Neonatal necrotizing enterocolitis
NEC is the most common life-threatening emergency of the gastrointestinal tract in the newborn period. The disease is characterized by various degrees of mucosal or transmural necrosis of the intestine. The cause of NEC remains unclear but is most likely multifactorial. The incidence of NEC is 1-5% of infants in neonatal intensive care units (NICUs). Both incidence and case fatality rates increase with decreasing birthweight and gestational age. Because very small, ill preterm infants are particularly susceptible to NEC, a rising incidence may reflect improved survival of this high-risk group of patients.
Clinical Manifestations
Infants with NEC have a variety of signs and symptoms and may have an insidious or sudden catastrophic onset (Table 96-1). The onset of NEC is usually in the 2nd or 3rd week of life but can be as late as 3 mo in VLBW infants. Age of onset is inversely related to gestational age. The 1st signs of impending disease may be nonspecific, including lethargy and temperature instability, or related to gastrointestinal pathology, such as abdominal distention and gastric retention. Obvious bloody stools are seen in 25% of patients. Because of nonspecific signs, sepsis may be suspected before NEC. The spectrum of illness is broad, ranging from mild disease with only guaiac-positive stools to severe illness with bowel perforation, peritonitis, systemic inflammatory response syndrome, shock, and death. Progression may be rapid, but it is unusual for the disease to progress from mild to severe after 72 hr.
Diagnosis
A very high index of suspicion in treating preterm at-risk infants is crucial. Plain abdominal radiographs are essential to make a diagnosis of NEC. The finding of pneumatosis intestinalis (air in the bowel wall) confirms the clinical suspicion of NEC and is diagnostic; 50-75% of patients have pneumatosis when treatment is started (Fig. 96-4). Portal venous gas is a sign of severe disease, and pneumoperitoneum indicates a perforation (Figs. 96-4 and 96-5). Hepatic ultrasonography may detect portal venous gas despite normal abdominal roentgenograms .
2. ā¦Introduction:
ā¦ NEC is the most common life-threatening emergency of the
gastrointestinal tract in the newborn.
ā¦ Various degrees of mucosal or transmural necrosis of the intestine
occurs.
ā¦ The incidence of NEC is 1ā10% of infants in NICU.
ā¦ Although rare, the disease does occur in term infants (10%)
ā¦ The mortality rates vary from 10% to 50% .
Birth weight
Incidence, Fatality
Gestational age
(less than 28 weeks of gestation)
3. ā¦Necrotizing Enterocolitis In The Beginning
ā¦ NEC was unknown as a disease before the 1950ās
ā¦ First described in 1950ās by Schmid and Quaiser
ā¦ ā Case reports describing neonates who died from necrotizing lesions
of their GI tracts.
NEC became recognized as a clinical entity in 1960ās and 1970ās
ā¦ ā At this time NECās mortality exceeded 70%
ā¦ ā NEC was initially described as idiopathic gastrointestinal perforations
5. Def. of NEC
Is an acquired neonatal disorder representing an
end expression of serious intestinal injury after a
combination of vascular, mucosal, and metabolic
(and other unidentified) insults to a relatively
immature gut.
6. Risk factors
ā¦ Prematurity. The lower the gestational age the greater the risk of the NEC, because of the
immaturity of the circulatory, gastrointestinal, and immune systems.
ā¦ Asphyxia and acute cardiopulmonary collapse, as they lead to low cardiac output and
diminished intestinal perfusion.
ā¦ Enteral feeding: NEC is rare in unfed infants. About 90-95% of infants with NEC received at least
one enteral feeding.
ā¦ Enteral feeding provides a substrate for proliferation of enteric pathogens.
ā¦ Hyperosmolar formula may cause direct damage to intestinal mucosa.
ā¦ Lack of the immuno-protective factors in commercially prepared formula.
ā¦ Breast-feeding significantly lowers the risk of NEC ( suggesting that breast milk factors, including growth
factors, antibodies, and cellular immune factors, might be protective).
ā¦ Polycythymia and hyperviscosity syndrome.
ā¦ Exchange transfusion.
ā¦ Large feeding volumes and rapid advancement of enteral feedings.
ā¦ Enteric pathogenic organisms comprising bacterial and viral pathogens. These include E.coli,
Klebsiella, salmonella, rotaviruses, and enteroviruses.
8. Answer :
ā¦By using Umbilical Catheter for
Exchange transfusion , increase in
portal venous pressure that can result
in decrease in ilial and colonic blood
flow
9. ETIOLOGY:
ā¦ Etiology of NEC is unclear; May be multifactorial.
