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ANTI-LEPROTIC DRUGS
Yogapriya.v
B.Opt(IIIyr)
INTRODUCTION
• Leprosy is a disease caused by Mycobacterium leprae
• Lesions of skin and peripheral nerves are characteris...
CLASSIFICATION OF DRUGS
SULFONES • dapsone
ANTITUBERCULAR DRUGS • Rifampicin
• ethionamide
PHENAZINES • clofazimine
ANTIBI...
DIAMINO DIPHENYLSULFONE(DDS,DAPSONE)
• Dapsone are chemically related to sulfonamides
• It is bacteriostatic
• It acts by ...
Adverse effect
• Sensitisation of skin leading to exfoliative dermatitis
• Hemolysis in patients with G-6-PD deficiency
• ...
RIFAMPICIN
• It is bactericidal antibiotic which is effective orally
• It has no serious adverse effects
• But it imparts ...
ETHIONAMIDE
• It is a fast acting drug than dapsone
• But it is more expensive and more toxic
• It is orally effective and...
ANTIBIOTICS
• Antibiotics such as ofloxacin,minocycline and clarithromycin are tried in the
treatment of leprosy
• They ar...
LEPRA REACTION
• The acute exacerbation which occurs during the course of leprosy is called
as lepra reaction
• It occurs ...
THANK YOU FOR
LISTENING 
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Antileprotic drugs

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anti-leprotic drugs

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Antileprotic drugs

  1. 1. ANTI-LEPROTIC DRUGS Yogapriya.v B.Opt(IIIyr)
  2. 2. INTRODUCTION • Leprosy is a disease caused by Mycobacterium leprae • Lesions of skin and peripheral nerves are characteristic feature of this disease
  3. 3. CLASSIFICATION OF DRUGS SULFONES • dapsone ANTITUBERCULAR DRUGS • Rifampicin • ethionamide PHENAZINES • clofazimine ANTIBIOTICS • Ofloxacin • Minocycline • clarithromycin
  4. 4. DIAMINO DIPHENYLSULFONE(DDS,DAPSONE) • Dapsone are chemically related to sulfonamides • It is bacteriostatic • It acts by the same mechanism as sulfonamide Absorption,fate and excretion • Dapsone are completely absorbed from gastrointestinal tract • It is widely distributed in body tissues and fluids • A high concentration is present in skin,especially leprosy affected skin • It is metabolized by acetylation and also glucuronide and sulfate conjugation • The metabolic products are eliminated in urine
  5. 5. Adverse effect • Sensitisation of skin leading to exfoliative dermatitis • Hemolysis in patients with G-6-PD deficiency • Blood dyscrasias like agranulocytosis • Hypothyroidism and goiter Preparation and dose Tablets of dapsone are administered at a dose of 100mg daily
  6. 6. RIFAMPICIN • It is bactericidal antibiotic which is effective orally • It has no serious adverse effects • But it imparts an orange red color to urine,saliva and other secretions Dose 600 mg for two consecutive days in a month
  7. 7. ETHIONAMIDE • It is a fast acting drug than dapsone • But it is more expensive and more toxic • It is orally effective and it is administered daily CLOFAZIMINE • It is a phenazine dye with an anti-inflammatory effect • It has a weak bactericidal action • It can br used in dapsone resistant leprosy,tuberculoid leprosy,for relieving pain of lepra reaction • It produces reddish black color on the skin
  8. 8. ANTIBIOTICS • Antibiotics such as ofloxacin,minocycline and clarithromycin are tried in the treatment of leprosy • They are tried in monotherapy or in multidrug therapy • They can be used in cases either allergic or resistant to dapsone
  9. 9. LEPRA REACTION • The acute exacerbation which occurs during the course of leprosy is called as lepra reaction • It occurs due to various factors like infections,malaria or treatment with sulfones • Lepra reactions are treated with clofazimine or chloroquine • Dapsone is not withdrawn but continued in full doses throughout lepra reactions
  10. 10. THANK YOU FOR LISTENING 

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