Bill Faloon presented an age reversal update on a webinar hosted by the Coalition for Radical Life Extension on January 23rd, 2021. These are his presentation slides.
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Bill Faloon's presentation for Age Reversal webinar on Jan 23rd 2021
1. These slides available for review at: www.age-reversal.net
Age Reversal Update
William Faloon
January 23, 2021
2. 98-Year Average Lifespan?
25% Lifespan Extension
It May Be Possible for Normal Aged People to
Benefit from these Kinds of Single-Gene Crispr Edit
If this Crispr-Treatment Works Similar in Normal Aged Humans
Crispr-Treated Normal AgedMouse
Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
3. Crispr-Treated Progeroid Mouse
17 Months
>160 Years?
7.1 Months
Combination Crispr-Treated Human
Untreated Progeroid Mouse
https://www.nature.com/articles/s41586-020-03086-7 https://doi.org/10.1073/pnas.1910073116
Extrapolation Assuming
Normal Aged People
Can Have Multi-Gene Edits
via Crispr
6. “Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019
Human Age Reversal Demonstrated in 2019
1) Human growth hormone
2) DHEA
3) Metformin
Study conducted by Dr. Greg Fahy in collaboration
with researchers from Stanford University and
UCLA consisted of individualized doses of:
Study subjects also provided with daily
vitamin D3 and zinc.
8. Intervene Immune’s TRIIM-X Study:
Thymus Regeneration Trial Enrolling
Now 100 healthy 50–80-year-olds targeting
reversal of immune system decline.
Study volunteers can enroll remotely
from across the U.S.
Intensive immune system and
epigenetic age monitoring.
Personalized drug cocktail reversed
epigenetic age by >2.5 years in healthy
men in TRIIM trial at Stanford.
Find out more:
www.ClinicalTrials.gov NCT04375657
GrimAge
9. Dec. 30, 2020
https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/
Mainstream Recognition of
The Need to Reverse Human Aging
“Age is the biggest risk factor for cancer,
cardiovasculardisease,andneurodegeneration.
Withouttreatmentsto slowor reverseaspects
of biologicalaging,anagingpopulationmeans
we areinfor ahealthcarecosttsunami.
With such treatments, Americans would
experiencemorehealthy,productiveyearsoflife.”
10. “…why not launch an
Operation Warp Speed
for biological aging?”
CONCLUSION
https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/
11. Our Groups Recognized the Urgency
Sought Validated Methods to
Reverse Aging in People
Manhattan Beach Summit
November 2009
12. Huge Advances in 12 Years
No Way to Reverse Aging
Manhattan Beach Summit Attendees
November 2009
Many Potential Methods
2009 2021
13. December 2, 2015
George Church, Ph.D.
A Cure for Aging by Year 2030?
https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/
17. Progeria is a rare, progressive genetic disorder that causes children to age rapidly,
starting in their first two years of life.
Children with progeria generally appear normal at birth. During the first year, signs and
symptoms, such as slow growth and hair loss, begin to appear.
Heart problems or strokes are the eventual cause of death in most children with progeria.
The average life expectancy for a child with progeria is about 13 years. Some with the
disease may die younger and others may live longer, even up to 20 years.
There's no cure for progeria, but ongoing research shows some promise for treatment.
Progeria
https://www.mayoclinic.org/diseases-conditions/progeria/symptoms-causes/syc-20356038
Rapid Accelerated Aging
19. Crispr Gene-Editing Treatment
An untreated progeria mouse at 7.5
months of age, with a thin, grayish
coat, pronounced spinal curvature,
and low activity levels. Untreated
progeria mice have an average
lifespan of 7.1 months.
Three treated progeria mice at 11
months of age, with healthy
coats, no apparent spinal
curvature, and normal activity
levels. The treated progeria mice
had an average lifespan of 17
months.
CRISPR-Edited
Heathy Mice
Unedited
Rapid-Aged
Mouse
https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
20. Crispr Therapy Corrects Pathologic Mutations in DNA Genes
Healthy Longevity Conferred by Replacing Progeroid DNA
base pair T and A with Normal C and G DNA base pair
https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
21. 1. A ‘base editor’ was designed to home
in on this mutation and correct it to the
normal sequence. The molecule was put
into a special inactivated virus.
How this Gene
Editing Therapy
Extended Life
https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
24. OptimisticExtrapolationofCrisprMouseStudytoHumanAging
Untreated progeria mice average lifespan: 7.1 months1
Crispr-treated progeria mice average lifespan: 17 months1
Untreated normal human lifespan: 78 years
Combination Crispr-treated human lifespans: >160 years
Human age reversal will require combination Crispr-like gene therapies2
1.https://www.nature.com/articles/s41586-020-03086-7
2. PNAS November 19, 2019 116 (47) 23505-23511; https://doi.org/10.1073/pnas.1910073116
25. Untreated Progeroid Mouse
Crispr-Treated Progeroid Mouse
7.1 months
17 months
Combination Crispr-Treated Human
> 160 Years?
