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Interpretation of OCT
Dr Shylesh Dabke
Glaucoma Consultant
AEH, Tirunelveli
1
Application in Glaucoma
3
ONH Cupping VF Abnormalities
RNFL Thinning
“may or may not be associated with
IOP rise”
4
RNFL Thinning
Structural damage preceed functional loss
About 50% of RNFL has to be lost*
Window of about 6years
Dr. Harry Quigley. Kerrigan- Baummen, Quigley et al. IOVS 2000
6
“Is it Glaucoma?”
7
“Whether it is not Glaucoma?”
Optical
Coherance
Tomography
8
Normal scan:
Very unlikely there is
glaucoma
Physiological cupping
from early glaucoma
Diagnose and follow up
pre perimetric glaucoma
Monitor progression
confirm whether VF
defect is real or an
artifact
9
Various OCT instruments are available Generations
- Nadik
- Topcon
- Zeiss
- Optovue
- Heidelberg
- TD-OCT
- SD-OCT
10
Macula ONH
Ganglion
cell
ONH
&
RNFL
11
12
13
Center
15
16
17
18
19
20
21
22
23
24
Macula ONH
Ganglion
cell
Analysis
ONH
&
RNFL
25
“Ganglion Cell Analysis”
26
29
Artifacts
Involuntary saccade artifact
Blink Artifacts
Floaters and vitreous opacity
Segmentation Error
30
Involuntary saccade artifact
Blink Artifacts
Floaters and vitreous opacity
Segmentation Error
Artifacts
31
Blink Artifacts
32
Involuntary saccade artifact
Blink Artifacts
Floaters and vitreous opacity
Segmentation Error
Artifacts
33
Floaters and vitreous opacity
34
Involuntary saccade artifact
Blink Artifacts
Floaters and vitreous opacity
Segmentation Error
Artifacts
35
Segmentation Error
36
37
Error
In reading
OCT Scan
When we ignore the sensitivity and specificity of OCT
Concept of
Red DiseaseGreen Disease
38
“I bark at everyone..
cant go wrong that way”
Cirrus OCT
40
284 Volunteers
46.5 years
Caucasians 43%
Asians 24%
A America 18%
Hispanic 12%
mixed ethnicity 6%
Indian 1%
Age
18–29
30–39
40–49
50–59
60–69
>70 years
Refractive error
− 12 to + 8D
“Guided Progression Analysis”
42
“PanoMap Analysis”
Glaucoma
IOP
VFONH
OCT
44
“Thank You”

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Interpretation of OCT(Glaucoma)

Editor's Notes

  1. Chronic progressive optic neuropathy associated with accelerated apoptosis of the RGCs , resultingin………… that may or may not be associated with IOP rise”.
  2. As we all know structural damage preceeds functional loss and abt 50% of RNFL has to be lost before VF defect becomes apparent and RNFL thinning may precede appearance of VF defect by almost 6years. So there is a large window for pts we can intervene and prevent or delay any visual field loss from occurring in potential glaucoma pts.
  3. Pertaining to glaucoma OCT very help ful
  4. Glaucoma as we all know effects three areas in posterior segment of eye
  5. best quality scans have signal strength greater than 8 (minimum acceptable scan > 6).
  6. Machine algorithm identifies termination of bruchs membrane as the disc edge
  7. Retina is mostly NFL. Large enough to avoid the edge of ONH. Large enough to avoid peripapillary atrophy
  8. Glaucoma as we all know effects three areas in posterior segment of eye
  9. Segmentation error: Machine cannot differenciate where the different layers of the retina are and it just shows everything as black cos machine is not able to delineate where the nerve fiber layer is. So areas where it cannot delineate it shows RNFL thickness as zero. Which shows as black in thickness map. If these areas happens to involve part of measurement circle we can see graph value goin down to 0 in TSNIT plot
  10. People are referred to me for glaucoma diagnosis when there is absolutely no glaucoma, simply because an OCT scan was abnormal. And I’m seeing patients who have glaucoma but were told they did not have any disease because their OCT results appeared to be normal. Red disease is when the OCT mistakenly indicates that something is abnormal; green disease is when the OCT data shows no sign of abnormality, but the eye is, in fact, in trouble.
  11. Normative data has limitations
  12. The macular and optic disc LSO fundus images are registered and combined. The RNFL and GCA deviation maps are registered and combined.
  13. Glaucoma diagnosis depends on triad of – raised IOP, ONH changes and VF limitations OCT has added fourth dimension to glaucoma diagnosis
  14. Kim N.R, H et al, J. Glaucoma 2012; 21: 116. Stein D M et al : Ophthalmology, 2006; 113:985