Safe Prescribing of Second Line Combined Oral Contraceptive
1. 1
Safe PrescribingSafe Prescribing
ofof
Second LineSecond Line
Combined OralCombined Oral
ContraceptiveContraceptive
A workbook for GPA workbook for GP
traineestrainees
Dr Catherine Hyde
3. 3
Contents
Page
2. Using this Workbook : Who, What, How
3. What you need to know to do this workbook
4. Revision of Different pills
5. Pill Safety – the pill check
6. Reasons for changing the pill
7. Case 1 Progesterone side-effects
8. Case 2 Oestogen side-effects
9. Case 3 Break through bleeding
11. Practical tips
12. Summary
13. Evaluation
14. Sources
15. Appendix 1. Medicines Eligibility Criteria categories
16. Appendix 2. Medicines Eligibility Criteria for Combined Oral Contraceptive
17. Appendix 3. Advice for women missing Combined Oral Contraceptive Pills
18. Appendix 4. MIMS – Composition of Combined Oral Contraceptive Pills
Activities index
Page ACTIVITY
3. ACTIVITY 1: Medical Eligibility Criteria (MEC) For Contraceptive Use
4. ACTIVITY 2: Different COC Pills.
7. ACTIVITY 3: Side Effects of Progesterogens
8. ACTIVITY 4:Options for changing the Pill to reduce Progesterogenic side-effects
9. ACTIVITY 5: Options for Changing the pill to reduce oestrogenic side effects
10. ACTIVITY 6: Advice for missed low dose COC
10. ACTIVITY 7: Forming differential diagnosis for Breakthrough Bleeding
10. ACTIVITY 8: Forming management for Breakthrough Bleeding
4. 4
Using this workbook
Who should use the book?
This book is designed for GP trainees to provide a solution to the problem of how to
safely prescribe a second line combined oral contraceptive (COC) pill.
It may be useful by anyone who has experience, and learning needs, in family planning
work.
I realised the need for producing this workbook came while I was watching a powerpoint
presentation on the topic. It was presented by a GP trainee and she was struggling with
a case, as I also had. I realised:
It is a common scenario
It is important
there is evidence and good practice to guide us
The GP trainee’s name was Aisha, and she will provide a trainee
viewpoint to help guide you throughout this workbook.
GP curriculum objectives covered are:
Contraception – effectiveness rates, risks, benefits and appropriate selection
of patients for all methods
Contraception – the safe provision of all methods of oral contraception
Aims : by the end of this book you should be able to:
1) Demonstrate how perform a pill check
2) Demonstrate how to elicit common side-effects of the COC pill
3) Demonstrate how to start an alternative choice of COC pill
How should it be used?
Activity Time Reference
Most learning comes from
completing the activities in this
workbook
See the contents page for a list
of activities
you can do it all in one go
you can complete just one
section
Each section takes 5-10 mins
Contents of different pills and
WHO Medicine Eligibility
Criteria are in the Appendix
pages15-18
Yellow boxes in the workbook
have additional information
Hi there! I’m Aisha, a GP trainee – so
WHAT will I learn from the workbook?
5. 5
What you need to know to do this workbook
Why is this topic important?
24% of women use the COC in the UK making is second favourite choice after
condoms1
Side-effects are common, can be life-threatening, can indicate misuse and can put
the patient at risk of pregnancy.
We expect you to know how to:
conduct a consultation
take a medical and sexual history
do appropriate examination
give information
check understanding
use your basic sciences knowledge
prescribe the COC pill safely for the first time
ACTIVITY 1 - Medical Eligibility Criteria (MEC) For Contraceptive Use
What to do: draw a line between the MEC Category, and the correct definition of
risk
Ok. So I did this for my Diploma of
Family Planning, but after 18 months
stuck in hospital I’ve forgotten
everything. Where can I remind
myself?
The Faculty of Family planning
(FPRHC)& GP notebook provide great
guidance – look in the ‘Sources’, Page 14
MEC Definition of MEC risk
Category
1 A a condition which represents an unacceptable health risk if the
contraceptive method is used.
2 C a condition for which there is no restriction for the use of the contraceptive
method.
3 B a condition where the theoretical or proven risks usually outweigh the
advantages of using the method.
4 D a condition where the advantages of using the method generally outweigh
the theoretical or proven risks.
6. 6
Revision of Different Pills
All combined oral contraceptive pills contain 2 different hormones ____________ and a
progesterogen.
