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Data Surrealism In Times Of FAIR Data
A Pragmatic Approach To Generate More Value With Data
Hans Constandt
hans@ontoforce.com
www.ontoforce.com
+32 (0)477 566 102
+1 (415) 996 8988
TWITTER: hconstandt
LINKEDIN: hansconstandt
hconstandt
How it All Started
Source - IDC
hconstandt
Minimizing Big Data Complexity
The Data Tsunami
Source - IDC
165 ZETTABYTES BY 2025
hconstandt
This is what data looks like
THE PROBLEM
hconstandt
PATIENT-CENTRIC PRECISION MEDICINE
CREATES LARGE VOLUMES OF DATA
Health Data
300 million books
2020 Medical Data
Doubles every 73d
Monitoring
1K Readings per Sec
Wearables
44ZB by 2020
hconstandt
Providing a Complete, Single
View of Trusted Data
Helping Patients
hconstandt
Big Data 4 V’s
DATA VARIETY & DATA VERACITY
VOLUME VELOCIT Y VARIE T Y VERACIT Y
Data
at rest
Data
in motion
Data in
many forms
Data
In doubt
hconstandt
Building a Linked
Data Fabric
PATENTED
hconstandt
hconstandt
hconstandt
hconstandt
hconstandthconstandtconfidential and not to be shared without consent
If I had an hour to
solve a problem and
my life depended on it,
I would use the first 55
minutes determing
the proper
question to ask
ALBERT EINSTEIN
hconstandt
hconstandt
A Self-Service and Collaborative
Data Platform for Business Users
Saved € 120M in 13 min
Management of Corporate Data Assets
INSUFFICIENT MANAGEMENT OF INTANGIBLE RESOURCES
Source https://www.gartner.com/smarterwithgartner/understanding-the-chief-data-officer-role/
Components of S&P 500 market value
hconstandt
The Promise
DATA LAKE
hconstandt
DATA SWAMP
Data Lake Typical Realisation
hconstandt
You don’t need to
be a genius to do
Data analytics.
Data
integration is
the key
hconstandt
the most successful project that uses deep
neural networks in there company or group,
10% or less improvement was found
over more traditional methods?’
At the Bio-IT World conference 2019
53% of the company’s indicated that…
AI REALITY CHECK
hconstandt
Poor sales ...
IBM Watson Health
hconstandt
Machine
LearningData
hconstandt
2018: enabling AI/ML functionality automating the fabric.
Round A: € 4,3M
hconstandt
AI
Big Data Fabric 2.0 Reference Architecture
hconstandt
Source: Forrester
Solve scalability issues associated with massive
linking & inferencing during Data Ingestion
User friendliness of ETL process creation
Transparency / communicability / auditability of ETL
Data Quality Control / validation of data & process
Auditability
Data Quality
Challenges
User friendliness
Scalability
hconstandt
Streamlining Data through
Pipelines for Faster Analysis
hconstandt
Show me the Money hconstandt
FAIR DATA
Findable Accessible Interoperable Reusable
hconstandt
FAIR enough to bring value
hconstandt
ROI of $3.1M
100 USERS
SITE LICENSE
Saving $134M
ENTERPRISE LICENSE
Saving $807M
hconstandt
hconstandt
ROI & Calculate Value
Solomon Nwaka & Robert G. Ridley. Nature Reviews
Drug Discovery 2003
Time squeezing in Discovery
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
IT = Identifiied Target
PT = Prioritized Target
VT = Validated Target
LM = Lead Molecule
CM = Candidate Molecule
hconstandt
Solomon Nwaka & Robert G. Ridley. Nature Reviews
Drug Discovery 2003
Time squeezing in Discovery
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
IT = Identifiied Target
PT = Prioritized Target
VT = Validated Target
LM = Lead Molecule
CM = Candidate Molecule
hconstandt
$3.1M
hconstandt
ROI & Calculate Value
Solomon Nwaka & Robert G. Ridley. Nature Reviews
Drug Discovery 2003
Time squeezing in Discovery
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
IT = Identifiied Target
PT = Prioritized Target
VT = Validated Target
LM = Lead Molecule
CM = Candidate Molecule
hconstandt
Solomon Nwaka & Robert G. Ridley. Nature Reviews
Drug Discovery 2003
Time squeezing in Discovery
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
IT = Identifiied Target
PT = Prioritized Target
VT = Validated Target
