10. HOW TO GROW
• Cultivation
• Grow in moist but well-drained, deep, humus-
rich, fertile soil. Intolerant of water logging
• Propagation
• Propagate by seed, sowing in containers in an
open frame.
OR
• Separate corms when dormant in summer
11. Constituents
Contains
• colchicine
• capsaicinoids (0.1-1.9%) and the
main among them is capsaicin,
• Nordihydrocapsaicin
• Homodihydrocapsaicin.
• Fruits are rich in vitamins C, B1,
B2, nikotinic and folic acids,
carotinoids;
• Also contains steroidal saponins,
flavonoids, coumarin scopoletin;
• Salts of potassium, sodium,
calcium, aluminium, iron.
12. Concentrations of A.Constituents in
different parts
• Seed :-
• concentrations of colchicine may exceed 1% in
the seeds.
Corms:-
• 0.6% colchicine in corm
Dried leaves:-
• dried flowers and seeds contain 15 times as
much colchicine as fresh leave
15. Anticancer agent
Because colchicine arrests mitosis
during metaphase, it was thought to be
useful as an anticancer agent.
Immunochemotherapy of multidrug
resistant renal cell carcinoma using a
combination of vinblastine, tamoxifen,
colchicine, and 5-flourouracil
demonstrated an overall response rate of
23.5% with limited toxicity
16.
17. pharmacology
• Colchicine inhibits normal cell division,
specifically by interfering with microtubule
growth and mitosis during cell division. It
also may interfere with the normal function
of cyclic adenosine monophosphate
(cAMP) or the cellular membrane
18. Idiopathic pulmonary fibrosis
• A controlled, randomized, prospective trial of
26 patients treated with colchicine or
prednisone showed no improvement with
either agent.
• 20 A prospective, nonrandomized study using
colchicine and/or D-penicillamine with
prednisone did not halt progression of
idiopathic pulmonary fibrosis.
• 21 One retrospective study comparing
colchicine, oxygen, and prednisone with no
therapy demonstrated no differences in
survival
19. Dosing
• Colchicine 1 to 2 mg is a typical oral dose
for gout,
• Colchicine also has been studied for
osteoarthritis of the knee, refractory
constipation, at similar doses.
• Its narrow therapeutic index requires
medical supervision.
20.
21. According to BBC News
• Researchers are poised to start clinical trials
with a new "smart bomb" treatment, derived
from the flower, targeted specifically at
tumours.
• The treatment, called colchicine, was able to
slow the growth of and even completely "kill"
a range of different cancers, in experiments
with mice.
• The research was highlighted at the British
Science Festival in Bradford.
22. According to Department of Life Science,
College of Natural Science, Daejin
University, Kyeonggido, Korea.
• The colchicine derivative CT20126 shows
a novel microtubule-modulating activity
with apoptosis