Docosahexaenoic (DHA)
Omega-6 Fatty Acids
• Linoleic + Gamma-Linolenic
• Eicosadienoic
• Dihomo-y-linolenic
• Arachidonic
• Docosatetraenoic
• Docosapentaenoic-n6
Monounsaturated Fats
• Palmitoleic
• Oleic
• Eicosenoic
• Nervonic
Saturated Fatty Acids
• Myristic
• Palmitic
• Stearic
• Arachidic
• Behenic
• Lignoceric
Trans Fatty Acids
• Trans Palmitoleic
• Trans Oleic
• Trans Linoleic
• Trans Fat Index
Fatty Acid Ratios
 AA: EPA ratio
 Omega-6 to-
Omega-3 ratio

Glycemic Control Blood Profile
Insulin
Hemoglobin A1C
Ferritin
Insulin Resistance Score
Glucose
Diabetes Risk Markers

Hormones +Vitamin D + Binding Protein
 IGF-1 (growth hormone)
 IGF1BP3 (binding protein)
 DHEA-S
 Free Testosterone
 Total Testosterone
 Estradiol
 Progesterone
 TSH (thyroid)
 Free T3 and Free T4
 Vitamin D 25-Hydroxy
Hormone Effectiveness Profile

Kidney and Liver Function Biomarkers
 eGFR
 LDH
 AST
 ALT
 GGT
 Bilirubin
 Albumin
 Globulin
 A/G ratio
 Creatinine
 BUN/Creatinine
 BUN
 Total protein
 Alkaline Phosphatase
Measures of Organ Function

Blood Mineral-Electrolyte Balance
Potassium
Magnesium
Ferritin (iron storage)
Measures of Mineral-Electrolyte Balance
Calcium
Iron
Chloride
Sodium

Blood Oxygen Carrying Capacity
 MCV (meancorpuscularvolume)
 MCH (meancorpuscularhemoglobin)
 RDW (redcelldistributionwidth)
 MCHC (meancorpuscularhemoglobinconcentration)
 Platelets
 Hematocrit
 Hemoglobin
 Red blood count
 Ferritin (ironstorage)

Circulating Immune Cell Count
 Immature cells
 White blood cells
 Immature granulocytes
 Neutrophils (% and absolute)
 Lymphocytes (% and absolute)
 Monocytes (% and absolute)
 Eosinophils (% and absolute)
 Basophils (% and absolute)

For Men
PSA
(prostate-specific antigen)

Heart attack &
stroke deaths
increase relative
to cancer in
elderly persons.
Reference: Heron, M. Deaths: Leading Causes for 2017.
National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6.
https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf
Heart Disease Still #1 Killer

https://en.wikipedia.org/wiki/Sumner_Redstone
Redstone built multi-billion-dollar empire.
Boasted he would live forever.
Relied on Brazilian fruit juice to try to stay
alive another 50 years.
Sumner Redstone
1923-2020
Net worth > $3-4 billion

1) Age Management Blood Test Panel on an annual basis. ($495)
2) Completion of online surveys.
3) Mimic VIA Interventions Trial and/or choose your own protocol.
4) Additional surveys sent on specific topics.
5) This is a self-funded study with subsidized prices.
To enroll: VitalityInAging.org/

1) Enlarged, restructured, and improved electronic
data capturing capabilities.
Expanded Remote Data Capturing and Contact-Less Trials
2) Enhanced electronic informed consents,
health questionnaires, surveys, and reminders.
3) Developing remote and virtual testing when possible.

VIA Interventions Trial
pays lab tests + interventions.
(50 people in this study)
VIA Longitudinal Study
You pay (discounted prices) for
lab tests and interventions.
(Everyone should enroll)
To apply or enroll in VIA studies:
VitalityInAging.org/

Procrastination
Our greatest enemy:

https://www.forbes.com/profile/marcel-adams/
Marcel Adams
1920-2020
Net worth $1.6 billion
Marcel Adams immigrated to Canada in 1951 and
built real estate and media empire.
Produced TV shows like “Flipper” and “Miami
Vice”.
Donated $millions to education and charities.
Died at age 100 in his sleep.