LM = Lead Molecule
CM = Candidate Molecule
hconstandt
Solomon Nwaka & Robert G. Ridley. Nature Reviews
Drug Discovery 2003
Time squeezing in Discovery
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
IT = Identifiied Target
PT = Prioritized Target
VT = Validated Target
LM = Lead Molecule
CM = Candidate Molecule
hconstandt
Solomon Nwaka & Robert G. Ridley. Nature Reviews
Drug Discovery 2003
Time squeezing in Discovery
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT = Identifiied Target
PT = Prioritized Target
VT = Validated Target
LM = Lead Molecule
CM = Candidate Molecule
IT PT VT LM CM
Target
Identification
Target
Selection
Target
Validation
Lead
Identification
Lead
Optimization
Preclinical
Development
IT PT VT LM CM
hconstandt
hconstandt
Srini Dagalur. Applied Clinical Trials 2016
Time squeezing in Clinical Trials
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA = Protocol Approved
FSI = First Site Initiation
LSI = Last Site Initiation
FPI = Frist Patient In
LPI = Last Patient In
LPO = Last Patient Out
DBL = Database Lock
ANL = Analysis Complete
CSR = Clinical Study Report
PA FSI LSI FPI LPI LPO DBL ANL CSR
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR
hconstandt
Srini Dagalur. Applied Clinical Trials 2016
Time squeezing in Clinical Trials
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA = Protocol Approved
FSI = First Site Initiation
LSI = Last Site Initiation
FPI = Frist Patient In
LPI = Last Patient In
LPO = Last Patient Out
DBL = Database Lock
ANL = Analysis Complete
CSR = Clinical Study Report
PA FSI LSI FPI LPI LPO DBL ANL CSR
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR
hconstandt
Srini Dagalur. Applied Clinical Trials 2016
Time squeezing in Clinical Trials
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA = Protocol Approved
FSI = First Site Initiation
LSI = Last Site Initiation
FPI = Frist Patient In
LPI = Last Patient In
LPO = Last Patient Out
DBL = Database Lock
ANL = Analysis Complete
CSR = Clinical Study Report
PA FSI LSI FPI LPI LPO DBL ANL CSR
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR
hconstandt
Srini Dagalur. Applied Clinical Trials 2016
Time squeezing in Clinical Trials
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA = Protocol Approved
FSI = First Site Initiation
LSI = Last Site Initiation
FPI = Frist Patient In
LPI = Last Patient In
LPO = Last Patient Out
DBL = Database Lock
ANL = Analysis Complete
CSR = Clinical Study Report
PA FSI LSI FPI LPI LPO DBL ANL CSR
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR
hconstandt
Srini Dagalur. Applied Clinical Trials 2016
Time squeezing in Clinical Trials
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA = Protocol Approved
FSI = First Site Initiation
LSI = Last Site Initiation
FPI = Frist Patient In
LPI = Last Patient In
LPO = Last Patient Out
DBL = Database Lock
ANL = Analysis Complete
CSR = Clinical Study Report
PA FSI LSI FPI LPI LPO DBL ANL CSR
Protocol
Development
Site
Selection
Site
Initiation
Patient
Recruitment
Study
Conduct
Treatment
Time
Data
Cleaning
Analysis Reporting
Study
Closeout
PA FSI LSI FPI LPI LPO DBL ANL CSR
hconstandt
$134M
hconstandt
ROI & Calculate Value
$807M
hconstandt
ROI of $3.1M
100 USERS
SITE LICENSE
Saving $134M
ENTERPRISE LICENSE
Saving $807M
hconstandt
hconstandt
From Sick Care to HealthCare
The goal of the Web is to serve
humanity. We build it now so
that those who come to it later
will be able to
create things that we
cannot ourselves
imagine
TIM BERNERS LEE
hconstandt
Winning Passionnate Hands-On Genius Team
Excellence - Customer Driven - Respect
Impact – Unconventional - Passionate - Fun
hconstandt
Glad to see Realism coming in &
Value & ROI demonstrated by FAIR Data Fabrics
hconstandt
SKYPE: hansconstandt
TWITTER: hconstandt
LINKEDIN: hansconstandt
booth
#16
hans@ontoforce.com
Hans Constandt Filip Pattyn
filip@ontoforce.com
Martijn Adriaens
martijn@ontoforce.com
Thank You!
Questions?

