SPIO Particle NO Production and Uptake in Macrophages
1. Figure (1): NO production by Dextran coated vs. Lipid coated
SPIO particles in Macrophages-24 h
SPIO-4SPIO-2 SPIO-3 Control
0.0
0.1
0.2
0.3
SPIO-4
SPIO-2
SPIO-3
Control
OD550(Nitritelevel)
3. Figure (3) A: macrophages harvested from mice injected
with FITC-SPIO show intracellular fluorescence. The same
panel stained with DAPI to show nuclear stain and viability.
B: Circulating monocyte, shows iron particles (arrow),
after the injection of SPIO.
A B
4. Dark (negatively enhanced) aortic wall, full of iron particles
Bright aortic lumen and wall without negative enhancement
and no significant number of iron particles in pathology
Before Injection After Injection (5 Days )
Apo E
Deficient
mouse
C57B1
(control)
mouse
Figure 7:
