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Helena Deus: The Protein Regulatory Networks of Covid-19

In this webinar, Helena Deus talks about the COVID-19 knowledge graph that Elsevier created by applying text mining techniques on relevant papers. She also discusses why a knowledge graph was used.

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Helena Deus: The Protein Regulatory Networks of Covid-19

  1. 1. THE PROTEIN REGULATORY NETWORKS OF COVID-19
  2. 2. THE PROTEIN REGULATORY NETWORKS OF COVID-19 WHAT SCIENTISTS NEED TO WORK ON DURING A PANDEMIC? 1. Drug repurpose / Vaccine repurpose 1. Find FDA approved drugs /medicines (already shown to be safe) 2. Identify which drugs bind to proteins used by the virus 2. Scale up testing 1. Most hospitals use only one testing facility, which can quickly get overwhelmed 2. Carry out antibody tests and contact tracing 3. Reliable information 1. Doctors sharing and trusting information shared on social media faster than preprints available 2. Policy makers need help understanding the spread in order to control it
  3. 3. SCALING UP VACCINES AND TREATMENTS https://www.av.co/covid THE PROTEIN REGULATORY NETWORKS OF COVID-19
  4. 4. SCALING UP VACCINES AND TREATMENTS https://www.av.co/covid THE PROTEIN REGULATORY NETWORKS OF COVID-19
  5. 5. DEEP DIVE INTO THE BIOLOGY OF COVID-19
  6. 6. COVID-19 – The name of the disease Sars-Cov-2 or 2019-nCoV (old) – The virus itself Coronavirus – The class of virus that Sars- Cov-2 belong to (MERS and SARS also caused by coronavirus THE PROTEIN REGULATORY NETWORKS OF COVID-19 WHAT IS COVID-19 AND SARS-COV-2?
  7. 7. THE CORONAVIRUS IS VERY MUCH LIKE A COMPUTER VIRUS Operating System Files Root Access Antivirus Firewall Malicious Rootkit DNA Skin Coronavirus virus making machine Ability to make millions of copies! Immune system Cell Membrane THE PROTEIN REGULATORY NETWORKS OF COVID-19
  8. 8. THE PROTEIN REGULATORY NETWORKS OF COVID-19 https://www.visualcapitalist.com/visualizing-what-covid-19-does-to-your-body/
  9. 9. INNATE VS ADAPTIVE IMMUNE SYSTEM THE PROTEIN REGULATORY NETWORKS OF COVID-19
  10. 10. HOW SARS-COV-2 ENTERS THE CELL THE PROTEIN REGULATORY NETWORKS OF COVID-19 https://www.antibodies-online.com/
  11. 11. QUERYING THE COVID-19 KNOWLEDGE GRAPH https://b14bf0da.databases.neo4j.io/browser/ username: elsevier password: 3153v13ruser
  12. 12. MATCH A LIST OF DRUGS
  13. 13. EXPLODE’ ONE OF THE DRUGS
  14. 14. FIND OUT WHICH DRUGS DOWN REGULATE ACE2
  15. 15. LEARN MORE ABOUT THE PROTEIN VIA KEGG
  16. 16. CAN WE COMPENSATE WITH MAS1?
  17. 17. LEARN MORE ABOUT N-ACETYLCYSTEINE
  18. 18. THANK YOU!

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