Basic Concept of Disaster and Disaster Risk .pdf

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Senior high school course on Disaster Readiness & Risk Reduction

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Basic Concept of Disaster and Disaster Risk .pdf

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The efficient delivery of therapeutic agents to tumor sites remains a significant challenge in cancer treatment. Nano-carriers have emerged as promising vehicles for targeted drug delivery due to their ability to enhance drug solubility, prolong circulation time, and minimize systemic toxicity. This review provides a comprehensive overview of active and passive targeting strategies employed to improve the efficiency of nano-carriers in reaching and accumulating at tumor sites. Active targeting utilizes ligands or antibodies to specifically bind to receptors overexpressed on tumor cells, while passive targeting exploits the unique characteristics of the tumor microenvironment, such as leaky vasculature and impaired lymphatic drainage, to enhance accumulation. The synergistic combination of active and passive targeting strategies holds great potential for optimizing drug delivery to tumors while minimizing off-target effects. In-depth understanding of these strategies is crucial for the rational design and development of nano-carriers tailored for enhanced efficacy in cancer therapy. Keywords: Nano-carriers, tumor targeting, active targeting, passive targeting, drug delivery, cancer therapy

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