Drug :Oestrogen may be either ______ estradiol or its prodrug __________ (which is converted
in vivo into estradiol).
Dose: Standard strength contains ethinylestradiol 30 or 35micrograms or (30– 40microgram
biphasic or _________ preparations).
Low dose contains ethinylestradiol ___ micrograms
Progesterogens
2nd
Generation progesterogens are Norethisterone and ____________. They are associated
with a lower risk of venous thromboembolism . Therefore they should be the first choice when
prescribing the COC.
First choice of pill should:
• contain either of these progestrogens
• be monophasic
• contain 30 micrograms of ethinylestradiol
In practice this means prescribing __________,
Ovranette, Brevinor, Loestrin 30.
3rd
Generation
Use these words to fill in the blanks if you are finding this tough:
Levonorgestel, 20, oestrogen, mestranol, triphasic, Microgynon 30, Femodene,
Drospirenone, ethinyl, norgestimate.
For confirmation of answers, see Appendix 4, page18
Progestrogen Special Features of Drug Pill containing this drug
desogestrel Less counteractivity against oestrogen Marvelon
___________ Cilest
gestodene _____________
___________ Derived from spironolactone
Caution in renal failure/high potassium
Yasmin
Circumstance
not using COC
and not pregnant
using a 2nd
generation
COC
Using a 3rd
generation
COC
pregnant
VTE Risk per 100,000
woman -years
5
15
25
60
Table 1 Risk of venous thromboembolism (VTE)
associated with combined oral contraception (COC) use
and non-use
ACTIVITY 2 –Different COC Pills.
What to do: fill in the blanks with the correct word (answers at bottom of the page if
needed)
7. 7
Pill Safety – the Pill check
What to do in the follow-up consultation
Check :
Has she found it easy to use?
Has she noticed any adverse effects?
Does she understand how to take it?
Does she know how to manage missed pills?
Has the pattern of withdrawal bleeds been
regular?
Has there been any breakthrough bleeding?
In every follow up consultation, we need to check
Blood pressure
Is it still the best choice of contraception?
any change in circumstances
Is it still safe?
Any relevant change in Medical/family history that may
alter MEC category (see Table 2)
Cervical smear status
Sexual health screening (Awareness and need of
services)& using condoms
So the blood pressure is fine, she doesn’t have
any problems and we’ve discussed the
important information. What now?
Excellent! Prescribe another 6-12
months of the same pill, and advise her to come
back if there are any problems.
Risk Factor Cut off – UKMEC>2
Smoking If Age>35yrs
Migraine With Aura
Or if Age>35yrs
BMI ≥35 kg/m2
Blood
pressure
Consistently 140-159/
90-94
>160/95 – stop
immediately
VTE Personal or FH<45yrs
CVD/Stoke Multiple risk factors of
personal history
Medication Long term liver enzyme
inducers
Surgery Major surgery with
immoblisation
Table 2: Risk factor for harm when using the COC
and instances when UKMEC category is 3/4
8. 8
Reasons for changing pill
1.Breakthrough bleeding
Is common1&2
Up to 30% of women experience irregular bleeding during the first cycle2
Usually resolves after 3 cycles2
Does not indicate that the pill has reduced contraceptive effect (as long as it is being taken
properly) 3
We need to consider
2. Side-effects
Progestrogen
scanty menses
leukorrhoea, dry vagina
breast tenderness
dull type of headache –
often of pill withdrawal
appetite increase, weight gain
premenstrual depression
leg cramps, softening of ligaments
acne, greasy hair
vaginal dryness
So after 2 months on the pill, a woman comes back.
She’s not happy with the pill and wants to change.
What now?
Well, we still need to do a formal pill check (see page
5) to ensure that its safe and right to continue with a COC.
Then we need to explore her reasons.
