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“It is not the fittest of the species that
 survives, it is the most adaptable to
                  change”

            Charles Darwin
bordalierinstitute.com
meta-activism.org
What is the Compelling Opportunity
           in Medicine?
Healthcare: The Need for Transformation
• Total health care spending was $2.5 trillion in 2009,
  representing ~17.6% of the GDP, likely to reach $4 trillion by
  2016
• 75-90% were spent on managing and treating chronic illnesses
  that are preventable and effectively managed
• On a per-person basis, our health care costs are 50% higher
  than the second most costly nation.
• IOM reports that up to 98,000 preventable deaths occur per
  year and the research to practice gap is 17 years.
• The U.S. healthcare ranked by the WHO 37/191 countries in
  performance.
• Drugs prescribed for patients are effective in fewer than 60% of
  treated patients but costs of development is skyrocketed.
Blue Ocean Strategy

          Value Innovation
                   Costs




                    Value
                 Innovation




                Buyer Value
What is the External Landscape?
Francis Collins NIH Vision
• Large Biology Projects with
  High Throughput
  Technologies
• Translational Research
• Global Health
• Health Care Reform
• Sustaining Biomedical
  Research
Disruptive Innovation to Transform Health
                    Care
• Create precision medicine
  (personalized care)
• Push care from more specialized to
  less specialized providers using rules-
  based approaches
• Decentralize medical care (push to
  community)
• Integrate medical information
• Incentivize health from integrated
  organizations that will benefit from
  health of its members (like Ohio
  State)
What Do Health, Disease and Nature
       Share in Common?
freelancingscience.com
freelancingscience.com
forums.treehugger.com
http://education.mit.edu/starlogo-tng/learn/flocking-activity
www.bioteams.com/images/swarm_behavior.jpg
corpusoptima.com

   corpusoptima.com
engineering.tufts.edu
unreasonablydangerousonionrings.blogspot.com
They are Complex Adaptive Systems
       Made up of Networks
What Else Works in Networks?
clickonf5.org
The Tipping Point and Social Networks




                             www.flickr.com
NEJM 2007 (357): 406-07
Almost Everything
Medical Center Strategic Portfolio

                                      Personalized Health Care




                                                                                                                   Education
                                              Signature Programs



                      Research
  Innovation and                                                                                                               Academic excellence




                                                                                                 Transplantation
                                                                                 Neurosciences
                                               Critical Care
intellectual impact                                                                                                              and knowledge




                                                                       Imaging
                                    Cancer



                                                               Heart
                                       Key Research Programs
                                                Human Genetics
 Creating the future                         Biomedical Informatics
   of medicine to                             Behavioral Medicine
  improve people’s                                     Patient Care
        lives
                                 Clinical Excellence and Service
                                             Delivery
Personalized Health Care is P4/Systems Medicine
Wellness from the Individual to the World




    Resilience      To       Sustainability
P4 Medicine
     Partnerships




28
Predictive     Using a person’s genetic
                     makeup and family history to
      Preventive     generate predictions about
                     his or her health
     Personalized
     Participatory




29
Diane Balster
• Genetic testing
  revealed BRCA2
  mutation
• Chose preventive
  procedures to
  minimize her risk
• Predictive care at
  Ohio State gives
  people the
  knowledge they
  need to make
  informed decisions

                             30
Predictive     Using a person’s health-
                     related information to
      Preventive     prevent disease before it
                     starts
     Personalized
     Participatory




31
Medical Genetics at Ohio State
• Hereditary Heart
  Rhythm Disorders
  Clinic
• High Risk Family
  Heart Clinic
• Clinical Cancer
  Genetics Program
• Coriell Personalized
  Medicine
  Collaborative
• Heather Hampel,
  genetics counselor
  and ABGC president     Heather Hampel, MS, CGC
                                                   32
Predictive     Customizing medical care to
                     the individual patient
      Preventive
     Personalized
     Participatory




