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VISUAL FIELD EXAMINATION
AND
INTERPRETATION OF AUTOMATED
PERIMETRY IN GLAUCOMA
DR PAAVAN KALRA
DEPARTMENT OF OPHTHALMOLOGY
S P MEDICAL COLLEGE
BIKANER
VISUAL FIELD
• That part of environment wherein a steadily fixating eye can
detect visual stimulus.
• BASIS - presence of Photoreceptors and corresponding
visual pathways upto the periphery of retina away from point
of fixation i e fovea.
• IMPORTANCE – Reflects topographic sensitivity of various
foci on retina and corresponding visual apparatus.
Resolution – Acuity
differential light sensitivity and contrast
colour
flicker
motion
PHYSIOLOGICAL BASIS
VISUAL ACUITY
DIFFERENTIAL LIGHT SENSITIVITY
Basis of most modern visual field examination methods
TRAQUAIR – “HILL OF VISION IN THE SEA OF DARKNESS”
FACTORS
Apparent size of spot – real size
-- distance from eye
Duration of stimulus
Background illumination
Stimulus intensity
Contrast
Colour
Patient factors
Light / dark adaptation
Vision
Refractive status
Education , attentiveness, cooperation
Stereoscopic field
PHYSIOLOGICAL BLIND SPOT
Corresponding to optic nerve head
15 deg temporal to point of fixation
Span – 5 deg horizontal
-- 7 deg vertical
Two thirds below the horizontal
meridian
COLOUR FIELD
• Point at which passing from periphery to centre, the
colour first becomes evident
• Peripheral to the limit, the object is perceptible but
appears grey
• First red and green are used followed by blue and yellow
• Extent of field for objects of same size and intensity
white > yellow > blue > red > green
VISUAL FIELD DEFECTS
• SCOTOMA : focal region of abnormally decreased
sensitivity surrounded by an area of normal sensitivity
ABSOLUTE
RELATIVE
POSITIVE
NEGATIVE
• DEPRESSION : is an area of reduced sensitivity without
a surrounding area of normal sensitivity
appears as denting of isopters
• Generalized depression
(both peripheral and central contraction)
e g cataract
• Peripheral Contraction – retinitis pigmentosa
• Temporal contraction - age
• Hemifield defect :
B/L - Hemianopias
homonymous
heteronymous
• Altitudinal defect
• Central scotoma
• Pericentral
• Centrocaecal scotoma
• Arcuate scotomas
Seidel scotoma
paracentral scotoma
Bjerrum scotoma
• Nasal step
• Ring – double arcuate
• Split fixation
• Barring of blind spot
EXAMINATION METHODOLOGY
KINETIC
• Test object of particular size and intensity is passed from
non seeing area to seeing area along a particular
meridian at the rate of 3 – 5 deg per sec
• Repeated every 15 – 30 deg
• To find points in the visual field of equal sensitivities –
ISOPTER (Groenouw) marking
• Intensity and size of stimulus is varied to mark various
isopters
• Thus 2 D Contour map of the hill of vision is made
• Extent of scotomas and blind spot marked from inside
out
STATIC
• The location, size and duration of stimulus is kept constant
and the luminance is gradually increased until seen
• Actual estimation of sensitivity ( THRESHOLD ) of each
point is made out
• SUPRA THRESHOLD stimulus used for screening
-------------------------------------------------------------------------------
IMPORTANT :
one eye is tested at a time, other is occluded
fixation of the patient has to be steady and is
monitored throughout the test
---------------------------------------------------------------------------------
CLINICAL METHODS
GROSS DEFECTS
PROJECTION OF LIGHT
In patients with very poor vision –> HM + to PL +
