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NEUROIMAGING IN PSYCHIATRY Moderator: Dr. J.N. Das Assistant Professor Assam Medical College & Hospital 10 th  September 2009 Presenter: Dr. Santanu Ghosh Post Graduate Student
Overview of Presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Introduction ,[object Object],[object Object],[object Object],[object Object]
Key questions for  psychiatric neuroimaging:  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Milestones of Neuroimaging: 1946 MR phenomenon - Bloch & Purcell  1952 Nobel Prize - Bloch & Purcell  1950--1970  NMR developed as analytical tool  1963 First instance of SPECT using the Anger Camera - Kuhl and Edwards  1972 Computerized Tomography  (Godfrey Hounsfield, Allan McLeod Cormack, 1979- Nobel Prize-Medicine ) 1973 Backprojection MRI - Lauterbur  1983 Compton Camera for SPECT - Manbir Singh and David Doria  1985 DTI- Le Bihan D & Breton   E  1986  Gradient Echo Imaging ,NMR Microscope  1987 MR Angiography - Dumoulin  1991 Nobel Prize - Ernst  1992 Functional MRI (fMRI)  1994 Hyperpolarized  129 Xe Imaging  2003 Nobel Prize - Lauterbur & Mansfield
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Basics- CT ,[object Object],[object Object],[object Object]
Basics- CT  contd… ,[object Object],[object Object]
Basics - MRI ,[object Object],[object Object],[object Object]
Basics - MRI ,[object Object],[object Object],[object Object],[object Object],[object Object]
Basics - MRI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Basics - MRI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Basics - MRI ,[object Object],[object Object],[object Object],[object Object],[object Object]
Basics - MRI ,[object Object],[object Object],[object Object],[object Object],[object Object]
Basics - MRI ,[object Object],[object Object],[object Object],[object Object]
T1- weighted MR  T2- weighted MR  CT Scan
Basics - fMRI ,[object Object],[object Object],[object Object],[object Object]
Basics - fMRI ,[object Object],[object Object]
Basics-MRS ,[object Object],[object Object]
Basics-PET ,[object Object],[object Object],[object Object],[object Object]
Basics-PET ,[object Object],[object Object],[object Object]
Basics-PET ,[object Object],[object Object]
Basics-SPECT ,[object Object],[object Object],[object Object],[object Object]
Basics-SPECT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Basics-SPECT ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Basics-DTI(Diffusion Tensor Imaging)
DTI
IMAGING IN OCD
sMRI in OCD ,[object Object],[object Object],[object Object],[object Object]
SPECT in OCD ,[object Object],[object Object],[object Object]
SPECT in OCD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PET in OCD ,[object Object],[object Object]
Meta-Analysis of PET and SPECT in OCD ,[object Object],[object Object],[object Object],[object Object],Whiteside SP et al (2004) Psychiatry Res. 132:69-79.
MRS in OCD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Sumitani S et al (2007) Psychiatry Res. 154:85-92
DTI Data OCD ,[object Object],[object Object],[object Object],Yoo SY et al (2007) Acta Psychiatr Scand. 116:211-9 .
IMAGING IN DEPRESSION
fMRI in Depression ,[object Object],[object Object],[object Object]
SPECT in Depression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PET in Depression  Contd.. ,[object Object],[object Object],[object Object],[object Object]
Imaging in Dementia
PURPOSES OF IMAGING IN DEMENTIA ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Alzheimr’s Disease (AD) ,[object Object],[object Object],[object Object],[object Object],[object Object]
sMRI- Alzehimer’s Disease ,[object Object],[object Object],[object Object]
[object Object],Normal ALZHEIMER’S DISEASE
ALZHEIMER’S DISEASE  NORMAL
[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Frontotemporal dementia
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
SPECT-Vascular Dementia ,[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
MRS- Dementia ,[object Object],[object Object],[object Object]
MR Perfusion study in Alzheimer’s disease A characteristic bilateral temporoparietal decrease in blood flow is noted.
[object Object],[object Object],[object Object],[object Object],PET:  Reduced uptake of  glucose in temporal  lobe.  ,[object Object],[object Object],MR SPECTROSCOPY:  -Decrease in  NAA. -Increase in  myoinositol.   Alzheimer’s disease
IMAGING IN ANXIETY DISORDER
sMRI- Anxiety Disorder ,[object Object],[object Object],[object Object]
IMAGING IN SCHIZOPHRENIA
[object Object],[object Object],Circuitry Breakdown in Schizophrenia
Circuitry Breakdown in Schizophrenia ,[object Object],[object Object],[object Object]
Circuitry Breakdown in Schizophrenia ,[object Object],[object Object],[object Object]
CT- Schizophrenia ,[object Object],[object Object],[object Object]
sMRI- Schizophrenia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
sMRI- ADHD ,[object Object],[object Object],[object Object]
sMRI- Autism ,[object Object],[object Object],[object Object],[object Object],[object Object]
PET- Autism ,[object Object]
Psychotropic Drugs & fMRI ,[object Object],[object Object],[object Object]
Conclusion ,[object Object],[object Object],[object Object],[object Object]
Bibliography ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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Neuroimaging in psychiatry

  • 1. NEUROIMAGING IN PSYCHIATRY Moderator: Dr. J.N. Das Assistant Professor Assam Medical College & Hospital 10 th September 2009 Presenter: Dr. Santanu Ghosh Post Graduate Student
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  • 5. Milestones of Neuroimaging: 1946 MR phenomenon - Bloch & Purcell 1952 Nobel Prize - Bloch & Purcell 1950--1970 NMR developed as analytical tool 1963 First instance of SPECT using the Anger Camera - Kuhl and Edwards 1972 Computerized Tomography (Godfrey Hounsfield, Allan McLeod Cormack, 1979- Nobel Prize-Medicine ) 1973 Backprojection MRI - Lauterbur 1983 Compton Camera for SPECT - Manbir Singh and David Doria 1985 DTI- Le Bihan D & Breton E 1986 Gradient Echo Imaging ,NMR Microscope 1987 MR Angiography - Dumoulin 1991 Nobel Prize - Ernst 1992 Functional MRI (fMRI) 1994 Hyperpolarized 129 Xe Imaging 2003 Nobel Prize - Lauterbur & Mansfield
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  • 16. T1- weighted MR T2- weighted MR CT Scan
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  • 27. DTI
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  • 63. MR Perfusion study in Alzheimer’s disease A characteristic bilateral temporoparietal decrease in blood flow is noted.
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  • 65. IMAGING IN ANXIETY DISORDER
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