33
Janet Graves
• Routine test
  revealed
  hypertrophic
  cardiomyopathy
• Chose to treat
  condition with
  implantable
  cardiac
  defibrillator
• Extended family
  undergoing
  genetic testing
                          34
Predictive     Encouraging patients to
                     actively participate in their
      Preventive     personal choices about
                     illness and well-being
     Personalized
     Participatory




35
Rita Brosie
• Chose Ohio State
  for her bariatric
  surgery
• Ohio State is a
  Bariatric Surgery
  Center of
  Excellence
• Rita’s participation
  in her own care
  plan is key to her
  continued success
                              36
Your Plan for Health
 • Faculty and staff
                           YP4H
   wellness program
   at Ohio State
 • Provides tools and
   programs that help
   faculty and staff and
   their families take a
   proactive approach to
   their health
 • Incentivizes healthy
   behaviors

                             37
OSUMyChart
• Provides secure
  online access to
  patient information
  and health services
• IHIS: a single,
  electronic,
  personalized health
  record for the entire
  Medical Center
• Improves the quality,
  safety and efficiency
  of our care.

                          38
P4 Medicine in Medical Curriculum
• Curriculum restructure
  prepares future doctors to
  practice P4 Medicine
• Greater focus on predictive
  medicine and preventive
  health care
• Use of mobile devices like
  iPod touch at the bedside
  promotes participatory
  medicine
• Clinical Skills Education and
  Assessment Center
                                  Catherine Lucey, MD
  expansion helps prevent
  medical complications                                 39
P4 Medicine: Disease to Wellness

 How Do We Define Wellness?
Your Environment Regulates DNA Activity
Behavior   Environment   Gene
Defining and Quantifying Health

Health is a state of complete physical,
mental, and social well-being and not      Behavior
merely the absence of disease or
infirmity.
-- WHO, 1948                              Environment
Health is the ever-changing process of
achieving individual potential in the
physical, emotional, social, mental,       Genetics
spiritual, and environmental
dimensions.
-- Bridget Melton, 2010
                                            Physical
Dimensions for Measuring Health
                 • Optimism
                 • Faith/Spiritual
                 • Relationship: family and
  Behavior
                   social network
                 • Empathy
                 • Social functioning
 Environment     • Lifestyles



  Genetics



   Physical
Dimensions for Measuring Health


  Behavior
                 •   Diet / Nutrition
                 •   Sleep / biorhythm
                 •   Micro-biomes
 Environment     •   Geo-locations
                 •   Employment / workplace
                 •   Culture

  Genetics



   Physical
Dimensions for Measuring Health


  Behavior


 Environment
                 •   Family health history
                 •   Genetic test (SNPs)
                 •   Pharmacogenomics test
  Genetics       •   DNA sequences and epigenetics
                 •   Transcriptomics
                 •   Targeted genetic screening
                 •   Network analysis (systems and
   Physical          computational biology)
Dimensions for Measuring Health


  Behavior


 Environment



  Genetics       •   Biometrics
                 •   Autonomic nervous system
                 •   Grip /core strengths
                 •   Balance
   Physical      •   Endurance
                 •   Cognitive functioning
                 •   Bio markers
Program at OSUMC
Two Main Pilot Projects: Wellness and
Care Coordination in Chronic Disease




   wellness.ucsd.edu/WhatisWellness.shtml   kardiol.com/?tag=heart-failure
P4 Approach to Wellness

          Longitudinal              Optional special and/or virtual clinics that meet individual needs
   PHA/Biomarker data leads
   to Care Team review and           Molecular Diagnostics           •   Biomarker and Genetic risk factor
       recommendations                Genetic Counseling                 awareness and education