Joseph Myron Segel, founder of
the home-shopping behemoth
QVC Network.
Cause of death was congestive
heart failure at the age of 88.Joseph Segel (1931-2019)
Expiration date: Dec. 21, 2019
Net worth > $20 billion www.wharton.upenn.edu/wp-content/uploads/125anniversaryissue/segel.html
Who missed the longevity boat?

David Koch, a billionaire
industrialist, philanthropist died
at 79 with assets worth nearly
$50 billion.
He was diagnosed with prostate
cancer and in declining health.
David Koch (1940 - 2019)
Net worth > $50 billion https://www.cnn.com/2019/08/23/politics/david-koch-dead/

Clayton Williams, a colorful Texas
oilman and philanthropist.
Williams died at his home in
Midland after struggling with
pneumonia. He was 88.
Clayton Williams (1931-2020)
Expiration date: Feb. 14, 2020
Net worth > $1.3 billion https://www.bloomberg.com/news/articles/2020-02-16/oilman-former-texas-governor-candidate-williams-dies-at-88

Multi-billionaire real estate
developer dies of Covid-19
complications at age 78.
Stanley Chera (1942-2020)
Expiration date: Apr. 10, 2020
Net worth > $4.3 billion https://nypost.com/2020/04/13/real-estate-mogul-stanley-chera-dead-at-78-from-coronavirus/
Net worth > $4.3 billion

Fund Reseach with Tax-Deductible Donations
Make checks payable to:
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate

Level 1 essential
to sustain life
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Some RAADfest
Alumni Fail
To Correct
Risk Factors
Death = Failure
Harsh Reality!

Level 1 is essential to
progress to Level 2.
Optimal Health
Level 2
Level 1
- Hormones - Renal function
Correct Your Underlying
Disease Risk Factors
Age Reversal Interventions

House of
Optimal Health
- Hormones - Kidney function
Level 2
Level 1
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Umbilical Cord Blood/Plasma
- Exosomes
- Mesenchymal Stem Cells - Mitochondria Transfer
- Young Plasma
Failure to optimize
Level 1, preclude
benefits of Level 2.
Healthy Aging

Level 1 is essential to
progress to Level 2.
Optimal Health
Level 2
Level 1
- Hormones - Kidney function
Correct Your Underlying
Disease Risk Factors

We Don’t Have Time to
Delay Age Reversal

Death
Denial
Will COVID
Instill Some
Rationality?

Copyright ©Life Extension®. Confidential and proprietary.
How I Fund Age Reversal Research
Supplement Sales Support Rejuvenation Projects

More tax-deductible donations needed to expand research
Make checks payable to:
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate

Sequencing the genome of the bowhead whale was
done to identify candidate genes to explain their long
lifespan and resistance to diseases.
This project helped elucidate genes conferring longevity
and disease resistance that may to improve human health.
Genomic Research Funding
Supported by grants from Life Extension® and the Methuselah Foundation.

Maximum natural
lifespan of bowhead
whales is 268 years.
DNA Methylation Test Reveals
Bowhead Whales Longevity
https://cosmosmagazine.com/biology/life-clock-ticking

October 24, 2019
“GettingComfortablewithRisk”
“...without daring innovators, disruptive
thinkers, and voluntary patients, little
medical progress could be made”
https://www.nejm.org/doi/full/10.1056/NEJMp1906872

Unparalleled Track Record
of Biomedical Innovation
Established 1977

age-reversal.net
This entire presentation available at:

These slides available for review at: www.age-reversal.net
AgeReversalUpdate
William Faloon
October 3rd 2020
RAADfest 2020

Bill Faloon at RAADfest 2020

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