Startup: Pharmacelera

1. Enric Gibert - PhD, CEO
Boston, October 18th 2016
President’s Startup Challenge
NEXT GENERATION DRUG DISCOVERY SOLUTIONS

2. Disruptive Solutions Mandatory to Improve R+D
Pharmaceutical R+D
Productivity is Lowering
High R+D costs
Lower patent lifetime
Fewer New Molecular Entities (NME)
RETURN ON
INVESTMENT

3. We Find Better Molecules Faster
Pharmacelera develops software and hardware solutions for drug discovery that...
❶ …find better candidate molecules…
More chances to become a drug
More chances to be patented
+1% SUCCESS RATE +$52M BENEFITS

4. We Find Better Molecules Faster
Pharmacelera develops software and hardware solutions for drug discovery that...
❶ …find better candidate molecules…
More chances to become a drug
More chances to be patented
❷ …in less time!
More time to design better molecules
+1% SUCCESS RATE +$52M BENEFITS

5. PharmDB
Fragment and compound data base
with pre-computed descriptors
We Own Disruptive Technology
USERS
Computational and
medicinal chemists
PharmDesign
SOFTWARE
HARDWARE
PharmEngine
Molecular algorithms based on full 3D
representation of the interaction fields
Based on 15+ years of research at CBDD research group (UB)
PharmScreen
Accurate virtual screening
GRAPHICAL USER INTERFACE
APPLICATIONS
PharmQSAR
3D Quantitative Structure-
Activity Relationship (QSAR) tool
CORE SOFTWARE TECHNOLOGY
PharmaBox
Computing platform equipped
with hardware accelerators
Based on 20+ years of experience on
hardware design and programming
USABILITY
NEW AND BETTER
MOLECULAR SKELETONS
FASTER RESULTS AND USABILITY
CORE HARDWARE
TECHNOLOGY

6. 0
0,2
0,4
0,6
0,8
1
Input 1 Input 2
Traditional platform PharmaBox by Pharmacelera
0,00%
20,00%
40,00%
60,00%
80,00%
100,00%
CDK2 HSP90 TK MCH PDE5
Best software from competition PharmEngine by Pharmacelera
We Own Disruptive TechnologyACCURACY
PharmaBox: THE HARDWARE PLATFORMPharmEngine: THE ALGORITHMS
Electrostatic
fields
Steric
fields
Hydrophobic
Fields
OUR SOFTWARE FINDS 4X MORE ACTIVE COMPOUNDS
THE 2 PILLARS OF OUR TECHNOLOGY
OUR HARDWARE PROVIDES ANSWERS 20 TIMES FASTER TO CUSTOMERS
Xeon Phi
Graphics Processing Units
(GPU)
Field-Programmable Gate Arrays
(FPGA)
TIME
Higher
is
better
Lower
is
better

7. • We use a flexible customer engagement strategy
• Proof-of-concept vs. free demos
• Different pricing strategies based on customer segmentation
Pharmacelera Uses a Scalable Business Model
CLOUD
PharmScreen
PharmQSAR
PharmaBoxHW
SW
CUSTOMERS
Software-as-a-Service
Hardware-as-a-Service
PharmScreen
PharmQSAR
SW
PharmScreen
PharmQSAR
PharmaBoxHW
SW
Hardware/Software
usage license
Pharma R&D departments Contract Research Organizations (CROs)Biotech Academia
€
€
Software
usage license
€

8. High Growth Market with Big Opportunities
$1.5B
2020
SCHRÖDINGER
13% CERTARA
18%
OTHERS
33%
DS BIOVIA
(Accelrys)
38%
$625M
2016
Compound Annual Growth Rate = +25% Hardware
Acceleration
No acceleration
Little
acceleration
Full
acceleration
Pharmacophore One
interaction field
Precision
All
interaction fields

9. Strong Growth Based on Best-in-Class Strategy
2019 20202018201720162015
WORLD-WIDE REFERENCE
LIGAND-BASED CADD
COMPANY
FOUNDATION
Revenue 5,000 € 150,000 € 510,000 € 2M € 4.3 M €
Employees 6 8 11 17 25
+ Presence UK
+ Presence US (West)
+ Presence Germany + Presence Switzerland+ Presence US (East)
TECHNOLOGY
PharmQSAR 1.0
PharmScreen 1.0
PharmQSAR 1.1
PharmScreen 2.0
PharmaBox 1.0
PharmQSAR 1.2
PharmScreen 2.1
PharmDesign 1.0
PharmaBox 1.1
PharmQSAR 1.3
PharmScreen 3.0
PharmDesign 1.1
PharmaBox 2.0
PharmQSAR 1.4
PharmScreen 3.1
PharmDesign 2.0
PharmaBox 2.1
INTERNATIONAL
DEPLOYMENT
Headquarters and R+D
Barcelona

10. We Are a Strong Multi-Disciplinary Team
Enric Gibert - CEO
10 years experience at INTEL
Enric Herrero - CTO
3 years experience at INTEL
Javier Luque – Scientific Director
CBDD research group leader (UB)
Manel López – Commercial Advisor
Head of Computational Chemistry at AB Science (France)
Oscar Farrés – Financial Advisor
Investment manager at European Investment Fund (Luxembourg)
Business Development
Advisor
Marketing &
Communications
Advisor
Albert Zamora – Strategy Advisor
Founder and CEO at Bionure (United States)
Joan Bigorra – Scientific Advisor
Director Strategy/Innovation at Barcelona ISGlobal
EXECUTIVE TEAM
ADVISORY BOARD

11. Why is Pharmacelera here Today?
and
? ?
GROW ADVISORY BOARD
❸❶
MISSION ALIGNMENT
❷
COLLABORATIONS
PRESIDENT’S STARTUP CHALLENGE and
❶
RECOGNITION
❷
MENTORSHIP = ACCELERATE STRATEGY
AND INTERNATIONALIZATION
❸
THOMSON REUTERS = BUSINESS INTELLIGENCE

12. THANK YOU!
info@pharmacelera.com
Partnerships and collaborations: