The report, “Global Constipation Market” analyzes the currently prevailing condition of the market. For more mail: vikas@konceptanalytics.com

1. Global Constipation Market Report
-----------------------------------------
2016
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2. Executive Summary
 Constipation is a common medical condition common among elderly and women, and is interpreted differently by patients and
physicians. Constipation can be chronic, sometimes severe, and has a significant, even deliberating effect on the quality of life of a
patient. Various treatment options are available for the treatment of constipation and patients often adopt different over-the-counter
remedies for the same. There exist three main types of constipation including Chronic Idiopathic Constipation (CIC), Irritable Bowel
Syndrome (IBS-C) and Opioid Induced Constipation (OIC).
 There exist vast opportunities for prescription drugs in the constipation market. However, OTC drugs and laxatives are generally used
for treating constipation, patients and physicians have started recognizing the importance of branded drugs. Future growth of the
constipation market is based on continued growth of prescription therapies to treat constipation, increased research and development of
novel drugs by biopharmaceutical companies, increasing patient and physician awareness of effective prescription alternatives to Over-
the-Counter medications.
 Growth of the constipation market is driven by several factors including rising prescription opioid consumption, growing ageing
population, vast opportunity for drugs with significant potential in the U.S., rising spending on medicines, growing female population and
rising healthcare expenditure. However, the growth of the market can be hindered by certain challenges including rising tide of OTC
drugs for constipation and lower awareness of prescription medication for OIC.
 The report, “Global Constipation Market” analyzes the currently prevailing condition of the market along with its future scope of
development. The specific markets of the U.S. Japan China and Europe are being discussed in the report. The major trends, growth
drivers as well as issues being faced by the industry are being presented in this report. The major players in the industry are being
profiled, along with their key financials and strategies for growth.
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3. Growth of the constipation market in the U.S. is based on continued growth of prescription therapies to treat constipation,
increased research and development of novel drugs by biopharmaceutical companies and increasing patient and physician
awareness…
 Constipation market of the U.S. reached US$... million in the
year 2014, increasing from US$... million in the previous fiscal
year recording growth at a CAGR of …% for the period spanning
2011-2014.
 The overall prescription volume in the U.S. for constipation
reached …. million units in 2014, increasing from …. million
prescriptions in the previous year.
 Nearly … % of the total constipation market is expected to be
captured by generic drugs, followed by …% share from the
branded generics. However, the branded drugs (including
Amitiza & Linzess) represent merely ….% of the total
constipation market in 2015.
The U.S. Constipation Market by Volume (2012-2014)
The U.S. Constipation Market by Value (2011-2014)
The U.S. Constipation Prescription Market by Drug Type (2015E)
2011 2012 2013 2014
US$Million
2012 2013 2014
Million
Generic Branded Generic Brand Others

4. China is expected to have a modest market opportunity in future also, resulting from several factors including lower
Irritable Bowel Syndrome & Chronic Idiopathic Constipation prevalence rate, low diagnosis rate given lower or little disease
awareness and pricing as a limiting factor on the total market opportunity…
 The overall constipation prevalence (including IBS-C & CIC) in
Japan is estimated to have reached nearly … million of which nearly
..% received medical care or diagnosis for the year 2015.
 The market for Amitiza in Japan is expected to reach US$... million
by the year 2021, increasing from US$... million in 2015 recording
peak penetration of …%.
 The overall prevalence of constipation in China is estimated to have
reached nearly … million patients for the year 2015. The diagnosis
rate however, remained relatively low at … million patients for 2015.
Japan’s Amitiza Drug Market Revenue and Penetration (2015E-2021E)
Japan’s Constipation Market by Volume (2015E- 2025E)
China’s Constipation Market by Volume (2015E-2025E)
2015E 2016E 2017E 2018E 2019E 2020E 2021E 2022E 2023E 2024E 2025E
Million
Patient Prevalance Patients with Medical Care (%)
2015E 2016E 2017E 2018E 2019E 2020E 2021E
Percentage
US$Million
Sales Penetration Rate (%)
2015E 2016E 2017E 2018E 2019E 2020E 2021E 2022E 2023E 2024E 2025E
Million
Patient Prevalance Diagnosed Population

5. In Europe, there exists significant unmet needs including lack of familiarity with IBS-C, difficulty in diagnosis and lack of
effective treatments for the multiple symptoms of the disorder...
 Nearly … million people in the U.S. are expected to suffer from
chronic constipation in the year 2016, increasing from … million
patients in the previous fiscal.
 There were about … million IBS-C patients in Europe in the year
2014, and about …million of them were under treatment for the
same for the given period.
 In 2015, nearly … million people had OIC of which … million had
undergone treatments for the same. The patient volume under
treatment is estimated to reach … million by the end of year 2025.
European IBS-C Market by Volume (2014-2025E)
The U.S. Chronic Constipation Market by Volume (2014-2025E)
European Opioid Induced Constipation Market by Volume (2015-2025E)
2014 2015 2016E 2017E 2018E 2019E 2020E 2021E 2022E 2023E 2024E 2025E
Million
Patient Prevalance Patients Under-Treatment
2014 2015 2016E 2017E 2018E 2019E 2020E 2021E 2022E 2023E 2024E 2025E
Million
Patient Prevalence Patients under Treatment
2015 2016E 2017E 2018E 2019E 2020E 2021E 2022E 2023E 2024E 2025E
Million
Patients on Opioid Patients under Treatment

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