e g dense cataracts
-dark room, other eye occluded
-patients are constantly instructed to look straight to avoid
tendency to deviate eye towards light source
-light shown onto 4 quadrants from 30-50 cm and switched
on and off
-Patient tells about the direction of light source
Accurate in all quad
Inaccurate in some quad
Inaccurate in all quad
HAND IDENTIFICATION
Other eye is occluded
Patient fixates on the nose of
examiner
Examiner keeps both hands on either
side of eye 50 cm away
One hand absent or indistinct –
hemianopic defect
Either palms or fingers of both hands
missing / faint – altitudinal defect
FINGER COUNTING
Varying no of fingers are held in each
quadrant, 1 m and 45 deg from
fixation
If unable to count, fingers are brought
closer to fixation, until patient sees
(kinetic)
RED DESATURATION
Can be confirmed kinetically
Patient has to indicate when color
appears to change
Can also be used to compare the
two eyes in case of optic
neuropathy
CONFRONTATION
(kinetic)
Patient‟s and examiner at same level
Compares the visual field of eye of
patient with opposite eye of the
examiner in a plane perpendicular
to line of gaze
Red pin is particularly useful for
neurological cases
GROSS PERIMETRY
(kinetic)
Follows facial contour
AMSLER GRID
For Central 10 deg ( static )
Other eye occluded
Near correction given
Chart at held 28-30 cm – each small square subtends angle of 1
deg
Patient fixates at central dot – tells whether all corners are seen
simultaneously and about lines- parallel, distorted, missing
Can be used for mapping blind spot – patient fixates at edge of
grid
EQUIPMENTS
PERIMETRY
Examination and quantification of visual
field by using stimulus of various
sizes, intensities and colours
ARC PERIMETERS
eg LISTER‟s PERIMETER
• Only kinetic
• Peripheral charting
BJERRUM’s SCREEN ( CAMPIMETRY)
• Patient sits at 1 or 2 m from flat screen
• Kinetic and static
• For central 30 deg only
• Done under subdued lighting
GOLDMANN’s PERIMETER
• Bowl type
• Standardization
• Both kinetic and static
• Peripheral as well as central
AUTOMATED PERIMETRY
standard automated perimetry
HUMPHREY FIELD ANALYZER
OCTOPUS
• STATIC perimetry
• Measurement of threshold values
• STATPAC (HFA)- Comparison to normative data
• Inbuilt program for analysis – diagnosis and progression
ADVANTAGES
• Removal of examiner variability
• More sensitive to subtle field defects
• Reproducibility
• Retests abnormal points automatically
• Gives reliability parameters like
fixation monitoring – HEIJL KRAKAU method
Gaze tracking
False positive
False negative
SHORT COMINGS
• EXPENSIVE
• Learning curves
• Difficult to follow by older debilitated patients especially
neurological problems
• Not infallible – only 1 % of field is actually examined
• Diagnosis and management decisions based on
correlation with other clinical findings
A well performed tangent screen examination is better than
poorly carried out automated perimetry
In neurological patients, clinical methods may be the only
possible assessment techniques
• WHITE ON WHITE
• BACKGROUND ILLUMINATION - 31.5 asb
• STIMULUS SIZE – GOLDMANN - III
• DURATION OF SPOT EXPOSURE 0.2s
PROGRAMS / PATTERNS
30-2 – gold standard
24-2
10-2
MACULAR
Nasal step program – additional 12 locations upto 50 deg nasal
peripheral 60 and 60-4 prog
Estermann test – for binocular 120 deg field
MACULA PROGRAM :16 locations
within the central 5° with 2° spacing.
