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DNA: Replication and Mutation
What is DNA?
 DNA = deoxyribonucleic acid
 DNA is the “blueprint” for the cell
contains the instructions that tells the
cell how to do things and what to make
 DNA is like blueprints for making a city, which
in this case is the cell
RED => COPY INTO NOTEBOOK
Amoeba Cell
What is DNA made of?
 DNA is made up of 4 bases:
– Adenine (A), Thymine (T), Cytosine (C), Guanine (G)
Rules for DNA Bases:
1. A pairs with T
2. G pairs with C
“Chargaff’s Rules”
Structure of DNA
 DNA is made up of two
strands (double
stranded)
 Each strand has the
bases connected to a
PHOSPHATE
BACKBONE
 The two strands wrap
around each other in a
winding staircase
manner (helix)
Models of DNA
ACTUAL Pictures of DNA
DNA Replication
 In order for you to survive,
your cells need to replicate
themselves. In order for
them to do that, they need
to replicate their DNA
 Every cell in your body has
the same DNA, because
every time one of your cells
divides, it makes a copy of
its DNA to give to the new
daughter cells
How does DNA replicate?
 The DNA is unzipped and the original strands
are used to help make the new molecules –
See Demonstration
What are mutations?
 MUTATIONS are any
changes in the
sequence of bases of
DNA
Mutations DO NOT
lead to this
Mutations COULD
lead to this
Colon cancer cells
How do mutations occur?
 Sometimes during replication,
the cell makes a mistake and
adds the wrong base
 When the cell replicates its DNA
again, the two strands that are
produced are no longer exactly
the same
 This usually will cause the new
cell to die, but sometimes it can
cause the cell to divide when it is
not supposed to  cancer
How do mutations occur?
Replication
What can cause mutations to happen
more often?

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DNA and RNA: The Comparison of DNA and RNA.

  • 2. What is DNA?  DNA = deoxyribonucleic acid  DNA is the “blueprint” for the cell contains the instructions that tells the cell how to do things and what to make  DNA is like blueprints for making a city, which in this case is the cell RED => COPY INTO NOTEBOOK Amoeba Cell
  • 3. What is DNA made of?  DNA is made up of 4 bases: – Adenine (A), Thymine (T), Cytosine (C), Guanine (G) Rules for DNA Bases: 1. A pairs with T 2. G pairs with C “Chargaff’s Rules”
  • 4. Structure of DNA  DNA is made up of two strands (double stranded)  Each strand has the bases connected to a PHOSPHATE BACKBONE  The two strands wrap around each other in a winding staircase manner (helix)
  • 7. DNA Replication  In order for you to survive, your cells need to replicate themselves. In order for them to do that, they need to replicate their DNA  Every cell in your body has the same DNA, because every time one of your cells divides, it makes a copy of its DNA to give to the new daughter cells
  • 8. How does DNA replicate?  The DNA is unzipped and the original strands are used to help make the new molecules – See Demonstration
  • 9. What are mutations?  MUTATIONS are any changes in the sequence of bases of DNA Mutations DO NOT lead to this Mutations COULD lead to this Colon cancer cells
  • 10. How do mutations occur?  Sometimes during replication, the cell makes a mistake and adds the wrong base  When the cell replicates its DNA again, the two strands that are produced are no longer exactly the same  This usually will cause the new cell to die, but sometimes it can cause the cell to divide when it is not supposed to  cancer
  • 11. How do mutations occur? Replication
  • 12. What can cause mutations to happen more often?