                                                                     •   Behavioral risk factor awareness
                                                                         and mitigation strategies;
   Your Strategic Plan For             Behavioral Health                 happiness, optimism
           Health
                                                                     •   Sleep medicine and circadian
                                       Sleep Medicine &                  rhythm analysis
                                       Circadian Rhythm              •   Assist individuals for best rest to
Customer visit medical home                                              promote health
   team and/or family physician
   to review and finalize plan:                                      •   Evidence-based
• Current strengths and                    Nutrition                     recommendations
   weaknesses                                                        •   Nutrition and diet changes that
• Opportunities for                                                      meet each person’s unique needs
   improvement
• Health and wellness targets for
                                                                     •   Exercise and physical
   next 2, 5, and 10 years          Exercise & performance               performance routines designed
• Action Plan: recommendations                                           for individual needs
Chronic Disease




Identify                    Stratify                                    Prevent/Treat




acl.com    www.indezine.com/.../peopleanimation_02.jpg   www.socialsecurityinsider.com/wp-content/uplo
Principles of Transforming Health Care

• Reduce variability and deliver evidence-based
  medicine (Personalize)
• Stratify patients to create smaller, precise
  groups (Predict, Prevent, Personalize)
• Analyze data to create knowledge (Predict,
  Prevent, Personalize)
• Activate patients (Participation)
Reduce Variability to Decrease Cost
      and Increase Quality
Stratify Populations
Single Nucleotide Polymorphisms in
  Clinical Medicine: Pharmacogenomics




                       Pharmacogenomics


science.marshall.edu                      pharmainfo.net
Analyze Data to Create Knowledge
http://www.sys-bio.org/contentimages/WhyWeNeedComputer.png
Hubs are Strong Links in Networks
Group Working on Complex Adaptive
Systems and Networks in Health Care
Identify Networks and Key Regulatory Nodes
            Controlling Networks




        http://mcdb.colorado.edu/courses/3280/lectures/class16-2.html
Engage Consumers
Participatory Medicine




ama-assn.org
The Power of Networks

           • 500 M users
             – 50% on line at any
               one time
           • 700 B minutes a
             month

           • 177 M tweets/day
           • 572K new accts/day

                           jeichert.wordpress.com
You Tube is the 2nd Most Used Search
       Engine on the Internet
1 in 75 People on the Planet is Playing
              Farmville




           www.slideshare.net/avantgame/born-to-play-games-a-talk-by-
           jane-mcgonigal-about-human-destiny-circa-2020-ad
Networks, Participation, the Power of
    Games and Crowdsourcing
Jane McGonigal and Games
Finding the Red Balloon




                          techcrunch.com
What Are Health Applications?
bryankorourke.com
Social Media and Smoking Cessation




        http://www.euroclinix.net/health-news/smoking-          www.health.com/.../0,,20209135,00.html
 cessation/facebook-helping-people-to-kick-the-habit-231.html
Personalized Medicine Home

                     Dedicated
                     PCP or NP

                                     Assigned
    Telemed tools                      Care
                                    Coordinator




     Visits, Lab-                      Patient
      Test, and                       tracking
       Referral                     and registry
      tracking                       functions
                    Patient self-
                    management
                      support
Be the Change That You Want to See in
             the World