Each location is tested three times
STRATEGIES
SUPRATHRESHOLD – screening
Fixed suprathreshold
contour suprathreshold
3 zone suprathreshold
FULL THRESHOLD
BRACKETING STRATEGY( staircase)
– GOLD STANDARD
FASTPAC
Estimation of SHORT TERM FLUCTATIONS at 10 prefixed points
SWEDISH INTERACTIVE TESTING ALGORITHM (SITA)
SITA STANDARD ( Bracketing strategy based)
SITA FAST ( FASTPAC based)
Analyzes patients response and responds accordingly
Decreases overall no of stimuli presented, hence test
duration
Paces the test according to patients speed
Doesn‟t estimate Short term Fluctuations
• Selection of adequate test
• Proper environment
• Comfortable sitting position
• Adequate size of pupil >3mm
• Adequate Near correction
• Proper explanation – running of demonstration
• Reassurance – not all points will be seen
- test can be paused by keeping the response
button pressed
Patient data
• Name, DOB, eye
• Vision, refraction,
• Pupil diameter
Test data
• Date and time
• Program and strategy
• Background
illumination
• Test
size, color, duration, i
nterval
ZONE 1 : REPRODUCIBILITY
ZONE 2 : RELIABILITY
• Fixation monitor
• Fixation target – central, small
diamond, large diamond, bottom LED
• Test duration
• Reliability indices
Fixation losses ( Heijl Krakau) <20 %
Gaze tracking
False positives < 33%
(trigger happy)
False negatives < 33 %
Foveal threshold
ZONE 3 : GREY SCALE
• Based on actual threshold values at each location
• General identification
• Patient information
ZONE 4 :TOTAL DEVIATION PLOT
• Numerical plot – indicates by how
much decibels is each point depressed
compared to mean value in normal
population of similar age
• Probability plot- grey scale indicates
the probability of occurrence of the
deviation in normal population
Generalized depression due to media
opacities, refractive error, miosis may
hamper appearance of a pattern
ZONE 5 : PATTERN DEVIATION
PLOT
• Numerical - calculated by adjustment for
generalized depression or elevation of
visual field
• Thus brings out pattern
• Probability plot
• Significance - ANDERSON‟S CRITERIA
ZONE 6 : GLOBAL INDICES
single numbers to denote whole field
• MEAN DEVIATION : average loss of sensitivity from
normal age matched population along with probability
calculated from total deviation plot
• PATTERN STANDARD DEVIATION : range over which
change of sensitivity at all the points has occurred, along
with probability
compensates for effect of generalized depression or
elevation of field on mean deviation value
local defects affect PSD > MD
• SHORT TERM FLUCTUATIONS
• CORRECTED PATTERN STANDARD DEVIATION
ZONE 7 : GLAUCOMA HEMIFIELD TEST
• PLAIN ENGLISH LANGUAGE MESSAGE
• Comparison of 5 clusters of points in
superior hemifield with mirror images in
inferior hemifield
OUTSIDE NORMAL LIMITS
all cluster pairs differ @ p < 1% OR
1 cluster pair differs @ p < 0.5%
BORDERLINE
hemifields differ @ p < 3%
GENERAL REDUCTION OF SENSITIVITY
overall field depressed @ p < 0.5%
ABNORMAL HIGH SENSITIVITY
overall field elevated( best 15 % points) @ p < 0.5 %
WITHIN NORMAL LIMITS
ANDERSON and PATELLA CRITERIA
• 3 or more congrous „non edge points‟ in typical arcuate area
on 30-2 program
depressed @ p< 5 % with at least one point @ p<1 %
•PSD / CPSD @ p< 5%
•GHT – outside normal limits
 Must be demonstrated on 2 field tests
CLINICAL CORRELATION : MUST
DISC and NERVE FIBRE LAYER
OVERVIEW
CHANGE ANALYSIS
GLAUCOMA PROGRESSION ANALYSIS
ARTEFACTS
• OBSTRUCTION
RIM ARTEFACTS
PTOSIS
MEDIA OPACITIES
ANGIOSCOTOMA
• MIOSIS
• REFRACTION ARTEFACTS
• High power plus and minus lenses
NEWER METHODS
SHORT WAVELENGTH AUTOMATED PERIMETERY
“BLUE ON YELLOW”
detects glaucomatous defects 3-5 years earlier than SAP
high fluctuation rates
FREQUENCY DOUBLING
PERIMETRY
Based on frequency doubling
illusion
Test stimulus – series of white
and black bands flickering at
25 Hz ( low spatial frequency
& high temporal frequncy)
Detects damage to
Magnocellular Ganglion cells
C – 20  17 points – screening
N – 30  19 points – diagnosis
n management
RANDOM DOT MOTION PERIMETRY
