1. EBT and Coronary Artery CalciumEBT and Coronary Artery Calcium
Coronary Artery CalciumCoronary Artery Calcium ISIS AtherosclerosisAtherosclerosis
There areThere are NONO false positive calcium measuresfalse positive calcium measures
by EBT [i.e. ALL calcium is plaque]by EBT [i.e. ALL calcium is plaque]
Establishes a diagnosis ofEstablishes a diagnosis of
coronary atherosclerosiscoronary atherosclerosis
2. Coronary Calcium Area by EBT andCoronary Calcium Area by EBT and
Coronary Artery Plaque AreaCoronary Artery Plaque Area
0
2
4
6
8
10
12
14
16
0 2 4 6 8
Square Root Sum of Calcium Areas
SquareRootSumof
PlaqueAreas
Rumberger, Circ 1995:92:2157-62
n = 38n = 38
r = 0.90r = 0.90
p < .001p < .001
3. No. of coronary segments/pt. with plaques (IVUS)
0 1 2 3 4 5 6 7
No. of calcified
coronary
segments/pt.
(EBCT)
0
1
2
3
4
5
6
7
Y = -0.67 + (0.90 * X)
r = 0.86
p < 0.0001 N = 40 patients
total of 222 coronary
segments examined
Acute Coronary Syndrome and Non-Obstructive CADAcute Coronary Syndrome and Non-Obstructive CAD
# of segments with EBT calcium vs. # of segments with any plaque# of segments with EBT calcium vs. # of segments with any plaque
Schmermund et alSchmermund et al
AJC 1998; 81:AJC 1998; 81:
141-146141-146
4. EBT and Coronary Artery CalciumEBT and Coronary Artery Calcium
Define the extent of disease? YESDefine the extent of disease? YES
The amount of calciumThe amount of calcium correlates DIRECTLYcorrelates DIRECTLY toto
the amount of measurable coronary disease by:the amount of measurable coronary disease by:
1) direct histopathologic comparison1) direct histopathologic comparison
2) with intravascular ultrasound2) with intravascular ultrasound