ā¦ Prematurity is the single greatest risk factor.
ā¦ Infants exposed to cocaine have a 2.5 times increased risk
of developing NEC.
The mean gestational age of infants with NEC is 30 to 32
weeks, and the infants generally are weight appropriate
for gestational age.
13. PATHOLOGY AND PATHOGENESIS: contd..
ā¦ NEC probably results from an interaction between loss of mucosal integrity due to factors like
ischemia, infection, inflammation,
and the host's response to that injury like circulatory, immunologic, inflammatory responses
resulting in necrosis of the affected area.
ā¦ Various bacterial and viral agents, including Escherichia coli, Klebsiella, Clostridium perfringens,
Staphylococcus epidermidis, and rotavirus, have been recovered from cultures.
ā¦ However, in most situations, no pathogen is identified.
ā¦ NEC rarely occurs before the initiation of enteral feeding and is much less common in infants
fed human milk.
ā¦ Aggressive enteral feeding may predispose to the development of NEC.
ā¦ Coagulation necrosis is the characteristic histologic finding of intestinal specimens.
14. Question :
ā¦Why drugs like theophylline , sodium
bicarbonate and calcium supplements ,
increase the risk of NEC ?
15. Answer :
ā¦All the previouse medications increase
the osmolarityof the stomach and
intestine .
16. Why the Preterm Gut is Different
ā¦Decreased IgA
ā¦Decreased Intestinal T lymphocytes
ā¦Poor Antibody Response
ā¦Higher Membrane Permeability of GI Epithelial
Lining
ā¦Lower Gastric Motility
ā¦More Scant and More Permeable Mucin Blanket
17.
18. Intestinal Archetecture
Keep in mind we will be
looking at a small slice of an
enormous organ that has
multiple layers of complexityā¦
44. CLINICAL MANIFESTATIONS:
ā¦ Onset can be insidious or rapid.
ā¦ Onset time: The onset of NEC varies; in very low birth weight (VLBW)
infants, NEC is usually diagnosed between 14-20 days of life. In full-term
infants, the age of onset is usually during the first week of life.
ā¦ The postnatal age at onset is inversely related to birth weight and
gestational age.
ā¦ It is unusual for the disease to progress from mild to severe after 72 hr.
45. CLINICAL MANIFESTATIONS:
ā¦ The 1st signs of impending disease may be
-Nonspecific including lethargy and temperature instability
or
-Related to gastrointestinal pathology such as abdominal
distention and gastric retention.
ā¦ Obvious bloody stools are seen in 25% of patients.
ā¦ The spectrum of illness is broad and ranges from
-Mild disease with only guaiac-positive stools to
-Severe illness with bowel perforation, peritonitis, systemic
inflammatory response syndrome, shock, and death.
46.
47.
48.
49. What do we use to determine severity
and medical management in NEC?
60. Diagnosis of NEC
ā¦ Very high index of suspicion.
ā¦ 1. Plain abdominal x-rays :
ā¦ Pneumatosis intestinalis (air in the bowel wall) is diagnostic;
ā¦ Portal venous gas is a sign of severe disease, and
ā¦ Pneumoperitoneum indicates a perforation.
ā¦ 2. Hepatic ultrasonography:
ā¦ May detect portal venous gas despite normal abdominal Xray.
ā¦ 3. Analysis of stool for blood and carbohydrate
ā¦ Carbohydrate malabsorption - positive stool Clinitest result, can be a frequent and
early indicator of NEC.
66. ā¦ Intestinal perforation.
ā¦ Abdominal Xray in NEC demonstrates marked distention and massive
pneumoperitoneum
Free air below the anterior abdominal wall.
67. ā¦ Differential diagnosis of NEC :
ā¦ Specific infections (systemic or intestinal)- Pneumonia,
Sepsis.
ā¦ Gastrointestinal obstruction, volvulus, malrotation,
ā¦ Isolated intestinal perforation.
ā¦ Severe Inherited Metabolic disorders. (e.g., galactosemia
with Escherichia coli sepsis)
ā¦ Feeding intolerance
ā¦ Severe allergic colitis
ā¦ Idiopathic focal intestinal perforation can occur
spontaneously or after the early use of postnatal steroids
and indomethacin.
68. ā¦ TREATMENT:
ā¦ Rapid initiation of therapy is required for suspected as
well as proven NEC cases.
