This document summarizes various hemostatic agents and tissue sealants used in surgery. It discusses collagen products, oxidized regenerated cellulose, gelatin sponges, flowable gelatins, thrombin, and fibrin sealants. For each product, it describes the composition, mechanisms of action, advantages, disadvantages, and differences between brands. The document provides an overview of the history and development of hemostatic agents over the past century.
1. Use of Tissue Sealants and Hemostatic Agents in Surgery Martha K. Terris, M.D. Medical College of Georgia
2. Hemostasis “life in the balance” CVA MI DVT PE Trauma Surgery Anticoagulation Hemophilia Bleeding to Death Clotting to Death
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5. A Century of Hemostasis Surgeons today have an impressive set of tools to manage intra-operative bleeding. But how do you know what to use? 1900 1950 2000 Clamps Clips Sutures Direct Compression Bone wax Electrocautery Laser Argon beam ORC Gelatin Thrombin Flowable gelatin Fibrin Sealants Synthetic Sealants
47. Isolation of anti-Bovine Thrombin Antibodies 1989 90 91 92 93 94 95 96 97 98 99 00 01 Clinical Reports of Patients with Major Complications from Antibodies Prospective Analysis of Thrombin Exposure in Surgical Patients Autoimmune Processes Linked with Use of Bovine Thrombin