Oestrogen
menorrhagia
cervical ectopy
breast fullness
migraine type headaches
fluid retention
weight gain (fluid)
tiredness, irritability
nausea
bloating
Compliance - how/when is the pill being taken
Interference - has there been vomiting within 2 hrs of taking the pill, diarrhoea, or any drug
interactions (including St.John’s Wort/herbal remedies)
Pregnancy - interuterine or ectopic
Infection - Chlamydia and Sexually Transmitted Infections
Pathology - endometrial or cervical polyp
- cervical cancer/CIN
Endocrine - hypo/hyperthroidism
Blood - bleeding disorders
9. 9
Progesterogen case
Lisa is a 21 year old women
She comes to see you after 3 months taking Microgynon 30
(Ethinylestradiol 30 microgram, levonorgestrel 150 microgram)
She complains of
increased appetite
acne
low mood before her withdrawal bleed
She was previously on injection which she stopped due to weight gain and low mood,
and then she used condoms for 6 months
ACTIVITY 4: Options for Changing the pill
What to do: Fill in the blank with the correct pill name
1. Light withdrawal bleed
2. Increased white vaginal discharge
3. Leg cramps
4. Heavy withdrawal bleeds
5. Breast tenderness
6. Greasy hair
7. Vaginal dryness
8. Fluid retention
True / False
True / False
True / False
True / False
True / False
True / False
True / False
True / False
ACTIVITY 3:Side Effects of Progesterogens
What to do: circle True if the symptom is cause by progesterogens, False if not
(answers at bottom of page)
ACTIVITY3.Answers1.T2.T3.T4.F9associatedwithoestrogen)5.T6.T7.T8.F(Associatedwith
oestrogen)
Action to reduce side-
effects
New Pill content New Pill name
Reduce progesterogen
content
Not an option in this case
Increase oestrogen 35 micrograms of ethinyl oestradiol
500 micrograms norethisterone
Ovysmen and
i)__________
Change to less
androgenic progestrogen
30 micrograms of ethinyl oestradiol
150 micrograms desogestrel
ii)_________
Change to 3rd generation
progesterogen e,g.
35 microgram of ethinyl estradiol
norgestimate 0·25 mg
iii)________
10. 10
Oestrogen case
Seema is a 19 yr old woman
She has just started a new relationship
She has taken 3 months of Brevinor, which her friend had recommended
(contains Ethinylestradiol 35 microgram/norethisterone 0·5 mg)
She complains of :
increased appetite
heavy period
tiredness
nausea and bloating
ACTIVITY 5: Options for Changing the pill to reduce oestrogenic side effects
What to do: Fill in the blank with the correct pill name
Action Pill content Pill name
Original pill 35 microgram ethinyl oestradiol
0·5 mg norethisterone
Brevinor
Dose
:
Reduce oestrogen
content
<35 micrograms ethinyl oestradiol
20 micrograms ethinyl oestradiol
1 mg norethisterone acetate
All pills except
a)_________ &
Norimin
Loestrin 20
Increase progesterogen
content
30 micrograms ethinyl estradiol
1.5 mg norethisterone acetate
Loestrin 30
Type Alternative oestrogen type 50 micrograms Mestranol
1 mg norethisterone
b)_________
Is it safe to prescribe a low strength oestrogen pill (eg 20 micrograms
ethinyl oestradiol )?
Efficacy of 20mcg and 30mcg pills are similar, but breakthrough bleeding
is more common with the lower dose3
.
Missed pill advice is also more cautious in lower dose pills. If 2 or more pills
are missed, extra protection needs to be used for 7 days, and you need to
consider if emergency contraception is required (see appendix page 17).
Low dose dose oestrogen is available with Northisterone, Gestodene,
Drospirenone and Desorgestrel.
ACTIVITY4:Answersi)Brevinorii)Marveloniii)Cilest
ACTIVITY5:Answersa)Ovysmenb)Norinyl-1
11. 11
Breakthrough Bleeding Case
Helen is a 18 yr old woman
She has just started a new relationship
She has taken 6 weeks of Loestrin 20, which her friend had recommended
(contains ethinylestradiol 20 microgram/1mg norethisterone)
She complains of :
A small amount of bleeding every day
You take a thorough history – which reveals she has missed 2 pills during the past week
(week 2 of the current pill packet). She has not had unprotected intercourse since her last
proper period.
ACTIVITY 6:You advise her to:
What to do: circle True if you would give the advice, False if not (answers overleaf)
You emphasise it is important to take the pill regularly ( though one pill may be missed in
the month without affecting contraception). You reassure that most bleeding settles after
3
months.
At 3 months she comes to see you – she is still experiencing spotting every day.
History reveals she has been taking the pill regularly, she has had intercourse without
condoms since the last withdrawal bleed. She had post-coital bleeding yesterday.