                        Mahatma Gandhi

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P4 Medicine Town Meeting

  • 1.
  • 2. “It is not the fittest of the species that survives, it is the most adaptable to change” Charles Darwin
  • 5. What is the Compelling Opportunity in Medicine?
  • 6. Healthcare: The Need for Transformation • Total health care spending was $2.5 trillion in 2009, representing ~17.6% of the GDP, likely to reach $4 trillion by 2016 • 75-90% were spent on managing and treating chronic illnesses that are preventable and effectively managed • On a per-person basis, our health care costs are 50% higher than the second most costly nation. • IOM reports that up to 98,000 preventable deaths occur per year and the research to practice gap is 17 years. • The U.S. healthcare ranked by the WHO 37/191 countries in performance. • Drugs prescribed for patients are effective in fewer than 60% of treated patients but costs of development is skyrocketed.
  • 7. Blue Ocean Strategy Value Innovation Costs Value Innovation Buyer Value
  • 8. What is the External Landscape?
  • 9. Francis Collins NIH Vision • Large Biology Projects with High Throughput Technologies • Translational Research • Global Health • Health Care Reform • Sustaining Biomedical Research
  • 10. Disruptive Innovation to Transform Health Care • Create precision medicine (personalized care) • Push care from more specialized to less specialized providers using rules- based approaches • Decentralize medical care (push to community) • Integrate medical information • Incentivize health from integrated organizations that will benefit from health of its members (like Ohio State)
  • 11. What Do Health, Disease and Nature Share in Common?
  • 16. corpusoptima.com corpusoptima.com
  • 18. They are Complex Adaptive Systems Made up of Networks
  • 19. What Else Works in Networks?
  • 21. The Tipping Point and Social Networks www.flickr.com
  • 24. Medical Center Strategic Portfolio Personalized Health Care Education Signature Programs Research Innovation and Academic excellence Transplantation Neurosciences Critical Care intellectual impact and knowledge Imaging Cancer Heart Key Research Programs Human Genetics Creating the future Biomedical Informatics of medicine to Behavioral Medicine improve people’s Patient Care lives Clinical Excellence and Service Delivery
  • 25.
  • 26. Personalized Health Care is P4/Systems Medicine
  • 27. Wellness from the Individual to the World Resilience To Sustainability
  • 28. P4 Medicine Partnerships 28
  • 29. Predictive Using a person’s genetic makeup and family history to Preventive generate predictions about his or her health Personalized Participatory 29
  • 30. Diane Balster • Genetic testing revealed BRCA2 mutation • Chose preventive procedures to minimize her risk • Predictive care at Ohio State gives people the knowledge they need to make informed decisions 30
  • 31. Predictive Using a person’s health- related information to Preventive prevent disease before it starts Personalized Participatory 31
  • 32. Medical Genetics at Ohio State • Hereditary Heart Rhythm Disorders Clinic • High Risk Family Heart Clinic • Clinical Cancer Genetics Program • Coriell Personalized Medicine Collaborative • Heather Hampel, genetics counselor and ABGC president Heather Hampel, MS, CGC 32
  • 33. Predictive Customizing medical care to the individual patient Preventive Personalized Participatory 33
  • 34. Janet Graves • Routine test revealed hypertrophic cardiomyopathy • Chose to treat condition with implantable cardiac defibrillator • Extended family undergoing genetic testing 34
  • 35. Predictive Encouraging patients to actively participate in their Preventive personal choices about illness and well-being Personalized Participatory 35
  • 36. Rita Brosie • Chose Ohio State for her bariatric surgery • Ohio State is a Bariatric Surgery Center of Excellence • Rita’s participation in her own care plan is key to her continued success 36
  • 37. Your Plan for Health • Faculty and staff YP4H wellness program at Ohio State • Provides tools and programs that help faculty and staff and their families take a proactive approach to their health • Incentivizes healthy behaviors 37
  • 38. OSUMyChart • Provides secure online access to patient information and health services • IHIS: a single, electronic, personalized health record for the entire Medical Center • Improves the quality, safety and efficiency of our care. 38
  • 39. P4 Medicine in Medical Curriculum • Curriculum restructure prepares future doctors to practice P4 Medicine • Greater focus on predictive medicine and preventive health care • Use of mobile devices like iPod touch at the bedside promotes participatory medicine • Clinical Skills Education and Assessment Center Catherine Lucey, MD expansion helps prevent medical complications 39
