The document discusses biodegradable ceramic-polymer composites for biomedical applications. It introduces biopolymers and biodegradable materials. Common issues with permanent implants like stress shielding and inflammation are described. The need for biodegradable implants that can degrade over time without issues is explained. Different types of biodegradable ceramic-polymer composites are summarized, including those based on silica, bioglass, wollastonite and calcium phosphates. These composites can provide controlled properties for tissue engineering by combining ceramics and polymers. In conclusion, biodegradable ceramic-polymer composites offer advantages over isolated ceramics or polymers for regenerative medicine applications.

1. RANJU M R
16ML14F
BIODEGRADABLE CERAMIC-POLYMER
COMPOSITES FOR BIOMEDICALAPPLICATION
RANJU M R
16ML14F
Materials engg
NIT karnataka.

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 INTRODUCTION
 APPLICATION
 NEED
 EXAMPLES
 SUMMARY
CONTENTS

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BIOMATERIALS
• Non-living materials mainly used for medical purposes.
• Designed to interact with biological systems.
BIODEGRADABLE MATERIAL
• Its mechanical properties does not change during its life time.
• It gets degrades gradually without leaving trace.
TISSUE ENGINEERING
Maintenance, replacement or regeneration of damaged biological tissues.
INTRODUCTION

4. APPLICATIONS
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BIOMEDICAL
FIELD
scaffolds

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 Repeat surgery necessary.
 Inability to adapt to growth.
 Stress shielding, corrosion, accumulation of metal in tissues.
 Thrombogenicity and long term endothelial dysfunction.
 Chronic inflammatory local reactions.
 Physical irritations.
PERMANENT IMPLANTATION- PROBLEMS
HOW TO OVER COME?

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BIODEGRADABLE
POLYMERS
SYNTHETIC POLYMER
PLA
PGA
PCL
 Synthetic polymer Good mechanical strength
 To improve biodegradability,biocompatibility & biofunctinality.
“ BIODEGRADABLE CERAMIC- POLYMER COMPOSITE ” is used
SOLUTION
NATURAL POLYMER
PROTEINS
POLYSACCHARIDES

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BIODEGRADABLE CERAMIC-POLYMER
COMPOSITE
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 Ceramic-polymer composite :
Ceramic fillers incorporated to polymer matrices .
 Commonly used ceramic polymer composites are ;
1. Silica based composite.
2. Bio glass based composite.
3. Wollastonite based composite.
4. Calcium phosphate ceramics based composite.
Michal Dziadek, Ewa Stodolak ” Biodegradable ceramic-polymer composites for biomedical applications: a review. C71 (2016)

8. SILICA BASED COMPOSITE
 Higher biocompatibility.
 Higher bioresorption rate and porosity.
 Improves stability, adhesion and mechanical properties.
PLA/SiO2 membrane after 8 week incubation in H2O/37°C/PBS

9. BIOGLASS BASED COMPOSITE
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1. SILICATE BIOACTIVE GLASS
• SiO2–Na2O–CaO–P2O5 system – Bioglass® 45S5.
• Ionic dissolution product stimulate osteoblastic and stem cell growth.
2. BORATE & BOROSILICATE BIOACTIVE GLASSES
• High reactivity and bioactivity.
• Lower biocompatibility due to cytotoxicity by borate ions.
3. PHOSPHATE GLASSES
• P2O5-CaO-Na2O system.
• Chemical similarity to the inorganic phase of human bone.
• Dissolution product of PBG enhance proliferation of osteoblastic cells.
Michal Dziadek, Ewa Stodolak ” Biodegradable ceramic-polymer composites for biomedical applications: a review. C71 (2016)

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TISSUE REGENERATION

11. CONCLUSION
 Composite material provides greater possibility to control their material
and biological properties than the ceramics and the polymer alone.
 Mean features for the medical applications can be controlled by using
different types of ceramics.
 It provides a number of unique and beneficial properties for tissue
engineering and regenerative medicine.

12. REFERENCES
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1. Michal Dziadek, Ewa Stodolak ” Biodegradable ceramic-polymer
composites for biomedical applications: a review.
2. R. Gref, Y.Minamitake,M.T. Peracchia, V. Trubetskoy, V. Torchilin,
Langer, Biodegradable long-circulating polymeric nanospheres.
3. L.S. Nair, C.T. Laurencin, Biodegradable polymers as biomaterials,
progress in polymer ,Science (Oxford) 32 (8–9) (2007) 762–798
4. https://www.omicsonline.org

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