This PPT says about the medicinal uses of snake venom. I gave detailed information about it.

1. MITS COLLEGE OF PHARMACY
MEDICINAL USES OF SNAKE
VENOM
Presented by
Sai Krishnaja Sravanthi Paruchuri
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2. 1. Definition of venom
2. Venom extraction process
3. Composition of snake venom
4. Types of Venom
5. Therapeutic Uses of Neurotoxins
6. Therapeutic Uses of Hemotoxins
7. Therapeutic Uses of Cytotoxins
8. Adverse Effects
9. Conclusion
10. References
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3. What is Venom?
 Venom is nothing but a
secretion of venomous animals,
which are synthesized in a
specific part of their body, called
Venom gland.
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4. How to extract snake venom?
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Venom extraction process
 Hold the snake around its neck using four fingers, with the thumb
infront.
 Place pressure on the hand while moving it upward and
downward. This will make the snake aggressive. He will open his
mouth, expose his fangs and start spitting.

5.  That venom is collected in a container and is quickly freeze-
dried to preserve its biological properties.
 The process of extracting venom is called “Milking”.
Venom Freeze-dried venom
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6. Composition Of Snake Venom
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Enzymes
Phospholipase A2
Phosphodiesterase
Phosphomonoesterases
L-amino acid oxidase
Proteins
Disintegrin
Ancrod
Organic
compounds
Citrate
Nucleosides
Acetyl choline
Peptides
Bradykinin –Potentiating
Peptides (BPP)

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Venom
Neurotoxins Eg. Cobra
Hemotoxins Eg. Russel’s
viper
Cytotoxins Eg. Rattle
snakes
Types of Venom

8. Therapeutic Uses of
Neurotoxins
• China uses cobra venom to treat opium addiction, liver, lung,
esophageal and skin cancers as well as leukemia and arthritis.
• India uses Cobra venom as a hepatic stimulant and to revive
collapsed patients.
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• Neurotoxins target the central nervous system. They stop
muscles from working.

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Cobra venom; A powerful painkiller that
works as well as morphine but without the side
effects.

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• Cobra venom is safe and non-addictive way to treat
pain , When compared to opiates.

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• cobra venom has the potential to slow down the degeneration of
joints as in Rheumatoid Arthritis. It also reportedly has anti-
depressive activity.
• At Recepto pharm researchers are also currently doing research
on Herpes, HIV/AIDS and Multiple Sclerosis using cobra venom and
its constituents.

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Cobra’s venom is used to treat …
Back pains Menstrual pains
HeadachesArthritis

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Cobroxin topical gelCobroxin oral sprayNyloxin topical gel

14. Therapeutic Uses of
Hemotoxins
• Hemotoxins target the circulatory system. These contain anti-
clotting activity.
• The protein ‘Ancrod’ which is present in hemotoxins prevent
clotting compounds from functioning correctly, which causes
uncontrollable bleeding.
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15. In Heart attacks:
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• Ancrod seems able to dissolve the blood clots that cause stroke
for as long as 6 hours after stroke symptoms start. Ancrod can also
prevent new blood clots from forming.

16. Eptifibatide Tirofiban
• Both of these medicines are used as a treatment for
minor heart attacks and severe chest pain.
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17. In Hypertension
• Peptides in snake venoms have the potency to prevent a
compound called angiotensin – converting enzyme (ACE).
• Captopril which is derived from snake venom was the first orally
active ACE inhibitory antihypertensive.
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18. Therapeutic Uses of
Cytotoxins
 Cytotoxity
 Inhibition of
– platelet aggregation
– Cardiac arrest
– Hemolysis
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Cytotoxic refers to a substance or process which results
in cell damage or cell death. Cytotoxins exhibit various
physiological effects as

19. In cancer treatment...
Cytotoxic effects of snake venom have
potential to degrade/destroy tumor cells.
These may treat
Breast cancer
Ovarian cancer
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20. • According to recent study, snake venom extracted from
Walterinessia aegyptia alone or in combination with silica nano-
particles can decrease the proliferation of human breast carcinoma
cell line.
• The snake venom toxin from Vipera lebentina turnica induces
apoptotic cell death of ovarian cancer cells.
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• According to a news published in a journal
(Popular science), an Irish company is using
American rattle snake venom to test its anti-
cancer potential. They isolated a protein called
“Disintegrin” from rattle snake venom that causes
malignant cancer cell to commit suicide. This
company has developed a venom-derived drug
called CB24 and started testing it on humans in
October’11.

22. What are Disintegrins?
• Disintegrins are nonenzymatic proteins that inhibit cell-cell
interactions, cell matrix interactions, and may have potential
in the treatment of cancer.
• The disintegrin protein in snake venom, when injected into
cancer cells, binds the outside of the cell via these integrin
receptors and doesn't allow the cell to communicate with
surrounding cells.
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Disintegrins
Integrin receptor

23. Adverse Effects
 Headaches
 Stomach upset
 Allergic reactions
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24. Conclusion
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25. References
 An Interview with Paul F. Reid, PhD. Co-founder and the CEO of
ReceptoPharm, a Nutra Pharma drug discovery company.
 Biologybiozine.com/making-medicine-from-snake-venom/2081.
 www.pharmainfo.net/.../snake-venom-protein-a-wonderful-
medicine-in-...
 www.snakes-uncovered.com/Cytotoxic_Venom.html
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26. Thank You..!
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