3. What is Pharmacodynamics
Drug response curve
EC50
Potency
Efficacy
Refrences
4. Pharmacodynacmics describes the
action of drug on body and influence
of drug concentration on magnitude
of response
Most of drugs exerts effect by
ineracting with receptor
An agent that can bind to recepor and
produces iological rsponse is called as
agonist
5. The interaction between drug and its
receptor can be described by a curve
called as drug response curve
on Vertical axix there is response of drug
On horizontal axix there is concentration
of dose
6. The magnitude of drug effect
depends on drug concentration at
receptor site and this availbilty and
concentration of drug at receptor is
determined by both dose of drug
administered and by drug
pharmacokinetics(ADME)
7. When no drug is added then no effect is
produced
12. Two important properties of drug can be found
by dose reponse curve
Efficacy
Potency
PotencyPotency
amount of drug necessary to produce
maximum effect is the potecncy of drug
13. Candesartan and ibesartan are
angiotensin receptor blocker
Candesartan is more potent then
Ibesartan because the dose range for
candesartan is 4 to 32 mg as compared to
dose range of ibesartan whose dose
range is 25 to 300 mg
14.
15. Ability of a drug to elicit a response when it
interacts with a receptor
Efficacy is dependent on;
the number of drug-receptor complexes formed
efficiency of the coupling of receptor activation to cellular
responses.
Maximal efficacy of a drug assumes that all receptors
are occupied by the drug and if more drugs are
added, no additive response will be observed.
Maximal response (efficacy) is more important than
drug potency.
A drug with greater efficacy is more therapeutically
beneficial than the one that is more potent.