Patient has to tell direction in which dots are moving
HIGH PASS RESOLUTION PERIMETRY
Test resolution and not mere threshold detection
THANK YOU

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Visual Field Exam in Glaucoma

  • 1. VISUAL FIELD EXAMINATION AND INTERPRETATION OF AUTOMATED PERIMETRY IN GLAUCOMA DR PAAVAN KALRA DEPARTMENT OF OPHTHALMOLOGY S P MEDICAL COLLEGE BIKANER
  • 2. VISUAL FIELD • That part of environment wherein a steadily fixating eye can detect visual stimulus. • BASIS - presence of Photoreceptors and corresponding visual pathways upto the periphery of retina away from point of fixation i e fovea. • IMPORTANCE – Reflects topographic sensitivity of various foci on retina and corresponding visual apparatus. Resolution – Acuity differential light sensitivity and contrast colour flicker motion
  • 5. DIFFERENTIAL LIGHT SENSITIVITY Basis of most modern visual field examination methods TRAQUAIR – “HILL OF VISION IN THE SEA OF DARKNESS”
  • 6. FACTORS Apparent size of spot – real size -- distance from eye Duration of stimulus Background illumination Stimulus intensity Contrast Colour Patient factors Light / dark adaptation Vision Refractive status Education , attentiveness, cooperation
  • 8. PHYSIOLOGICAL BLIND SPOT Corresponding to optic nerve head 15 deg temporal to point of fixation Span – 5 deg horizontal -- 7 deg vertical Two thirds below the horizontal meridian
  • 9. COLOUR FIELD • Point at which passing from periphery to centre, the colour first becomes evident • Peripheral to the limit, the object is perceptible but appears grey • First red and green are used followed by blue and yellow • Extent of field for objects of same size and intensity white > yellow > blue > red > green
  • 11. • SCOTOMA : focal region of abnormally decreased sensitivity surrounded by an area of normal sensitivity ABSOLUTE RELATIVE POSITIVE NEGATIVE • DEPRESSION : is an area of reduced sensitivity without a surrounding area of normal sensitivity appears as denting of isopters
  • 12. • Generalized depression (both peripheral and central contraction) e g cataract • Peripheral Contraction – retinitis pigmentosa • Temporal contraction - age
  • 13. • Hemifield defect : B/L - Hemianopias homonymous heteronymous • Altitudinal defect
  • 14. • Central scotoma • Pericentral • Centrocaecal scotoma • Arcuate scotomas Seidel scotoma paracentral scotoma Bjerrum scotoma • Nasal step • Ring – double arcuate • Split fixation • Barring of blind spot
  • 15.
  • 17. KINETIC • Test object of particular size and intensity is passed from non seeing area to seeing area along a particular meridian at the rate of 3 – 5 deg per sec • Repeated every 15 – 30 deg • To find points in the visual field of equal sensitivities – ISOPTER (Groenouw) marking • Intensity and size of stimulus is varied to mark various isopters • Thus 2 D Contour map of the hill of vision is made • Extent of scotomas and blind spot marked from inside out
  • 18. STATIC • The location, size and duration of stimulus is kept constant and the luminance is gradually increased until seen • Actual estimation of sensitivity ( THRESHOLD ) of each point is made out • SUPRA THRESHOLD stimulus used for screening ------------------------------------------------------------------------------- IMPORTANT : one eye is tested at a time, other is occluded fixation of the patient has to be steady and is monitored throughout the test ---------------------------------------------------------------------------------
  • 20. PROJECTION OF LIGHT In patients with very poor vision –> HM + to PL + e g dense cataracts -dark room, other eye occluded -patients are constantly instructed to look straight to avoid tendency to deviate eye towards light source -light shown onto 4 quadrants from 30-50 cm and switched on and off -Patient tells about the direction of light source Accurate in all quad Inaccurate in some quad Inaccurate in all quad
