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OSTEOPOROSIS
OVERVIEW
Osteoporosis Metabolic bone disorder The result is decreased bone mass  Bones become porous, brittle, and abnormally vulnerable to fracture
[object Object]
Secondary to an underlying disease,[object Object]
Classification of Primary Osteoporosis Idiopathic osteoporosis  ,[object Object],Type I (or postmenopausal) osteoporosis  ,[object Object]
Related to the loss of estrogen's protective effect on bone
Results in trabecular bone loss and some cortical bone loss
Vertebral and wrist fractures are common. ,[object Object]
Trabecular and cortical bone loss
fractures of the proximal humerus, proximal tibia, femoral neck, and pelvis,[object Object]
Pathophysiology and etiology
The rate of bone resorption increases over the rate of bone formation ,[object Object],Calcium and phosphate salts are lost ,[object Object],Occurs most commonly in postmenopausal women
COmplications
Fractures ,[object Object],Progressive kyphosis ,[object Object],Chronic back pain from compression fracture
Typical loss of height associated with  osteoporosis and aging
Clinical manifestations
Asymptomatic until later stages Fracture after minor trauma may be first indication Most frequent fractures associated with osteoporosis include fractures of: distal radius vertebral bodies proximal humerus Pelvis proximal femur (hip)
May have vague complaints related to aging process ,[object Object]
Pain
WeaknessEstrogen deficiency may be noted
Diagnostic evaluation
Differential diagnosis ,[object Object]
metastatic carcinoma, advanced multiple myelomaX-rays  ,[object Object],DEXA ,[object Object]
Shows decreased bone mineral density
T score -2.5 or worse,[object Object]
Serum and urine calcium levels ,[object Object],Serum bone GLA-protein ,[object Object]
ElevatedBone biopsy  ,[object Object],[object Object]
Quantitative computed tomography can evaluate bone density
Less available and more expensive than DEXA,[object Object]
GOAL: ,[object Object]
prevent additional fractures
control pain
Treatment:
physical therapy program of gentle exercise and activity
drug therapy to slow disease progress
supportive devices
surgery,[object Object]
Biphosphonates ,[object Object]
To prevent bone loss and reduce the risk of fracturesCalcium and vitamin D supplements  ,[object Object]
Raloxifene and calcitonin
To reduce bone resorption
To slow the decline in bone mass,[object Object]
Supportive devices and surgery
Back brace ,[object Object],Surgery  ,[object Object]
to correct pathologic fractures of the femur
Reduction and Immobilization
with a cast
Required in Colles' fracture
4 to 10 weeks,[object Object]
Diet ,[object Object]
Decreased alcohol consumption and caffeine useRegular Exercise Smoking cessation
Hormonal and fluoride treatment

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Osteoporosis