  • 40. P4 Medicine: Disease to Wellness How Do We Define Wellness?
  • 42. Behavior Environment Gene
  • 43. Defining and Quantifying Health Health is a state of complete physical, mental, and social well-being and not Behavior merely the absence of disease or infirmity. -- WHO, 1948 Environment Health is the ever-changing process of achieving individual potential in the physical, emotional, social, mental, Genetics spiritual, and environmental dimensions. -- Bridget Melton, 2010 Physical
  • 44. Dimensions for Measuring Health • Optimism • Faith/Spiritual • Relationship: family and Behavior social network • Empathy • Social functioning Environment • Lifestyles Genetics Physical
  • 45. Dimensions for Measuring Health Behavior • Diet / Nutrition • Sleep / biorhythm • Micro-biomes Environment • Geo-locations • Employment / workplace • Culture Genetics Physical
  • 46. Dimensions for Measuring Health Behavior Environment • Family health history • Genetic test (SNPs) • Pharmacogenomics test Genetics • DNA sequences and epigenetics • Transcriptomics • Targeted genetic screening • Network analysis (systems and Physical computational biology)
  • 47. Dimensions for Measuring Health Behavior Environment Genetics • Biometrics • Autonomic nervous system • Grip /core strengths • Balance Physical • Endurance • Cognitive functioning • Bio markers
  • 48.
  • 50. Two Main Pilot Projects: Wellness and Care Coordination in Chronic Disease wellness.ucsd.edu/WhatisWellness.shtml kardiol.com/?tag=heart-failure
  • 51. P4 Approach to Wellness Longitudinal Optional special and/or virtual clinics that meet individual needs PHA/Biomarker data leads to Care Team review and Molecular Diagnostics • Biomarker and Genetic risk factor recommendations Genetic Counseling awareness and education • Behavioral risk factor awareness and mitigation strategies; Your Strategic Plan For Behavioral Health happiness, optimism Health • Sleep medicine and circadian Sleep Medicine & rhythm analysis Circadian Rhythm • Assist individuals for best rest to Customer visit medical home promote health team and/or family physician to review and finalize plan: • Evidence-based • Current strengths and Nutrition recommendations weaknesses • Nutrition and diet changes that • Opportunities for meet each person’s unique needs improvement • Health and wellness targets for • Exercise and physical next 2, 5, and 10 years Exercise & performance performance routines designed • Action Plan: recommendations for individual needs
  • 52. Chronic Disease Identify Stratify Prevent/Treat acl.com www.indezine.com/.../peopleanimation_02.jpg www.socialsecurityinsider.com/wp-content/uplo
  • 53. Principles of Transforming Health Care • Reduce variability and deliver evidence-based medicine (Personalize) • Stratify patients to create smaller, precise groups (Predict, Prevent, Personalize) • Analyze data to create knowledge (Predict, Prevent, Personalize) • Activate patients (Participation)
  • 54. Reduce Variability to Decrease Cost and Increase Quality
  • 55.
  • 56.
  • 58. Single Nucleotide Polymorphisms in Clinical Medicine: Pharmacogenomics Pharmacogenomics science.marshall.edu pharmainfo.net
  • 59. Analyze Data to Create Knowledge
  • 61. Hubs are Strong Links in Networks
  • 62. Group Working on Complex Adaptive Systems and Networks in Health Care
  • 63. Identify Networks and Key Regulatory Nodes Controlling Networks http://mcdb.colorado.edu/courses/3280/lectures/class16-2.html
  • 66. The Power of Networks • 500 M users – 50% on line at any one time • 700 B minutes a month • 177 M tweets/day • 572K new accts/day jeichert.wordpress.com
  • 67. You Tube is the 2nd Most Used Search Engine on the Internet
  • 68. 1 in 75 People on the Planet is Playing Farmville www.slideshare.net/avantgame/born-to-play-games-a-talk-by- jane-mcgonigal-about-human-destiny-circa-2020-ad
  • 69. Networks, Participation, the Power of Games and Crowdsourcing
  • 71. Finding the Red Balloon techcrunch.com
  • 72. What Are Health Applications?
  • 73.
  • 75. Social Media and Smoking Cessation http://www.euroclinix.net/health-news/smoking- www.health.com/.../0,,20209135,00.html cessation/facebook-helping-people-to-kick-the-habit-231.html
  • 76.
  • 77. Personalized Medicine Home Dedicated PCP or NP Assigned Telemed tools Care Coordinator Visits, Lab- Patient Test, and tracking Referral and registry tracking functions Patient self- management support
  • 78. Be the Change That You Want to See in the World Mahatma Gandhi