5. What is the Compelling Opportunity
in Medicine?
6. Healthcare: The Need for Transformation
• Total health care spending was $2.5 trillion in 2009,
representing ~17.6% of the GDP, likely to reach $4 trillion by
2016
• 75-90% were spent on managing and treating chronic illnesses
that are preventable and effectively managed
• On a per-person basis, our health care costs are 50% higher
than the second most costly nation.
• IOM reports that up to 98,000 preventable deaths occur per
year and the research to practice gap is 17 years.
• The U.S. healthcare ranked by the WHO 37/191 countries in
performance.
• Drugs prescribed for patients are effective in fewer than 60% of
treated patients but costs of development is skyrocketed.
9. Francis Collins NIH Vision
• Large Biology Projects with
High Throughput
Technologies
• Translational Research
• Global Health
• Health Care Reform
• Sustaining Biomedical
Research
10. Disruptive Innovation to Transform Health
Care
• Create precision medicine
(personalized care)
• Push care from more specialized to
less specialized providers using rules-
based approaches
• Decentralize medical care (push to
community)
• Integrate medical information
• Incentivize health from integrated
organizations that will benefit from
health of its members (like Ohio
State)
24. Medical Center Strategic Portfolio
Personalized Health Care
Education
Signature Programs
Research
Innovation and Academic excellence
Transplantation
Neurosciences
Critical Care
intellectual impact and knowledge
Imaging
Cancer
Heart
Key Research Programs
Human Genetics
Creating the future Biomedical Informatics
of medicine to Behavioral Medicine
improve people’s Patient Care
lives
Clinical Excellence and Service
Delivery
29. Predictive Using a person’s genetic
makeup and family history to
Preventive generate predictions about
his or her health
Personalized
Participatory
29
30. Diane Balster
• Genetic testing
revealed BRCA2
mutation
• Chose preventive
procedures to
minimize her risk
• Predictive care at
Ohio State gives
people the
knowledge they
need to make
informed decisions
30
31. Predictive Using a person’s health-
related information to
Preventive prevent disease before it
starts
Personalized
Participatory
31
32. Medical Genetics at Ohio State
• Hereditary Heart
Rhythm Disorders
Clinic
• High Risk Family
Heart Clinic
• Clinical Cancer
Genetics Program
• Coriell Personalized
Medicine
Collaborative
• Heather Hampel,
genetics counselor
and ABGC president Heather Hampel, MS, CGC
32
33. Predictive Customizing medical care to
the individual patient
Preventive
Personalized
Participatory
33
34. Janet Graves
• Routine test
revealed
hypertrophic
cardiomyopathy
• Chose to treat
condition with
implantable
cardiac
defibrillator
• Extended family
undergoing
genetic testing
34
35. Predictive Encouraging patients to
actively participate in their
Preventive personal choices about
illness and well-being
Personalized
Participatory
35
36. Rita Brosie
• Chose Ohio State
for her bariatric
surgery
• Ohio State is a
Bariatric Surgery
Center of
Excellence
• Rita’s participation
in her own care
plan is key to her
continued success
36
37. Your Plan for Health
• Faculty and staff
YP4H
wellness program
at Ohio State
• Provides tools and
programs that help
faculty and staff and
their families take a
proactive approach to
their health
• Incentivizes healthy
behaviors
37
38. OSUMyChart
• Provides secure
online access to
patient information
and health services
• IHIS: a single,
electronic,
personalized health
record for the entire
Medical Center
• Improves the quality,
safety and efficiency
of our care.
38
39. P4 Medicine in Medical Curriculum
• Curriculum restructure
prepares future doctors to
practice P4 Medicine
• Greater focus on predictive
medicine and preventive
health care
• Use of mobile devices like
iPod touch at the bedside
promotes participatory
medicine
• Clinical Skills Education and
Assessment Center
Catherine Lucey, MD
expansion helps prevent
medical complications 39
43. Defining and Quantifying Health
Health is a state of complete physical,
mental, and social well-being and not Behavior
merely the absence of disease or
infirmity.
-- WHO, 1948 Environment
Health is the ever-changing process of
achieving individual potential in the
physical, emotional, social, mental, Genetics
spiritual, and environmental
dimensions.
-- Bridget Melton, 2010
Physical
44. Dimensions for Measuring Health
• Optimism
• Faith/Spiritual
• Relationship: family and
Behavior
social network
• Empathy
• Social functioning
Environment • Lifestyles
Genetics
Physical
46. Dimensions for Measuring Health
Behavior
Environment
• Family health history
• Genetic test (SNPs)
• Pharmacogenomics test
Genetics • DNA sequences and epigenetics
• Transcriptomics
• Targeted genetic screening
• Network analysis (systems and
Physical computational biology)
47. Dimensions for Measuring Health
Behavior
Environment
Genetics • Biometrics
• Autonomic nervous system
• Grip /core strengths
• Balance
Physical • Endurance
• Cognitive functioning
• Bio markers
50. Two Main Pilot Projects: Wellness and
Care Coordination in Chronic Disease
wellness.ucsd.edu/WhatisWellness.shtml kardiol.com/?tag=heart-failure
51. P4 Approach to Wellness
Longitudinal Optional special and/or virtual clinics that meet individual needs
PHA/Biomarker data leads
to Care Team review and Molecular Diagnostics • Biomarker and Genetic risk factor
recommendations Genetic Counseling awareness and education
• Behavioral risk factor awareness
and mitigation strategies;
Your Strategic Plan For Behavioral Health happiness, optimism
Health
• Sleep medicine and circadian
Sleep Medicine & rhythm analysis
Circadian Rhythm • Assist individuals for best rest to
Customer visit medical home promote health
team and/or family physician
to review and finalize plan: • Evidence-based
• Current strengths and Nutrition recommendations
weaknesses • Nutrition and diet changes that
• Opportunities for meet each person’s unique needs
improvement
• Health and wellness targets for
• Exercise and physical
next 2, 5, and 10 years Exercise & performance performance routines designed
• Action Plan: recommendations for individual needs
53. Principles of Transforming Health Care
• Reduce variability and deliver evidence-based
medicine (Personalize)
• Stratify patients to create smaller, precise
groups (Predict, Prevent, Personalize)
• Analyze data to create knowledge (Predict,
Prevent, Personalize)
• Activate patients (Participation)
66. The Power of Networks
• 500 M users
– 50% on line at any
one time
• 700 B minutes a
month
• 177 M tweets/day
• 572K new accts/day
jeichert.wordpress.com
67. You Tube is the 2nd Most Used Search
Engine on the Internet
68. 1 in 75 People on the Planet is Playing
Farmville
www.slideshare.net/avantgame/born-to-play-games-a-talk-by-
jane-mcgonigal-about-human-destiny-circa-2020-ad
75. Social Media and Smoking Cessation
http://www.euroclinix.net/health-news/smoking- www.health.com/.../0,,20209135,00.html
cessation/facebook-helping-people-to-kick-the-habit-231.html
76.
77. Personalized Medicine Home
Dedicated
PCP or NP
Assigned
Telemed tools Care
Coordinator
Visits, Lab- Patient
Test, and tracking
Referral and registry
tracking functions
Patient self-
management
support
78. Be the Change That You Want to See in
the World
Mahatma Gandhi