ACTIVITY 7: What are you concerned about?
write a differential diagnosis below ACTIVITY 8: What will you do next
Form a management plan below
i) use extra protection for the next 7 days True/False
ii) use emergency contraception True/False
iii) run this pill packet into the next True/False
a) __________________
b) __________________
c) __________________
d) __________________
e) __________________
f) __________________
1. _____________________________
2. _____________________________
3. _____________________________
4. _____________________________
5. _____________________________
12. 12
Breakthrough Bleeding Case
The Case continues:
Answers to ACTIVITY 6
You correctly advise that she use extra protection for the next 7 days as she was on a low dose
pill. She does not need to have emergency contraception, as there had been no intercourse &
as she has missed pills in week 2 – there was no need to run pill packets together ( see
appendix – page if you’re still not sure).
ACTIVITY 7&8
Your immediate concern is the possibility of ectopic pregnancy, then possible interuterine
pregnancy and pelvic inflammatory disease. The differential is fairly wide – you can discuss this
futher with your GP trainer & colleagues (& refer back to page 6).
You carefully examine:
Abdomen is soft, non-tender.
All obervations are normal.
pelvic exam is normal, cervix looks healthy & there was no cervicitis. There is a significant
amount of greenish discharge. You take a smear, high vaginal and endocervical swabs.
You are lucky to have pregnancy tests available in the practice – which is negative.
Are you happy this woman is not in immediate danger ?___________________________
You send her home, advising to her continue with this pill, but use extra protection until the
results of the swabs are back.
3 days later – the swab results show evidence of gonorrhoea infection. You treat this with a
single oral dose cefixime 400mg & urinary rescreen at day 16 is clear. However, the
breakthrough bleeding is still an issue.
What will you do next? Select one of option a) to e)_____
(all options are suitable, and a combination of changes can also be effective)
Action Pill content Pill name
a) Increase oestrogen content 35 micrograms of ethinyl
oestradiol 1 milligram
norethisterone
Norimin
b) Change dose of
progesterone
35 micrograms of ethinyl
oestradiol 500 micrograms
norethisterone
Brevinor
c) Alternative 2nd
generation
progesterogen
30 micrograms of ethinyl
oestradiol 150 micrograms
levonorgestrel
Micrgynon or
Ovranette
d) 3rd
generation
progesterogen
20 micrograms of ethinyl
oestradiol /gestodene
75 microgram
Femodette
e) Change to triphasic pill Ethinyl oestradiol &levonorgestrol logynon
13. 13
Practical Tips
When I prescribe the Microgynon – it always gives me
an ‘Microgynon ED’ choice. Does Microgynon treat ED
too?!
ED stand for EveryDay – these pills contain 21 active
pills (beige in microgynon)& 7 inactive pills (white in
microgynon). So women take one tablet every day& start the
next packet without a break.
When do I prescribe Dianette?
Dianette is 2 mg cyproterone acetate, 35 micrograms ethinylestradiol. It has
greater anti-testosterone activity, but also increased risk of
thromboembolism. It is not licensed for contraception alone– though it does
work as a COC!
It is only licensed for severe acne not responding to prolonged oral
antibiotics, or moderately severe hirsutism.
It needs to be stopped 3-4 months after acne or hair-growth completely
resolve, but can be restarted subsequently.
So how, practically, does a women start that second choice of pill I
have prescribed?
1. Prescribe 3 months of the new pill
2. Advise that she starts the pill after taking 21 days of the first type of pill
– ie she does not have a withdrawal bleed.
(If she is taking an EveryDay pill – she shouldn’t take any of the last
7(inactive) pills but start the new pill after the active pills)
14. 14
Summary
In this workbook you have worked though:
Revision of different pills
Pill Safety – how to do a pill check
Reasons for changing the pill
A case of Progesterone side-effects
A case of Oestogen side-effects
A case of Break through bleeding
Practical tips on pill changing
GP curriculum objectives guiding learning were:
Contraception – effectiveness rates, risks, benefits and appropriate
selection of patients for all methods
Contraception – the safe provision of all methods of oral
contraception
Aims : you should now be able to:
1) Demonstrate how perform a pill check
2) Demonstrate how to elicit common side-effects of the COC pill
3) Demonstrate how to start an alternative choice of COC pill
Self summary:
In doing this workbook I learnt __________________________________________
____________________________________________________________________
____________________________________________________________________
15. 15
Evaluation
We would be really grateful I you could fill in the following and send it to us, so that we can
continue to improve the workbook. Please keep a copy of your self-evaluation.
Self-Evaluation
What to do: Please rate how strongly you agree or disagree with each of the following
statements by circling the appropriate statement.
