Genetic Engineering[1]

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What is Genetic Engineering? Genetic Engineering – technology of altering the genes of an organism to produce a desired change.

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Introduction. Definition. Importance of transgenic animals. Transgenic mice Methods for introducing a foreign gene: The retroviral vector method The DNA microinjection method/ pronuclear microinjection Genetically engineered embryonic stem cells Transgenic fish What is transgenic fish? A few facts to know to know about transgenic fish. Important points needed for genetic engineering (gene transfer) to produce transgenic fish. Development of transgenic fishes. A few examples Auto-transgenesis. Controlled culture of transgenic fish and feed. Gene transfer technology for development of transgenic fishes. Gene flow. Food safety issues. Conclusion. Bibliography.

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The renin–angiotensin system (RAS) is a hormone system that regulates blood pressure and fluid balance. renin–angiotensin system (RAS) is developed in animal by transgenic technology and effects of vasoactive peptide are seen. Vasoactive peptide is a peptide hormone containing 28 amino acid residues. Vasoactive peptide is produced in many tissues including the gut, pancreas, and suprachiasmatic nuclei of the hypothalamus in the brain. It stimulates contractility of heart, causes vasodilation, lowers arterial blood pressure. Vasoactive peptide has a half-life (t½) in the blood of about two minutes. Transgenic technology has established to be very useful for the functional analysis of vasoactive peptide systems.

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