Detail of Antianginal Agents

1. Antianginal Drugs

7. Types of Angina

8. Stable Angina
1) The experience is quite variable, often
described as chest pain & associated with
adjectives indicating a compressive
tightness.
2) Angina indicates that myocardial oxygen
demand is exceeding supply. “Stable”
indicates the reproducible nature of the
angina; the same activity at the same
intensity faithfully produces symptoms.
3) Typically this type of angina is relieved
by rest or acute use of nitroglycerin.

9. Unstable Angina
1) when anginal symptoms
occur with less cardiac
demand; previously
tolerated activities elicit
symptoms, of great
concern is angina at rest.
2) These episodes are less or
un-responsive to
nitroglycerine or rest.

10. Prinzmetal (Variant) Angina
1) uncommon pattern of myocardial ischemia
usually occurring at rest and often in young
individuals (particularly women)
2) The anginal attacks have a circadian rhythm
and generally occur in the early morning hours.
3) attacks can be triggered by alcohol, drinking
iced drinks, rapid eye movement sleep,
ergonovine, atrial pacing, cocaine, nicotine,
acetylcholine, and hyperventilation.
4) It is induced by coronary artery vasospasm it
generally responds promptly to vasodilators. It
is associated with other vasospastic disorders
such as migraine headaches and Raynaud’s
phenomena. Endothelial dysfunction has been
considered as primarily responsible for this.
5) The risk of both ventricular & bradyarrthymias
is markedly increased during spastic events,
sudden cardiac death is not uncommon.

12. Classes effective in treating angina:
1. Vasodilator or organic nitrates or nitro-vasodilator
Nitroglycerine
2. β-blockers – Propranolol
3. Ca+2
channel blockers- Verapamil, Diltiazem,
Nifedipine
4. Antithrombotic agent- Aspirin, Clopidrogel

13. Nitrovasodilator
stored in
endothelial cells
Metabolic
Transformation
in Vascular SM
Nitric oxide(No)
Guanylate cyclase
Activate
GTP C GMP
ProteinKinase
MLCKMLCK-PO4
(inactive)
Muscle Relax

14. Nitroglycerine is effective because:-
1) Redistribution of coronary blood flow to the ischemic
region
2) Decreased myocardial oxygen demand
3) Redistribution of blood causes pooling of blood in
Peripheral veins
4) decreased in ventricular volume, stroke volm.

15. Adverse effects:
1. The most common side effect of nitrates is headache due
to veno-dilation,
2. Postural hypotension
3. Tachycardia
4. Methemaglobinemia can occur with chronic use of long
term agents,
5. Withdrawal symptoms may occur (an indication of
tolerance) when nitrate agents are tapered or discontinued,
this may precipitate anginal attacks.

16. 1) Glyceryl Trinitrate (Nitroglycerin):- Trinitrin,Nitroglyn
PP:- 1) Clear colourless oily volatile liquid
2) Odourless but sweet in taste
3) Soluble in water , glycerol and freely
soluble in alcohol
Use’s:- 1) For treatment of Angina Pectoris
2) For unstable angina
3) To treat CHF
4) Post operative hypertension
Stability :- 1) Volatile in Nature & affected by
light.
Storage:- In a glass container with tightly fitting
metal screw cap
PPn:- 1) N.tablet-USP
2) N. Ointment-BPC

17. Reasons for Using Nitrates and Beta Blockers
in Combination in Angina
• Beta Blockers prevent reflex tachycardia and contractility
produced by nitrate-induced hypotension.
• Nitrates prevent any coronary vasospasm produced by
Beta Blockers.
• Nitrates prevent increases in left ventricular filling
pressure or preload resulting from the negative inotropic
effects produced by Beta Blockers.
• Nitrates and Beta Blockers both reduce myocardial oxygen
consumption by different mechanisms.
• Nitrates and Beta Blockers both increase subendocardial
blood flow by different mechanisms