Is Suspended Animation only in the realms of science fiction, or is this a realsitic treatment option? Mervyn Singer questions if we can prevent secondary reperfusion injury following cerbral ischaemia.
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Suspended Animation by Mervyn Singer
1. Suspended animation:
science fiction or plausible therapy?
Mervyn Singer
Bloomsbury Institute of
Intensive Care Medicine
University College London, UK
11. haemorrhagic shock in rats
MAP 40 mmHg for 90’ .. then resusc’n
After 15’ shock randomized to:
normothermia (38°C)
brief hypothermia (34°C) for 15-90’
during shock + 30’ after reperfusion
prolonged hypothermia (as brief, then
35°C from 30’ to 12h)
17. natural daily torpor in mice
torpor induced by lowering
core temperature to 16C
and food deprivation in mice
torpor induced by injecting
5-AMP i.p. into mice
29. Drug given on resuscitation, 90 minutes after 50% haemorrhage
MGC-0109 in whole-body haemorrhage-reperfusion injury
placebo
MLS-001
30. Drug given on resuscitation, 90 minutes after 50% haemorrhage
MGC-0109 in whole-body haemorrhage-reperfusion injury
Core temperature Heart rate Protein carbonyls (2h) IL-6 (2h)
placebo
MGS-0109
Time post-resuscitation (h) 2h post-resuscitation
31. Myocardial ischaemia-reperfusion injury
Long-term myocardial damage:
Ischaemia/infarction from coronary artery occlusion
Reperfusion injury from PCI
0
10
20
30
40
TTM control
%infarct
area at risk
MGC-0109
33. Write lots of grants
Find a drug company to fund trials
Find a billionaire
Potential utility -> practical reality
34. sulphide inhibits mitochondrial respiration and metabolism
other useful effects, e.g. anti-inflammatory
potential utility for use in ischaemia-reperfusion injury states
human volunteer trials to start 2016 - watch this space!
Conclusion