Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

biodegradable ceramics polymer matrix composite for bio medical application

978 views

Published on

This presentation content is an important field of research now a days.

Published in: Technology
  • Login to see the comments

biodegradable ceramics polymer matrix composite for bio medical application

  1. 1. RANJU M R 16ML14F BIODEGRADABLE CERAMIC-POLYMER COMPOSITES FOR BIOMEDICALAPPLICATION RANJU M R 16ML14F Materials engg NIT karnataka.
  2. 2. 2  INTRODUCTION  APPLICATION  NEED  EXAMPLES  SUMMARY CONTENTS
  3. 3. 3 BIOMATERIALS • Non-living materials mainly used for medical purposes. • Designed to interact with biological systems. BIODEGRADABLE MATERIAL • Its mechanical properties does not change during its life time. • It gets degrades gradually without leaving trace. TISSUE ENGINEERING Maintenance, replacement or regeneration of damaged biological tissues. INTRODUCTION
  4. 4. APPLICATIONS 4 BIOMEDICAL FIELD scaffolds
  5. 5. 5  Repeat surgery necessary.  Inability to adapt to growth.  Stress shielding, corrosion, accumulation of metal in tissues.  Thrombogenicity and long term endothelial dysfunction.  Chronic inflammatory local reactions.  Physical irritations. PERMANENT IMPLANTATION- PROBLEMS HOW TO OVER COME?
  6. 6. 6 6 BIODEGRADABLE POLYMERS SYNTHETIC POLYMER PLA PGA PCL  Synthetic polymer Good mechanical strength  To improve biodegradability,biocompatibility & biofunctinality. “ BIODEGRADABLE CERAMIC- POLYMER COMPOSITE ” is used SOLUTION NATURAL POLYMER PROTEINS POLYSACCHARIDES
  7. 7. 7 BIODEGRADABLE CERAMIC-POLYMER COMPOSITE 7  Ceramic-polymer composite : Ceramic fillers incorporated to polymer matrices .  Commonly used ceramic polymer composites are ; 1. Silica based composite. 2. Bio glass based composite. 3. Wollastonite based composite. 4. Calcium phosphate ceramics based composite. Michal Dziadek, Ewa Stodolak ” Biodegradable ceramic-polymer composites for biomedical applications: a review. C71 (2016)
  8. 8. SILICA BASED COMPOSITE  Higher biocompatibility.  Higher bioresorption rate and porosity.  Improves stability, adhesion and mechanical properties. PLA/SiO2 membrane after 8 week incubation in H2O/37°C/PBS
  9. 9. BIOGLASS BASED COMPOSITE 9 1. SILICATE BIOACTIVE GLASS • SiO2–Na2O–CaO–P2O5 system – Bioglass® 45S5. • Ionic dissolution product stimulate osteoblastic and stem cell growth. 2. BORATE & BOROSILICATE BIOACTIVE GLASSES • High reactivity and bioactivity. • Lower biocompatibility due to cytotoxicity by borate ions. 3. PHOSPHATE GLASSES • P2O5-CaO-Na2O system. • Chemical similarity to the inorganic phase of human bone. • Dissolution product of PBG enhance proliferation of osteoblastic cells. Michal Dziadek, Ewa Stodolak ” Biodegradable ceramic-polymer composites for biomedical applications: a review. C71 (2016)
  10. 10. 10 TISSUE REGENERATION
  11. 11. CONCLUSION  Composite material provides greater possibility to control their material and biological properties than the ceramics and the polymer alone.  Mean features for the medical applications can be controlled by using different types of ceramics.  It provides a number of unique and beneficial properties for tissue engineering and regenerative medicine.
  12. 12. REFERENCES 12 1. Michal Dziadek, Ewa Stodolak ” Biodegradable ceramic-polymer composites for biomedical applications: a review. 2. R. Gref, Y.Minamitake,M.T. Peracchia, V. Trubetskoy, V. Torchilin, Langer, Biodegradable long-circulating polymeric nanospheres. 3. L.S. Nair, C.T. Laurencin, Biodegradable polymers as biomaterials, progress in polymer ,Science (Oxford) 32 (8–9) (2007) 762–798 4. https://www.omicsonline.org
  13. 13. 13 THANK YOU

×