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Treatment of Chronic Depression: Antidepressant Science Of Emotion: From Neurotransmitters to Social Networks

Treatment of Chronic Depression: Antidepressant v. CBT Study Week CBASP = cognitive behavioral-analysis system of psychotherapy; observed cases, LS means; NFZ = nefazodone. * P <.05 NFZ compared with CBASP; † P <.01 NFZ + CBASP compared with CBASP; ‡ P <.01 NFZ + CBASP compared with NFZ. No statistical difference between NFZ compared with NFZ + CBASP through week 4. ‡ Mean change in HAM-D scores: CBASP = -10.4; NFZ+CBASP = -16.6; NFZ = -11. Keller MB, et al. N Engl J Med. 2000;342:1462-1470. HAM-D Change From Baseline ‡ -20 -15 -10 -5 0 Baseline 1 2 3 4 6 8 10 12 CBASP NFZ + CBASP NFZ (max 600 mg/day) † † † * † ‡ ‡ ‡ ‡ † * † * † * †

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