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Home Tonometer
                     The University of Arizona

                          Eniko Enikov - PI
                        Vasco Polyzoev – EL
                       Emre Toker – Mentor
             Gholam Peyman, MD co-founder/co-inventor
                  (and 11 customers we talked to)




12/14/2011
The ICORP Team
             • Eniko T. Enikov – PI
               - PhD, Assoc. Professor in Mechanical
                Engineering
                - co-Inventor

             • Vasco Polyzoev – EL
               - PhD, Post-Doc Research Associate in
                Mechanical Engineering




             • Emre Toker – Mentor
               - Angel Investor
12/14/2011
The Technology
• Self-performed, non-invasive (over the eyelid)
  tactile tonometry device for glaucoma
  patients




12/14/2011
Home-use serial tonometry
             Value Proposition
   Glaucoma : if you are over 40,   • Repetitive measurement of
   you might be going blind!        eye pressure indicated for 3.2M
   Do you know your IOP?
                                    glaucoma patients; 1%
                                    utilization despite $81
                                    reimbursement

                                    • Performed each month at
                                    home by the patient  $81 x
                                    3.2M patients x once a month
                                    = $3B in new annual
                                    reimbursement revenue
                                    ($500,000 for average
                                    ophthalmologist)

12/14/2011
Must Have’s
• FDA 510(k) approval – equivalence to gold
  standard
• Acceptance by clinical community (beyond
  FDA approval)
• Continued reimbursement of remote
  interpretation of home tonometry
• Patent issued (US)


12/14/2011
Price
• High volume COGs ~$100

• Price survey of ophthalmologists: ~$315/unit

• $315 x 3.2M patients = $1B total market

• Additional annual reimbursement revenue to
  ophthalmologist per device/patient:
  $81 x 12 months = $972

12/14/2011
Competition



              Diaton - $2500




               Icare - $3500




              Tonopen - $1500
12/14/2011
Initial Idea
• We will make a great home tonometer and every
  glaucoma patient and every ophthalmologist will
  want to have it (at any price)…

• Insurance/Medicare/VA will pay for it too,
  because it will save costs of transporting elderly
  and disabled to eye clinics…

• We can sell it off of our website and handle all
  the transactions, etc… but will allow help from
  distributors

12/14/2011
Initial Business Model Canvas




12/14/2011
Revised Ideas
 (after talking to 8 doctors (phone & in person) and 3 patients (forum))

• We will need the help of doctors to gain acceptance of
  the home tonometer to glaucoma patients

• NOT every ophthalmologist will want to have it
  (definitely NOT at any price)…

• Already an existing reimbursement for serial
  tonometry

• Maybe have a research version for animal research labs
  (extra revenue pre-FDA)


12/14/2011
Business Model Canvas 2




12/14/2011
New Inputs
             (after talking to 5 distribution companies)

• We will need a GAT -
  comparable accuracy to
  get doctors interested in
  our tonometer
• Suggestion to emulate
  hearing aids distribution
  and consign an inventory
  with doctors.
• Patient gets fitted with a
  tonometer in the doctor’s            Key Idea: One tonometer -> fits all !!!

  office.

12/14/2011                           Patent pending
Business Model Canvas 3




12/14/2011
More Inputs
   (after more discussions with 6 doctors and reflecting on operations and
                                partnerships)




12/14/2011
Business Model Canvas 4




12/14/2011
Distribution and Marketing Diagram




12/14/2011
Next Steps
• Develop limited
  clinical evaluation
  using ~50 patients
  and confirm
  correlation with GAT
  and accuracy.
• Seek VC/SBIR
  funding for larger
  clinical evaluation
  and FDA approval

12/14/2011

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Tonometer Final NSF I-Corps presentation

  • 1. Home Tonometer The University of Arizona Eniko Enikov - PI Vasco Polyzoev – EL Emre Toker – Mentor Gholam Peyman, MD co-founder/co-inventor (and 11 customers we talked to) 12/14/2011
  • 2. The ICORP Team • Eniko T. Enikov – PI - PhD, Assoc. Professor in Mechanical Engineering - co-Inventor • Vasco Polyzoev – EL - PhD, Post-Doc Research Associate in Mechanical Engineering • Emre Toker – Mentor - Angel Investor 12/14/2011
  • 3. The Technology • Self-performed, non-invasive (over the eyelid) tactile tonometry device for glaucoma patients 12/14/2011
  • 4. Home-use serial tonometry Value Proposition Glaucoma : if you are over 40, • Repetitive measurement of you might be going blind! eye pressure indicated for 3.2M Do you know your IOP? glaucoma patients; 1% utilization despite $81 reimbursement • Performed each month at home by the patient  $81 x 3.2M patients x once a month = $3B in new annual reimbursement revenue ($500,000 for average ophthalmologist) 12/14/2011
  • 5. Must Have’s • FDA 510(k) approval – equivalence to gold standard • Acceptance by clinical community (beyond FDA approval) • Continued reimbursement of remote interpretation of home tonometry • Patent issued (US) 12/14/2011
  • 6. Price • High volume COGs ~$100 • Price survey of ophthalmologists: ~$315/unit • $315 x 3.2M patients = $1B total market • Additional annual reimbursement revenue to ophthalmologist per device/patient: $81 x 12 months = $972 12/14/2011
  • 7. Competition Diaton - $2500 Icare - $3500 Tonopen - $1500 12/14/2011
  • 8. Initial Idea • We will make a great home tonometer and every glaucoma patient and every ophthalmologist will want to have it (at any price)… • Insurance/Medicare/VA will pay for it too, because it will save costs of transporting elderly and disabled to eye clinics… • We can sell it off of our website and handle all the transactions, etc… but will allow help from distributors 12/14/2011
  • 9. Initial Business Model Canvas 12/14/2011
  • 10. Revised Ideas (after talking to 8 doctors (phone & in person) and 3 patients (forum)) • We will need the help of doctors to gain acceptance of the home tonometer to glaucoma patients • NOT every ophthalmologist will want to have it (definitely NOT at any price)… • Already an existing reimbursement for serial tonometry • Maybe have a research version for animal research labs (extra revenue pre-FDA) 12/14/2011
  • 11. Business Model Canvas 2 12/14/2011
  • 12. New Inputs (after talking to 5 distribution companies) • We will need a GAT - comparable accuracy to get doctors interested in our tonometer • Suggestion to emulate hearing aids distribution and consign an inventory with doctors. • Patient gets fitted with a tonometer in the doctor’s Key Idea: One tonometer -> fits all !!! office. 12/14/2011 Patent pending
  • 13. Business Model Canvas 3 12/14/2011
  • 14. More Inputs (after more discussions with 6 doctors and reflecting on operations and partnerships) 12/14/2011
  • 15. Business Model Canvas 4 12/14/2011
  • 16. Distribution and Marketing Diagram 12/14/2011
  • 17. Next Steps • Develop limited clinical evaluation using ~50 patients and confirm correlation with GAT and accuracy. • Seek VC/SBIR funding for larger clinical evaluation and FDA approval 12/14/2011