Extrapolation Assuming Normal Aged People
Can Have Multi-Gene Edits via Crispr
https://www.nature.com/articles/s41586-020-03086-7
https://doi.org/10.1073/pnas.1910073116
26. Results from single dose combination gene therapy:
Noah Davidsohn, Matthew Pezone, Andyna Vernet, Amanda Graveline, Daniel Oliver, Shimyn Slomovic, Sukanya
Punthambaker, Xiaoming Sun, Ronglih Liao, Joseph V. Bonventre, and View ORCID Profile George M. Church
PNAS November 19, 2019 116 (47) 23505-23511; https://doi.org/10.1073/pnas.1910073116
November 19, 2019
1)58%increasedfunctionafterheartfailure
2)38%reductioninvasculardiseasemarker
3) 75% reduction in kidney atrophy
4)Complete reversal ofobesity &diabetes
27. 1) 25% extended lifespan in normal aged mice.1
2) Improved overall appearance and grip strength.1
“A genome-wide CRISPR-based screen identifies
KAT7 as a driver of cellular senescence”
January 6, 2021
1. https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf
2. https://www.genome.gov/10001345/importance-of-mouse-genome
Mice and humans share virtually the same set of genes though in slightly different forms.2
KAT7 gene is significant driver of cell senescence. Targeting KAT7 using CRISPR enabled:
28. Crispr-Treated Normal Aged Mouse
25% Lifespan Extension
If this Crispr-Treatment Works Similar in Normal Aged Humans
98-Year Average Lifespan?
Extrapolation Assuming Normal
Aged People Benefit from this Single-Gene Crispr Edit
https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf
29. Maximum natural lifespan of
bowhead whales is 268 years.
DNA Genes of Bowhead Whale Sequenced
For Human Crispr Replication Studies
https://cosmosmagazine.com/biology/life-clock-ticking
Supported by grants from Life Extension® and the Methuselah Foundation.
Crispr-edited human DNA will
soon be studied using bowhead
whale genome.
30. Do You Want Un-Edited Genes? or Precisely Edited Genes?
Rough Draft Manuscript Finalized “Edited” Publication
or
32. DEC. 8, 2019
“A Harvard geneticist's goal: to
protect humans from viruses,
genetic diseases, and aging”
“George Church's lab at Harvard Medical School is
working to make humans immune to all viruses, eliminate
genetic diseases and reverse the aging process…”
33. December 2, 2015
George Church, Ph.D.
A Cure for Aging by Year 2030?
https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/
35. “In the multi-variable model,
high adherence to the
Mediterranean diet was
associated with 25% lower
risk of death as compared
with the lowest category.”
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/mediterranean-diet-and-mortality-in-
the-elderly-a-prospective-cohort-study-and-a-metaanalysis/F2D6B083AA187849477112DB77820521
“Mediterranean diet and mortality
in the elderly: a prospective cohort
study and a meta-analysis”
Published online by Cambridge University Press: 30 August 2018
36. Mediterranean diet and longevity
A. Trichopoulou* and E. Vasilopoulou
University of Athens Medical School, Department of Hygiene and Epidemiology, Mikras Asias 75, 115 27 Athens, Greece
British Journal of Nutrition (2000), 84, Suppl. 2, S205±S209
The conclusion of these studies is that a diet that adheres to the principles of the
traditional Mediterranean one is associated with longer survival. The Greek
version of the Mediterranean diet is dominated by the consumption of olive oil
and by high consumption of vegetables and fruits. Antioxidants represent a
common element in these foods and an antioxidant action provides a plausible
explanation for the apparent benefits. Wild edible greens frequently eaten in rural
Greece in the form of salads and pies contain very high quantities of flavonoids
considerably higher than those found in red wine or black tea. While there is no
direct evidence that these antioxidants are central to the benefits of the
Mediterranean Diet, indirect evidence from epidemiological data and the
increasing understanding of their mechanisms of action suggest that antioxidants
may play a major role.
https://www.researchgate.net/profile/Effie_Vasilopoulou/publication/12090631_Mediterranean_diet_and_longevity/links/00b4951e39aed3d079000000.pdf
37. May 2008 Sept 2016
April 2015
Longevity Benefits of Mediterranean Diet
42. Foods like instant noodles and soups, breakfast cereals and
chicken nuggets were associated with an earlier death.
