Aminoglycosides

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Piyalee Rakesh

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INTRODUCTION Aminoglycosides are a class of antibiotics used mainly in the treatment of aerobic gram-negative bacilli infections, although they are also effective against other bacteria including Staphylococci and Mycobacterium tuberculosis. They are often used in combination with other antibiotics. Streptomycin – 1944 Actinomycetes – Streptomyces griseus Bactericidal antibiotics which is interfere with protein synthesis Used to treat aerobic Gram –ve bacteria Exhibit ototoxicity and nephrotoxicity MECHANISM OF ACTION These drugs inhibit protein synthesis in the bacteria, there permeability is increased and cell contents leak out and death of cell occurs. These drugs leave bactericidal action. CLINICAL USES Gram –ve bacillary infection – Septicaemia, pelvic & abdominal sepsis Bacterial endocarditis – enterococcal, streptococcal or staphylococcal infection of heart valves Pneumonias, Tuberculosis Tularemia Plague, Brucellosis Topical – Neomycin, Framycetin:- Infections of conjunctiva or external ear and also used it before surgery. COMMON INDICATIONS OF AMINOGLYCOSIDES Gram negative bacillary infections particularly septicemia, meningitis, UTI’s renal, pelvic and abdominal sepsis. Bacterial endocarditis: usually gentamicin is preferred as a part of regimen. Other infections such as tuberculosis, plague, brucellosis etc. Topical uses: neomycin, framycetin and sisomicin are used for various topical infections. NURSING IMPLICATIONS The renal function should be regularly monitored. Patients should be regularly enquired about any side effects. Patients should be warned for not driving or operating the machinery. Patient should be advised to take plenty of water during the course. Monitor the sign and symptoms of hearing loss.

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