1) I know how to perform a pill check
Strongly Disagree Somewhat Disagree Somewhat Agree Strongly Agree
Comments ___________________________________________________________
____________________________________________________________________
2) I know how to elicit common side-effects of the COC pill
Strongly Disagree Somewhat Disagree Somewhat Agree Strongly Agree
Comments ___________________________________________________________
____________________________________________________________________
3) I know how to start an alternative choice of COC pill
Strongly Disagree Somewhat Disagree Somewhat Agree Strongly Agree
Comments ___________________________________________________________
____________________________________________________________________
Workbook evaluation
1.One thing that I found useful about this workbook was….
____________________________________________________________________
____________________________________________________________________
2.One thing I thought could be done better in this workbook was…
____________________________________________________________________
____________________________________________________________________
Any additional comments….
____________________________________________________________________
____________________________________________________________________
16. 16
Sources
Sources & Further Reading
1.BNF: http://www.bnf.org/
2.Faculty of sexual and reproductive health www.ffprhc.org.uk/
3. www.gpnotebook.co.uk
4.www.patient.co.uk/
5. MIMS www.healthcarerepublic.com/
References
1. McMorran J, Crowther DC, McMorran S, Prince C, YoungMin S, Pleat J, et
al. Contraception – general overview. [cited 6th March 2009]; Available
from: http://www.gpnotebook.co.uk/simplepage.cfm?ID=-617283574
2. Willacy H. Contraception - General Overview. Patient.co.uk 2008 [cited 6th
March 2009]; Available from: http://www.patient.co.uk/showdoc/40000129/
3. FFPRHC guidance. First prescription of combined oral contraception. J Fam
Plann Reprod Health Care 2003;29(4):209-23
4. Faculty of Family Planning and Reproductive Health Care. UK MEDICAL
ELIGIBILITY CRITERIA FOR CONTRACEPTIVE USE (UKMEC 2005/2006).
Faculty of Family Planning and Reproductive Health Care. 2006. Available
from: http://www.ffprhc.org.uk/admin/uploads/298_UKMEC_200506.pdf
17. 17
Appendicies
Page
16. Appendix 1. Medicines Eligibility Criteria categories3
17. Appendix 2. Medicines Eligibility Criteria for Combined Oral Contraceptive4
18. Appendix 3. Advice for women missing Combined Oral Contraceptive Pills3
19. Appendix 4. MIMS – Composition of Combined Oral Contraceptive Pills5
Appendix 1: Medicines Eligibility Criteria Catagories 3
UKMEC 1 A condition for which there is no restriction for the use of
the contraceptive method
UKMEC 2 A condition for which the advantages of using the method
generally outweigh the theoretical or proven risks
UKMEC 3 A condition where the theoretical or proven risks usually
outweigh the advantages of using the methoda
UKMEC 4 A condition which represents an unacceptable health risk if
the contraceptive method is used
Who is this for – ASSURE analysis
Aims – GP curriculum allign with learners objectives/motivation -
Contraception – effectiveness rates, risks, benefits and appropriate selection of patients for all methods,
including methods of emergency contraception
Contraception – the safe provision of all methods of oral contraception (including emergency hormonal
Relate to own experience. Dialogue style ( Lockwood)
How should it be used
Active learning – knowles
Activites – lockwood
Dip in/out, all at once/reference – reflected in clarity of titles/ different page types, contents page
Background knowledge - expected
Refresh - advance organiser (cognitivism)
Theories – instructional design theory ( systematic development of instructional specifications – ie storyboard)
Cognitivism - chunking into meaningful parts & memonics
well organised
clearly structured
prior knowledge important
perceptual aspects of design important
Oral contraception is used by 25 - 30% of couples in the UK. It is highly effective and in addition to preventing pregnancy, it may be used to manage irregular menstrual cycles and to ameliorate dysmenorrhoea. Preparations with low doses of oestrogen and relatively more progestogen may be used to manage endometriosis.
Factors to consider when choosing a preparation include:
patient&apos;s age
smoking habit
pre-existing acne / hirsutism
cost
. FOLLOW-UP (Women should be encouraged to use a COC for at least 3 months before considering an alternative)
A follow-up at 3 months allows an assessment of blood pressure and problems and re-instruction if required. In the absence of special problems, a
12-month supply of COC can be given at follow-up. Women should be encouraged to return if any problems arise.
INSTRUCTIONS FOR USE
A monophasic COC containing 30 μg (micrograms) of ethinylestradiol with norethisterone or levonorgestrel is a suitable first pill.
One pill should be taken daily for 21 days followed by 7 pill-free days. Women may choose to take more than one packet of pills continuously
followed by a 7-day pill-free interval.
COC may be started up to and including Day 5 of the menstrual cycle without the need for additional barrier contraception. COC can be started at
other times if it is reasonably certain a woman is not pregnant but additional barrier contraception is required for the first 7 days of pill taking.
If vomiting occurs within 2 hours of pill taking another pill should be taken as soon as possible. With persistent vomiting or severe diarrhoea for
&gt;24 hours instructions for missed pills (see Figure) should be followed.
If taking antibiotics women should be advised to use condoms during antibiotic use and for 7 days after the antibiotic is stopped. If there are fewer
than 7 pills remaining in the packet the pill-free interval should be omitted. If a non-liver enzyme-inducing antibiotic has been used for ≥3 weeks
additional barrier contraception is no longer required.
When used consistently and correctly, COC is &gt;99% effective at preventing pregnancy. Missing pills is not encouraged but one pill can be missed
any time without loss of contraceptive protection. Instructions for missed pills are outlined in the Figure.
starting COC post-higher or same dose COC
The new combined oral contraceptive pill is started immediately. This is because of reports of rebound ovulation occurring at the time of tansfer. No extra contraceptive precautions are required for the first 7 days after transfer.
starting COC post-lower dose COC
The new preparation is started after the usual 7 day break, e.g. after completion of an every day packet of a combined oral contraceptive pill. No extra contraceptive precautions are required for the first 7 days of use of the new preparation
sudden severe chest pain (even if not radiating to left arm);
sudden breathlessness (or cough with blood-stained sputum);
unexplained swelling or severe pain in calf of one leg;
severe stomach pain;
serious neurological effects including unusual severe, prolonged headache especially if first time or getting progressively worse or sudden partial or complete loss of vision or sudden disturbance of hearing or other perceptual disorders or dysphasia or bad fainting attack or collapse or first unexplained epileptic seizure or weakness, motor disturbances, very marked numbness suddenly affecting one side or one part of body;
hepatitis, jaundice, liver enlargement;
blood pressure above systolic 160 mmHg or diastolic 95 mmHg;
prolonged immobility after surgery or leg injury;
detection of a risk factor which contra-indicates treatment (see Cautions and Contra-indications under Combined Hormonal Contraceptives below or under Oestrogens for HRT (section 6.4.1.1)).
This is a checklist in cases of possible breakthrough bleeding (BTB) occurring in COC takers. BTB bleeding may occur during the first few months after prescribing a new COC. If it persists then a cause must be sought.
History:taking of COC - ? missed pills ? taken at same time
medication - ? antibiotics ? enzyme inducers
history of gastroenteritis ?
is there a possibility of pregnancy or disorder associated with pregnancy e.g. trophoblastic tumour ?
factors affecting absorption of pill e.g. ileostomy ?
history of post-coital bleeding ? CIN ?
Examination: pelvic and speculum examination - swabs and cervical smear if indicated
If all possible causes have been excluded then the COC may be changed. Options include:
a user taking a monophasic pill may try a phasic pill
an increased level of progestogen
a different type of progestogen e.g. consider a 3rd generation COC
in some cases a high dose (50 mcg pill) may be considered
Case 1 – constructivism, authentic task, case-based learning
Case 2
Case 3
Practical tips
timing of changing pill
Summary - theory constuctivism repetition (Lockwood)
Ouctomes
Evaluation – learner – record what have learnt Reflection – schon
Separate paper / internet link
One thing like, one thing improve – appropriate space provided (Lockwood)
References/ sources/ further information
FFPRHC guidance (October 2003): First prescription of combined oral contraception. J Fam Plann Reprod Health Care 2003: 29(4): 209-223
http://www.gpnotebook.co.uk/simplepage.cfm?ID=x20040427100241089560&linkID=67538&cook=yes
Patient leafter http://www.patient.co.uk/showdoc/23068708/
Breakthrough bleeding for professionals http://www.patient.co.uk/showdoc/40025247/
Follow up consultation http://www.patient.co.uk/showdoc/40025029/
http://www.who.int/reproductive-health/publications/mec/mec_update_2008.pdf
Reproduction of above – different paper – to easily select.