Aminoglycosides are potent bactericidal antibiotics that provide strong coverage against aerobic, gram-negative and gram-positive bacteria through rapid concentration-dependent killing and post-antibiotic effects. They are used to treat severe urinary, intra-abdominal, and sepsis infections, but their major limitation is nephrotoxicity and ototoxicity cascades as described in the cited studies from 1986 and 1999.

1. Aminoglycosides Potent bactericidal antibiotics

2. Aminoglycosides Strong Aerobic, gram-negative and gram-positive bacterial coverage Rapid concentration-dependent killing and post-antibiotic effect Used in the treatment of severe infections of urinary, intra-abdominal and sepsis etc. But,

3. Major limitation

4. Aminoglycosidenephrotoxicity cascade Amer J Med 1986;80:105-114

5. Antimicrob Agents Chemother 1999;43:1003-12

6. AminoglycosideOtotoxicity cascade