  • 21. HAND IDENTIFICATION Other eye is occluded Patient fixates on the nose of examiner Examiner keeps both hands on either side of eye 50 cm away One hand absent or indistinct – hemianopic defect Either palms or fingers of both hands missing / faint – altitudinal defect
  • 22. FINGER COUNTING Varying no of fingers are held in each quadrant, 1 m and 45 deg from fixation If unable to count, fingers are brought closer to fixation, until patient sees (kinetic)
  • 23. RED DESATURATION Can be confirmed kinetically Patient has to indicate when color appears to change Can also be used to compare the two eyes in case of optic neuropathy
  • 24. CONFRONTATION (kinetic) Patient‟s and examiner at same level Compares the visual field of eye of patient with opposite eye of the examiner in a plane perpendicular to line of gaze Red pin is particularly useful for neurological cases GROSS PERIMETRY (kinetic) Follows facial contour
  • 25. AMSLER GRID For Central 10 deg ( static ) Other eye occluded Near correction given Chart at held 28-30 cm – each small square subtends angle of 1 deg Patient fixates at central dot – tells whether all corners are seen simultaneously and about lines- parallel, distorted, missing Can be used for mapping blind spot – patient fixates at edge of grid
  • 27. PERIMETRY Examination and quantification of visual field by using stimulus of various sizes, intensities and colours
  • 28. ARC PERIMETERS eg LISTER‟s PERIMETER • Only kinetic • Peripheral charting
  • 29. BJERRUM’s SCREEN ( CAMPIMETRY) • Patient sits at 1 or 2 m from flat screen • Kinetic and static • For central 30 deg only • Done under subdued lighting
  • 30. GOLDMANN’s PERIMETER • Bowl type • Standardization • Both kinetic and static • Peripheral as well as central
  • 31. AUTOMATED PERIMETRY standard automated perimetry HUMPHREY FIELD ANALYZER OCTOPUS • STATIC perimetry • Measurement of threshold values • STATPAC (HFA)- Comparison to normative data • Inbuilt program for analysis – diagnosis and progression
  • 32. ADVANTAGES • Removal of examiner variability • More sensitive to subtle field defects • Reproducibility • Retests abnormal points automatically • Gives reliability parameters like fixation monitoring – HEIJL KRAKAU method Gaze tracking False positive False negative
  • 33. SHORT COMINGS • EXPENSIVE • Learning curves • Difficult to follow by older debilitated patients especially neurological problems • Not infallible – only 1 % of field is actually examined • Diagnosis and management decisions based on correlation with other clinical findings A well performed tangent screen examination is better than poorly carried out automated perimetry In neurological patients, clinical methods may be the only possible assessment techniques
  • 34. • WHITE ON WHITE • BACKGROUND ILLUMINATION - 31.5 asb • STIMULUS SIZE – GOLDMANN - III • DURATION OF SPOT EXPOSURE 0.2s
  • 35. PROGRAMS / PATTERNS 30-2 – gold standard 24-2 10-2 MACULAR Nasal step program – additional 12 locations upto 50 deg nasal peripheral 60 and 60-4 prog Estermann test – for binocular 120 deg field
  • 36.
  • 37. MACULA PROGRAM :16 locations within the central 5° with 2° spacing. Each location is tested three times
  • 38. STRATEGIES SUPRATHRESHOLD – screening Fixed suprathreshold contour suprathreshold 3 zone suprathreshold
  • 39. FULL THRESHOLD BRACKETING STRATEGY( staircase) – GOLD STANDARD FASTPAC Estimation of SHORT TERM FLUCTATIONS at 10 prefixed points
  • 40. SWEDISH INTERACTIVE TESTING ALGORITHM (SITA) SITA STANDARD ( Bracketing strategy based) SITA FAST ( FASTPAC based) Analyzes patients response and responds accordingly Decreases overall no of stimuli presented, hence test duration Paces the test according to patients speed Doesn‟t estimate Short term Fluctuations
  • 41. • Selection of adequate test • Proper environment • Comfortable sitting position • Adequate size of pupil >3mm • Adequate Near correction • Proper explanation – running of demonstration • Reassurance – not all points will be seen - test can be paused by keeping the response button pressed
  • 42.
