These slides are from a Health 2.0 New Orleans meeting on November 21, 2013 with special guest speaker Tom Krohn of Eli Lilly.

1. Transforming Drug Development
It’s not just for researchers – you can participate!
Health 2.0 New Orleans
November 21, 2013
Thomas Krohn, RPh, MBA
Eli Lilly and Company

2. Drug Development - today
Precompetitive Competitivepatent
Innovation Process

3. Business Model Performance
Source: FDA.gov
Productivity Down, Costs Up Future revenues under pressure
Unsustainable Business Model

4. Moore’s vs. Eroom’s Law

5. The Far Side
by Gary Larson

6. Incremental Improvement

8. Disruptive Innovation
to S1'
to S2
S1
Time
Performance
Disruptive
Change
Simpler, Faster, Cheaper?

9. Disruption in motion

10. Generation and Access to Data

11. Patient Digital Monitoring

12. Patient Communities
Patients as microexperts – not subjects

13. Patient-Driven Research

14. The Disruption
Power to the Patient

15. Clinical Research as part of Healthcare
Public Perception
• 94% of people recognize the importance of participating in clinical research
in order to assist in the advancement of medical science. Yet 75% of the
general public state they have little to no knowledge about the clinical
research enterprise and the participation process. (www.centerwatch.com)
• Less than five percent of cancer patients participate in clinical trials. If ten
percent participated, studies could be completed in one year, instead of the
three-five years that studies currently require. (National Cancer Institute)
• It's not uncommon for your cancer doctor or treatment team to discuss the
option of a clinical trial as the best treatment choice for your cancer type.
(www.mayoclinic.com)
Standard of Care Clinical Trial
Info & Innovation

16. ClinicalTrials.Gov and Patients
98,000,000
Pageviews/Month1
Sources:
1) clinicaltrials.gov site
2) D. Zarin 2007 Overview
47,000,000
Patient driven pageviews/Month
2
What if….?

17. 1
Patient-
Centric
Design
Patient
Voice
2
Patient-Centric Study Representation & Voice
Study Representation
Informed Consent
DocumentCt.Gov
Study Design
Open
Platform
Patients
• Clear eligibility
• Risk/Benefit
• My doctor’s role
• Study treatment
• Time to results
• Logistics
Design Challenge
ctdesign.challengepost.com
November 14

18. Patient-Centric Information
Open
Platform
Patients
labs.lillycoi.com

19. Clinical Open Innovation
Open
Platform
Patients
api.lillycoi.com
Daily
Updates
Open
Web
REST
API

20. Enabling patient matching to studies
Open
Platform
Patients
api.lillycoi.com
Daily
Updates
Open
Web
REST
API
Patient Study
“Target Profiles”
Study Sponsors
Patient &
Communities
Personal Electronic
Medical Records
Match
Process
Consent
to
Match

21. Patient Engagement App Challenge
http://patientengagement.challengepost.com

22. Join the transformation
• Learn the business model
• Understand patient needs
• Identify options for value creation
• Explore open data and patient engagement
• Participate in challenges
Most people are afraid of making mistakes.
Leaders are afraid of missing opportunities.

23. References
• Website: www.lillycoi.com
• API: api.lillycoi.com
• App Lab: labs.lillycoi.com
• Whitepaper: link
• Twitter: @Lilly_COI, @takmad

24. Thanks!