A 46 year old women presented with
severe headache, palpitation and
O/E - BP-150/90 mm Hg ,
Heart rate- 88/min
Abdominal palpation elicited a rise in BP of
210/120 mm Hg, HR of 122 /min with
severe headache and profuse sweating.
Decreased tone of smooth muscle in
bladder trigone, sphincter and prostate
Increased Intestinal motility
Contraction of vas deferens and related
Highly plasma protein bound
Metabolized in liver and excreted in
With α1 Blocker Without α1 Blocker
Chemically and pharmacologically
similar to prazosin
More water soluble, higher oral
bioavailability and longer plasma t ½
Duration of action extends beyond
18 hours, once daily dosing
Use – More popular than prazosin in
Congener of prazosin with similar
t ½ - 20 hours
Duration of action - 36hrs.
Use - BPH and hypertension.
Uroselective (α1A) alpha blocker.
No CVS side effects like
BP/HR changes at low doses
Use – BPH (dose of 0.4mg/day)
ADR – dizziness and impaired
Important in management of
Postural hypotension, reflex tachycardia
Nasal stuffiness, sexual dysfunction