Tortora PRINCIPLES OF ANATOMY AND PHYSIOLOGY - Tortora - 14th Ed.pdf
Depression Symptoms Causes And Treatment Options.pdf
1. Depression Symptoms Causes And Treatment Options
Depression is a complex of psychological and physical symptoms. Low mood level or sadness is often the
most prominent symptom. The common property of these symptoms is a decreased activity level in parts
of the brain.
THE SYMPTOMS OF DEPRESSION
Depression may give one or more of these symptoms:
-Low mood level or sadness.
-Lack of joy or interest in activities that were joyful before.
-Pessimism.
-Feel of guilt of something without any substantial reason to feel so.
-Inferiority thoughts.
-Irritability.
-Slowness in the thought process.
-Slowness in interpreting sensorial stimuli.
-Slowness of digestion or other internal physical processes, and symptoms caused by this slowness, for
example inflated stomach, constipation or difficulties by urination.
-Slow physical reactions.
Depression can be a mild disease that only causes some annoyance in the daily life, but can also get very
serious and make a person totally unable to work and unable to participate in social life. By depression of
some severity, there is also a greater risk of suicide.
Depression Age
Depression can occur in all age classes. In teenagers lack of interest in school work, withdrawal from
social life and difficult mood can be signs of depression
2. THE PHYSIOLOGICAL CHANGES THAT PRODUCE THE SYMPTOMS.
By depression there is a decreased number of neurotransmitters in parts of the central nervous system,
mainly deficiency of serotonin, but also to some extend of noradrenalin, acetylcholine, dopamine or gamma-
amino-butyric acid (GABA), or the nerve cells do not react properly by stimulation from
neurotransmitters. A neurotransmitter is a signal substance that transmits the nerve signal through the
junctions between two nerve cells.
Serotonin and noradrenalin cause nerve cells to send impulses along to other nerve cells, and thus increase
the activity in the brain. Deficiency of these substances causes slowness in parts of the brain, and that
again causes the depressive symptoms.
The role of GABA is the opposite, namely to slow down some nerve impulses, mainly those causing anxiety
and panic response. Lack of GABA causes higher anxiety and easier panic response. Yet, lack of this
transmitter also seems to cause depressive symptoms. This is because a too high activity in some brain
processes may slow down other processes.
There are many causes and subtypes of depression
TYPES OF DEPRESSION
Depression is often divided into subtypes according to exhibited symptoms.
1. Mono-polar depression and dysthymic disorder
By mono-polar depression there are pure depressive symptoms. Mild cases of mono-polar disorder that do
not affect a person’s ability to work and to participate in social activities are often called dysthymic
disorder.
2. Bipolar disorder (manic-depressive disease) and cyclothymic disorder
In this condition there are periods with symptoms of depression – the depressive phase, alternating with
periods of elevated mood level with increased mental and physical activity – the manic phase. In the manic
phase, the affected person also sleeps poorly and has concentration difficulties. A mild form of this
disease is called cyclothymic disorder.
3. Manic disorder
This condition is characterized by abnormally elevated mood, by unrealistic optimism, by lack of sleep and
by hyperactive behaviour. Many psychiatrists think that this disorder is simply the same disease as bipolar
disorder where the depressive face has not yet occurred.
4. Depression with mainly physical symptoms
Sometimes the physical symptoms of depression are alone or dominant, as for example: Digestive
problems, constipation, difficulties with urination, slow response to sensorial stimuli or slow physical
reactions.
CAUSES OF DEPRESSION
Two or more factors can have an effect simultaneously to cause depression. Depression can be an
independent disease, or a part of other disease. Depression is also divided into different subtypes
according to cause.
3. 1. Reactive depression
This disease is simply a result from psychological stress, physical struggle or mental straining without
proper rest or sleep over a long time period. The straining will simply wear out the nervous system or
deplete the organism from nutrient necessary for the nervous system to work properly.
2. Endogenous depression
When there has not been any period of stress, straining or lack of rest that can explain the condition, the
condition is often called endogenous depression. Inheritance is thought to be a part of the cause.
3. Depression by physical disease
Depression or depressive symptoms may be a symptom of physical disease. This is perhaps the most
common cause of depression. Generally, there are three categories of diseases that give depression:
Diseases often associated with depression are: Heart disease, Parkinson’s disease, stroke, hypertension or
Cushing’s syndrome.
Mononucleosis or flu may trigger depression that continues after the infection has gone.
By lack of thyroid hormones, hypothyroidism, the metabolism in the whole body is slowed down, including
the production of neurotransmitters in the brain. Therefore, depression is an important symptom of
hypothyroidism.
4. Depressive symptoms as a consequence of unsound lifestyle
A general unsound lifestyle with too less exercise, too much of stimulants like alcohol, coffee or tea, too
less of important nutrient and too much of sugar and fat may give depressive symptoms, as well as physical
problems.
5. Postnatal depression
Women will often have a period of depression after pregnancy and birth of the baby Pregnancy and berth
is physically and mentally exhausting, and may drain the body for nutrient. This in turn can cause
depressive symptoms
6. Seasonal effective disorder
Depression can occur in cold and dark periods of the year and go away in warm and light periods. Light
stimulates brain activity, and lack of light is a causative factor.
TREATMENT OF DEPRESSION
Serious or prolonged depression is often treated with anti-depressive medication. Medicines used against
depression generally increase the level of neurotransmitters like serotonin in the central nervous system,
or they mimic the neurotransmitters.
4. The medications mostly used today increase the serotonin concentration by decreasing the removal of
serotonin from the space around nerve cells. Examples of this medication type are: Fluoxetine (Prozac),
fluvoxamine (Luvox), paroxetine (Paxil), escitalopram (Lexapro, Celexa), sentraline (Zoloft).
By bipolar disorder in the manic face, heavy tranquilizers (neuroleptica) are used to stop the manic
symptoms. By bipolar disorder, lithium salts are sometimes used to stabilize the condition, and prevent
new outbreak of depressive or manic faces.
Psychotherapy is sometimes used by depression, usually in combination with medication.
Sometimes serious depression is treated by applying electric shock through the head, electroconvulsive
therapy. The shock induces epileptic eruption of nerve signals through the brain and this gives cramps
throughout the body. The cramps are alleviated or stopped by applying anaesthesia before the electroshock.
This form of treatment is controversial, since it can cause memory loss and is suspected of causing brain
damage. The possibility of brain damage is however denied by most psychiatrists.
By seasonal depression, light therapy may be useful.
Adjustment of lifestyle should always be considered by depression or depressive symptoms. Lifestyle
measures can sometimes be enough to cure depressive symptoms before a serious depression develop.
Lifestyle adjustments can be:
– To slow down a stressful life with too much work or activities.
– Enough rest and sleep.
– A good diet with enough of necessary nutrients
– Some physical exercise.
– Meditation.
– Supplement of vitamins, minerals, antioxidants, lecithin, amino acids and essential fatty acids.
– Stimulants like coffee or tea may help against depressive feelings in moderate amount. However, if you
are a heavy user of these stimulants, you should cut down on your consumption.
There exist nutritional products in the marked to help against depressive symptoms. These contain
ingredients that the brain uses as building blocks for neurotransmitters, for example amino acids and
lecithin. They also often contain vitamins and minerals that the brain uses as tools to produce
neurotransmitters, especially vitamin B6.
Supplements may further contain herbal extracts that trigger higher brain activity much like anti-
depressive medications, but may have fewer side effects