Feb. 29, 2019
The authors suggest that high-
temperature processing may form
contaminants, that additives may
be carcinogenic, and that the
packaging of prepared foods can
lead to contamination.
https://www.nytimes.com/2019/02/12/well/eat/eating-processed-foods-longevity-death-mortality.html
Avoid High Temperature Cooked Foods
43. New evidence links ultra-processed
foods with a range of health risks May 29, 2019
Two large European studies
find positive associations
between consumption of
highly processed ('ultra-
processed') foods and risk
of cardiovascular disease
and death.
https://www.sciencedaily.com/releases/2019/05/190529221040.htm
44. Small Increases in Ultra-processed Food Intake
Markedly Increases Incidence of Stroke and Heart Attack
May 29, 2019
Results showed that an absolute
10% increase in the proportion of
ultra-processed food in the diet was
associated with significantly higher
rates of overall cardiovascular
disease, coronary heart disease, and
cerebrovascular disease (increase of
12%, 13%, and 11% respectively).
https://www.sciencedaily.com/releases/2019/05/190529221040.htm
45. LowerDiseaseRiskWithUnprocessed
Or Minimally Processed Foods
May 29, 2019
In contrast,the researchers
found a significant
association between
unprocessed or minimally
processed foods and lower
risks of all reported diseases.
https://www.sciencedaily.com/releases/2019/05/190529221040.htm
46. "Ultra-processed" foods linked to
heart disease, early death
May 30, 2019
In the second study — of nearly 20,000 Spanish
adults — ultra-processed foods were linked to a
shorter life span:
Those with the highest intake were 62% more likely
to die over two decades, compared to those with the
lowest intake.
https://www.cbsnews.com/news/ultra-processed-foods-linked-to-heart-disease-early-death/
47. January 7, 2021
Adherence to the Mediterranean diet and grade group
progression in localized prostate cancer: An active
surveillance cohort
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33182
Each one-unit improved adherence to the Mediterranean diet was
associated with a 12% lower trend of aggressive (high Gleason score)
prostate cancer detrimental progression.
A four-unit improved Mediterranean diet score would equate to a 48%
associated lower trend of prostate cancer progression.
48. Longitudinal Study Update
Vitality in Aging Research Group has shifted into the digital realm.
With a new electronic consenting and secure online data capturing platform.
To enroll, select "Enroll Now" hyperlink on Vitality in Aging website to create:
VIA Longitudinal Study of Aging Account Profile
Annual requirements for the study:
1) Age Management Blood Test Panel with Omega-3 Index Kit ($495)
2) Online Health Questionnaires
The VIA Longitudinal Study of Aging will collect data for 10 years.
To apply or enroll in VIA studies: VitalityInAging.org/
49. “Plasma dilution improves cognition and
attenuates neuroinflammation in old mice”
“Explaining the mechanism of the positive effects of
neutral blood exchange on the brain, our
comparative proteomics analysis demonstrated that
dilution of old blood plasma yields an increase in the
determinants of brain maintenance and repair in
mice and in people.
These findings confirm the paradigm of rejuvenation
through dilution of age-elevated systemic factors
and extrapolate it to brain health and function.”
https://link.springer.com/article/10.1007/s11357-020-00297-8
November 15, 2020
50. Sheldon G. Adelson, a cabdriver’s son who built
the world’s largest empire of casinos and resort
hotels in Las Vegas, Macau, Singapore and other
gambling meccas.
The cause was complications of non-Hodgkin’s
lymphoma.
Donated to many charities including some that
supported medical research.
Who missed the longevity boat?
Sheldon Adelson
(1933 - 2021)
Expiration date: Jan. 11, 2021
net worth > $35.8 billion https://www.palmerfuneralhomes.com/obituary/Arthur-Decio
51. Human Age Reversal Project
$1,018,600
Donations for
Vitality in Aging
Intervention Trial:
Goal: Statistically Significant +
Real World Age Reversal
52. Fund Research with Tax-Deductible Donations
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
55. Crispr-Treated Normal Aged Mouse
25% Lifespan Extension
If this Crispr-Treatment Works Similar in Normal Aged Humans
98-Year Average Lifespan?
Extrapolation Assuming Normal
Aged People Benefit from this Single-Gene Crispr Edit
https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf
56. Untreated Progeroid Mouse
Crispr-Treated Progeroid Mouse
7.1 months
17 months
Combination Crispr-Treated Human
> 160 Years?
Extrapolation Assuming Normal Aged People
Can Have Multi- Gene Edits via Crispr
https://www.nature.com/articles/s41586-020-03086-7
https://doi.org/10.1073/pnas.1910073116
58. 98-Year Average Lifespan?
Extrapolation Assuming Normal Aged People
Can Have Multi-Gene Edits via Crispr
25% Lifespan Extension
If this Crispr-Treatment Works Similar in Normal Aged Humans
Crispr-Treated Normal AgedMouse
Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
59. > 160 Years?
17 Months
If this Crispr-Treatment Works Similar in Normal Aged Humans
Crispr-Treated ProgeriodMouse
Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
Untreated ProgeroidMouse
7.1 Months
In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
For those who don’t know about the Life Extension group, we were established back in 1977. For 42 consecutive years we battled government bureaucrats while identifying methods to delay aging and prevent degenerative disease.
In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.