4. Structural damage preceed functional loss
About 50% of RNFL has to be lost*
Window of about 6years
Dr. Harry Quigley. Kerrigan- Baummen, Quigley et al. IOVS 2000
7. Optical
Coherance
Tomography
8
Normal scan:
Very unlikely there is
glaucoma
Physiological cupping
from early glaucoma
Diagnose and follow up
pre perimetric glaucoma
Monitor progression
confirm whether VF
defect is real or an
artifact
8. 9
Various OCT instruments are available Generations
- Nadik
- Topcon
- Zeiss
- Optovue
- Heidelberg
- TD-OCT
- SD-OCT
36. Cirrus OCT
40
284 Volunteers
46.5 years
Caucasians 43%
Asians 24%
A America 18%
Hispanic 12%
mixed ethnicity 6%
Indian 1%
Age
18–29
30–39
40–49
50–59
60–69
>70 years
Refractive error
− 12 to + 8D
Chronic progressive optic neuropathy associated with accelerated apoptosis of the RGCs , resultingin………… that may or may not be associated with IOP rise”.
As we all know structural damage preceeds functional loss and abt 50% of RNFL has to be lost before VF defect becomes apparent and RNFL thinning may precede appearance of VF defect by almost 6years. So there is a large window for pts we can intervene and prevent or delay any visual field loss from occurring in potential glaucoma pts.
Pertaining to glaucoma OCT very help ful
Glaucoma as we all know effects three areas in posterior segment of eye
best quality scans have signal strength greater than 8 (minimum acceptable scan > 6).
Machine algorithm identifies termination of bruchs membrane as the disc edge
Retina is mostly NFL. Large enough to avoid the edge of ONH. Large enough to avoid peripapillary atrophy
Glaucoma as we all know effects three areas in posterior segment of eye
Segmentation error: Machine cannot differenciate where the different layers of the retina are and it just shows everything as black cos machine is not able to delineate where the nerve fiber layer is. So areas where it cannot delineate it shows RNFL thickness as zero. Which shows as black in thickness map. If these areas happens to involve part of measurement circle we can see graph value goin down to 0 in TSNIT plot
People are referred to me for glaucoma diagnosis when there is absolutely no glaucoma, simply because an OCT scan was abnormal. And I’m seeing patients who have glaucoma but were told they did not have any disease because their OCT results appeared to be normal.
Red disease is when the OCT mistakenly indicates that something is abnormal; green disease is when the OCT data shows no sign of abnormality, but the eye is, in fact, in trouble.
Normative data has limitations
The macular and optic disc LSO fundus images are registered and combined.
The RNFL and GCA deviation maps are registered and combined.
Glaucoma diagnosis depends on triad of – raised IOP, ONH changes and VF limitations
OCT has added fourth dimension to glaucoma diagnosis
Kim N.R, H et al, J. Glaucoma 2012; 21: 116.
Stein D M et al : Ophthalmology, 2006; 113:985