Here, I present the recent updates about n-CoV known as " Corona Virus". History of Corona virus Introduction of corona virus Types of corona virus (CoV) Pathogenesis of nCoV Diagnosis treatment

1. Presented by:-
Mr. Pankaj Kushwaha
Ms. AnURpa Tomar & Ms. Palak Agrawal
Bundelkhand University Jhansi
Corona Virus

2.  Discovered in the 1960s.
 The earliest ones discovered were infectious bronchitis
virus in chickens and two viruses from the nasal cavities of
human patients with the common cold that were
subsequently named human corona virus 229E and human
corona virus OC43.
 Other members of this family are SARS-CoV in
2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-
CoV in 2012, and 2019-nCoV in 2019; most of these have
been involved in serious respiratory tract infections.

3.  "coronavirus" is derived from the Latin corona and the
Greek κορώνη (korṓnē, "garland, wreath"), meaning crown or halo.
 A coronavirus is a kind of common virus that causes an infection in
your nose, sinuses, or upper throat. most corona viruses are not
dangerous.
 Most CoV spread the same way other cold-causing viruses do:
through infected people coughing and sneezing, by touching an
infected person's hands or face, or by touching things such as
doorknobs that infected people have touched.
 Coronaviruses can cause multiple system infections in various
animals and mainly respiratory tract infections in humans, such as
severe acute respiratory syndrome (SARS) and Middle East
respiratory syndrome (MERS).
 At present, information regarding the epidemiology and clinical
features of pneumonia caused by 2019-nCoV is scarce.

4. Corona viruses are named for the crown-like spikes on their
surface. There are four main sub-groupings of corona viruses,
known as alpha, beta, gamma, and delta.
Common human corona viruses
I. 229E (alpha corona virus)
II. NL63 (alpha corona virus)
III. OC43 (beta corona virus)
IV. HKU1 (beta corona virus)
Other human corona viruses
I. MERS-CoV (the beta corona virus that causes
Middle East Respiratory Syndrome, or MERS)
II. SARS-CoV (the beta corona virus that causes
severe acute respiratory syndrome, or SARS)
III. 2019 Novel Coronavirus (2019-nCoV)

5. https://www.cdc.gov/coronavirus/2019-
ncov/index.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcorona
virus%2Fnovel-coronavirus-2019.html
https://www.cdc.gov/sars/index.html
https://www.cdc.gov/coronavirus/mers/index.html

6. In December 2019, a
pneumonia outbreak was
reported in Wuhan, China.
On 31 December 2019, the
outbreak was traced to a
novel strain of corona
virus, which was labeled
as2019nCoV by the World
Health Organization
(WHO).
As of 6 February 2020
(09:41 GMT), there have
been 565 confirmed deaths
and more than 28,339
confirmed cases in the
in 28 countries.

7. 565+

8. https://www.washingtonpost.com/world/2020/01/22/mapping-
spread-new-coronavirus/?arc404=true

9. After the virus enters the host cell and uncoats, the genome is transcribed and then translated. A unique
feature of replication is that all the mRNAs form a “nested set” with common 3′ ends; only the unique
portions of the 5′ ends are translated. There are 7 mRNAs produced. The shortest mRNA codes for the
nucleoprotein, and the others each direct the synthesis of a further segment of the genome. The proteins are
assembled at the cell membrane and genomic RNA is incorporated as the mature particle forms by budding
from internal cell membranes.
MultiplicationofCoronavirus

10. Infected cells become
vacuolated, show
damaged cilia, and may
form syncytia.
Cell damage triggers
the production of
inflammatory mediators,
which increase nasal
secretion and cause local
inflammation and
swelling.
These responses in turn
stimulate sneezing,
obstruct the airway, and
raise the temperature of
the mucosa
Pathogenesis of nCoV

11. There are no FDA-approved diagnostics for
2019-nCoV.
Diagnostic Emergency Use
Authorizations (EUAs):
 FDA requests that diagnostic test sponsors
interested in potential EUA for tests to detect 2019-
nCoV contact CDRH-EUA-Templates@fda.hhs.gov for
further information and templates. Also see: How to
Submit a Pre-EUA for In vitro Diagnostics to FDA
 On February 4, 2020, FDA authorized emergency
use of the CDC 2019-Novel Coronavirus (2019-nCoV)
Real-Time RT-PCR Diagnostic Panel. For additional
technical information and fact sheets,
see: Emergency Use Authorizations (Devices).

13. So far no specific medicine and no vaccine has
been made for corona virus.