ā¦ There is no definitive treatment for established NEC
and, therapy is directed at supportive care and
preventing further injury with
-Cessation of feeding,
-Nasogastric decompression, and
-Administration of intravenous fluids.
ā¦ Once blood has been drawn for culture, systemic
antibiotics (with broad coverage for gram-positive,
gram-negative, and anaerobic organisms) should be
started immediately.
69. ā¦ TREATMENT: Contd..
ā¦ Umbilical catheters if present should be removed.
ā¦ Ventilation should be assisted as required.
ā¦ Intravascular volume replacement with crystalloid or blood
products.
ā¦ Cardiovascular support with volume and/or inotropes.
ā¦ Correction of hematologic, metabolic, and electrolyte
abnormalities.
ā¦ Careful attention to respiratory status, coagulation profile, and
acid-base and electrolyte balance are important.
70. ā¦MONITORING:
ā¦ Sequential anteroposterior and cross-table lateral or lateral
decubitus abdominal x-rays to detect intestinal perforation;
ā¦ Serial determination of hematologic status,
ā¦ Serial determination of electrolyte status, and
ā¦ Serial determination of acid-base status.
71. ā¦ Indications for surgery :
ā¦ Absolute indications:
ā¦ Evidence of perforation on abdominal roentgenograms
(pneumoperitoneum) or
ā¦ Positive abdominal paracentesis (stool or organism on Gram stain
from peritoneal fluid).
ā¦ Relative indications:
ā¦ Failure of medical management,
ā¦ Single fixed bowel loop on roentgenograms,
ā¦ Abdominal wall erythema, or
ā¦ A palpable mass.
72. ā¦ Ideally, surgery should be performed after intestinal necrosis
develops, but before perforation and peritonitis occurs.
ā¦ Peritoneal drainage may be helpful for patients with peritonitis
who are too unstable to undergo surgery. Peritoneal drainage is
more successful in patients with isolated intestinal perforation.
73. PROGNOSIS.:
ā¦ Medical management fails in about 20ā40% of patients with
pneumatosis intestinalis at diagnosis; of these, 10ā30% die.
ā¦ Early postoperative complications : Wound infection,
dehiscence, and stomal problems (prolapse, necrosis).
ā¦ Later complications : Intestinal strictures develop at the site of the
necrotizing lesion in about 10% of surgically or medically
managed patients.
74. ā¦ PROGNOSISā¦.
ā¦ After massive intestinal resection,
-Complications from postoperative NEC include short-bowel
syndrome (malabsorption, growth failure, malnutrition),
ā¦ Premature infants with NEC who require surgical intervention or who
have concomitant bacteremia are at increased risk for adverse
growth and neurodevelopmental outcome.
ā¦ The overall mortality is 9% to 28% regardless of surgical or medical
intervention.
75. ā¦ PREVENTION:
ā¦ Always better than cure!
ā¦ Newborns exclusively breast-fed have a reduced risk of NEC.
ā¦ Early initiation of aggressive feeding may increase the risk of NEC in VLBW
infants.
ā¦ Gut stimulation protocol of minimal enteral feeds followed by judicious
volume advancement may decrease the risk.
ā¦ Probiotic preparations have also decreased the incidence of NEC. .
Induction of GI maturation.
ā¦ Incidence of NEC is significantly reduced after prenatal steroid therapy.
ā¦ Alteration of the immunologic status of the intestine using immunoglobulin
A (IgA) and immunoglobulin G (IgG) supplementation.
Editor's Notes
NEC is predominantly a disorder of preterm infants, with an incidence of 6-10% in infants
weighing <1.5 kg. The incidence increases with decreasing gestational age. Seventy to 90% of cases
occur in high-risk low birth weight infants, whereas 10-25% occur in full-term newborns. Infants
with NEC represent 2-5% of neonatal intensive care unit (NICU) admissions.(clinical manual )
It has been estimated that 90% of cases occur in premature infants and that NEC may develop in 1% to 10% of infants hospitalized in neonatal intensive care units (84). Significant intercenter differences in the prevalence of NEC have been reported (79). The mortality rates vary from 10% to 50%. The age of onset of NEC is related to birth weight and gestational age. Smaller, more immature infants (less than 28 weeks of gestation) tend to have NEC at an older age than larger, more mature (greater than 31 weeks of age) infants .( avery )
Spontaneous intestinal perforation is a clinical syndrome of undetermined cause resembling
NEC with less systemic involvement and a less severe clinical course. It may represent a variant of
classic NEC.