  • 43. Patient data • Name, DOB, eye • Vision, refraction, • Pupil diameter Test data • Date and time • Program and strategy • Background illumination • Test size, color, duration, i nterval ZONE 1 : REPRODUCIBILITY
  • 44. ZONE 2 : RELIABILITY • Fixation monitor • Fixation target – central, small diamond, large diamond, bottom LED • Test duration • Reliability indices Fixation losses ( Heijl Krakau) <20 % Gaze tracking False positives < 33% (trigger happy) False negatives < 33 % Foveal threshold
  • 45.
  • 46. ZONE 3 : GREY SCALE • Based on actual threshold values at each location • General identification • Patient information
  • 47. ZONE 4 :TOTAL DEVIATION PLOT • Numerical plot – indicates by how much decibels is each point depressed compared to mean value in normal population of similar age • Probability plot- grey scale indicates the probability of occurrence of the deviation in normal population Generalized depression due to media opacities, refractive error, miosis may hamper appearance of a pattern
  • 48. ZONE 5 : PATTERN DEVIATION PLOT • Numerical - calculated by adjustment for generalized depression or elevation of visual field • Thus brings out pattern • Probability plot • Significance - ANDERSON‟S CRITERIA
  • 49. ZONE 6 : GLOBAL INDICES single numbers to denote whole field • MEAN DEVIATION : average loss of sensitivity from normal age matched population along with probability calculated from total deviation plot • PATTERN STANDARD DEVIATION : range over which change of sensitivity at all the points has occurred, along with probability compensates for effect of generalized depression or elevation of field on mean deviation value local defects affect PSD > MD • SHORT TERM FLUCTUATIONS • CORRECTED PATTERN STANDARD DEVIATION
  • 50. ZONE 7 : GLAUCOMA HEMIFIELD TEST • PLAIN ENGLISH LANGUAGE MESSAGE • Comparison of 5 clusters of points in superior hemifield with mirror images in inferior hemifield
  • 51. OUTSIDE NORMAL LIMITS all cluster pairs differ @ p < 1% OR 1 cluster pair differs @ p < 0.5% BORDERLINE hemifields differ @ p < 3% GENERAL REDUCTION OF SENSITIVITY overall field depressed @ p < 0.5% ABNORMAL HIGH SENSITIVITY overall field elevated( best 15 % points) @ p < 0.5 % WITHIN NORMAL LIMITS
  • 52. ANDERSON and PATELLA CRITERIA • 3 or more congrous „non edge points‟ in typical arcuate area on 30-2 program depressed @ p< 5 % with at least one point @ p<1 % •PSD / CPSD @ p< 5% •GHT – outside normal limits  Must be demonstrated on 2 field tests
  • 53. CLINICAL CORRELATION : MUST DISC and NERVE FIBRE LAYER
  • 57. ARTEFACTS • OBSTRUCTION RIM ARTEFACTS PTOSIS MEDIA OPACITIES ANGIOSCOTOMA • MIOSIS • REFRACTION ARTEFACTS • High power plus and minus lenses
  • 58.
  • 59.
  • 60.
  • 61.
  • 63. SHORT WAVELENGTH AUTOMATED PERIMETERY “BLUE ON YELLOW” detects glaucomatous defects 3-5 years earlier than SAP high fluctuation rates
  • 64. FREQUENCY DOUBLING PERIMETRY Based on frequency doubling illusion Test stimulus – series of white and black bands flickering at 25 Hz ( low spatial frequency & high temporal frequncy) Detects damage to Magnocellular Ganglion cells C – 20  17 points – screening N – 30  19 points – diagnosis n management
  • 65. RANDOM DOT MOTION PERIMETRY Patient has to tell direction in which dots are moving HIGH PASS RESOLUTION PERIMETRY Test resolution and not mere threshold detection