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Alcohols www.freelivedoctor.com
ALCOHOLS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Ethyl Alcohol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Alcoholic Beverages www.freelivedoctor.com
Estimates of Blood Alcohol Levels ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Estimates of Blood Alcohol levels  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Metabolic Pathways ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Phases of Liver Ethanol Oxidation www.freelivedoctor.com
Metabolism Of Ethanol www.freelivedoctor.com
MEOS PATHWAY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Summary Of Ethanol Oxidizing Enzyme Systems   www.freelivedoctor.com
CNS EFFECTS OF ETHANOL ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Ligand-gated ion channels: allosteric enhancement  Ion channel pore GABA barbiturates Cl - Cl - Ethanol ? Intracellular Extracellular benzodiazepines www.freelivedoctor.com
Signs & Symptoms www.freelivedoctor.com
Cardiovascular Effects of Ethanol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Gastrointestinal Effects of Ethanol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Cell & Organ damage by Ethanol www.freelivedoctor.com
Streissguth, 1994   Facies in Fetal Alcohol Syndrome www.freelivedoctor.com
Fetal Alcohol Syndrome ,[object Object],[object Object],[object Object],Photo courtesy of Teresa Kellerman  www.freelivedoctor.com
Ethanol Drug Interactions www.freelivedoctor.com
Acute Ethanol Intoxication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Tolerance & Physical Dependence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Alcoholism & Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Methanol Industrial Solvent, Gasoline additive, home heating Oxidized by the ADH enzyme system Death from 2-8 oz methanol ingestion Ethanol or 4-MP dosage may rescue poisoning www.freelivedoctor.com
Ethylene Glycol Heat exchanger in antifreeze formulations Industrial solvent more poisonous to humans than to animals Metabolized by the ADH enzyme system Acute renal failure from oxalate crystal deposition Treatment with ethanol or 4-MP may treat acute poisoning www.freelivedoctor.com
Drugs for Treatment of Alcohol Abuse & Alcoholism www.freelivedoctor.com

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