19. DRUG RECEPTORS Nuclear receptors Steroid hormones Thyroid hormone 4 Enzyme-linked receptors Insulin Growth factors 3 G-Protein coupled receptors Slow transmission e.g. norephinephrine 2 Ligand gated ion chanels Fast neurotransmittors e.g. acetylcholine 1 STRUCTURE ENDOGENOUS LIGAND SUPERFAMILY
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43. TIME - RESPONSE RELATIONSHIPS Latency Duration of Response Maximal (Peak) Effect Effect/ Response Time
44. TIME - RESPONSE RELATIONSHIPS Effect/ Response Time IV SC IM
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46. POTENCY Effect Dose A B Which drug is more potent? A! Why? Therapeutic Effect
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48. DOSE - RESPONSE RELATIONSHIPS Which drug has the lower threshold dose? Effect Dose A B Which has the greater maximum effect? A B Therapeutic Effect
52. PHASES AFFECTING DRUG ACTIVITY Absorption Distribution Metabolism Excretion I – Pharmaceutical Phase II – Pharmacokinetic Phase III – Pharmacodynamic Phase Administration Drug available for absorption Drug available for action EFFECT Disintegration of dosage form Dissolution of drug Drug-receptor Interaction Dose of formulated drug