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ONTOFORCE Talk at PharmaTec London 2019 on the Data Surrealism in times of FAIR data

  • 1. Data Surrealism In Times Of FAIR Data A Pragmatic Approach To Generate More Value With Data Hans Constandt hans@ontoforce.com www.ontoforce.com +32 (0)477 566 102 +1 (415) 996 8988 TWITTER: hconstandt LINKEDIN: hansconstandt
  • 3. How it All Started Source - IDC hconstandt Minimizing Big Data Complexity
  • 4. The Data Tsunami Source - IDC 165 ZETTABYTES BY 2025 hconstandt
  • 5. This is what data looks like THE PROBLEM hconstandt
  • 6. PATIENT-CENTRIC PRECISION MEDICINE CREATES LARGE VOLUMES OF DATA Health Data 300 million books 2020 Medical Data Doubles every 73d Monitoring 1K Readings per Sec Wearables 44ZB by 2020 hconstandt
  • 7. Providing a Complete, Single View of Trusted Data Helping Patients hconstandt
  • 8. Big Data 4 V’s DATA VARIETY & DATA VERACITY VOLUME VELOCIT Y VARIE T Y VERACIT Y Data at rest Data in motion Data in many forms Data In doubt hconstandt
  • 9. Building a Linked Data Fabric PATENTED hconstandt
  • 13. hconstandthconstandtconfidential and not to be shared without consent
  • 14. If I had an hour to solve a problem and my life depended on it, I would use the first 55 minutes determing the proper question to ask ALBERT EINSTEIN hconstandt
  • 15. hconstandt A Self-Service and Collaborative Data Platform for Business Users Saved € 120M in 13 min
  • 16. Management of Corporate Data Assets INSUFFICIENT MANAGEMENT OF INTANGIBLE RESOURCES Source https://www.gartner.com/smarterwithgartner/understanding-the-chief-data-officer-role/ Components of S&P 500 market value hconstandt
  • 18. DATA SWAMP Data Lake Typical Realisation hconstandt
  • 19. You don’t need to be a genius to do Data analytics. Data integration is the key hconstandt
  • 20. the most successful project that uses deep neural networks in there company or group, 10% or less improvement was found over more traditional methods?’ At the Bio-IT World conference 2019 53% of the company’s indicated that… AI REALITY CHECK hconstandt
  • 21. Poor sales ... IBM Watson Health hconstandt
  • 23. 2018: enabling AI/ML functionality automating the fabric. Round A: € 4,3M hconstandt AI
  • 24. Big Data Fabric 2.0 Reference Architecture hconstandt Source: Forrester
  • 25. Solve scalability issues associated with massive linking & inferencing during Data Ingestion User friendliness of ETL process creation Transparency / communicability / auditability of ETL Data Quality Control / validation of data & process Auditability Data Quality Challenges User friendliness Scalability hconstandt
  • 26. Streamlining Data through Pipelines for Faster Analysis hconstandt
  • 27.
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  • 32. Show me the Money hconstandt
  • 33. FAIR DATA Findable Accessible Interoperable Reusable hconstandt
  • 34. FAIR enough to bring value hconstandt
  • 35. ROI of $3.1M 100 USERS SITE LICENSE Saving $134M ENTERPRISE LICENSE Saving $807M hconstandt
  • 37. Solomon Nwaka & Robert G. Ridley. Nature Reviews Drug Discovery 2003 Time squeezing in Discovery Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM IT = Identifiied Target PT = Prioritized Target VT = Validated Target LM = Lead Molecule CM = Candidate Molecule hconstandt
  • 38. Solomon Nwaka & Robert G. Ridley. Nature Reviews Drug Discovery 2003 Time squeezing in Discovery Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM IT = Identifiied Target PT = Prioritized Target VT = Validated Target LM = Lead Molecule CM = Candidate Molecule hconstandt
  • 40. Solomon Nwaka & Robert G. Ridley. Nature Reviews Drug Discovery 2003 Time squeezing in Discovery Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM IT = Identifiied Target PT = Prioritized Target VT = Validated Target LM = Lead Molecule CM = Candidate Molecule hconstandt
  • 41. Solomon Nwaka & Robert G. Ridley. Nature Reviews Drug Discovery 2003 Time squeezing in Discovery Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM IT = Identifiied Target PT = Prioritized Target VT = Validated Target LM = Lead Molecule CM = Candidate Molecule hconstandt
  • 42. Solomon Nwaka & Robert G. Ridley. Nature Reviews Drug Discovery 2003 Time squeezing in Discovery Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM IT = Identifiied Target PT = Prioritized Target VT = Validated Target LM = Lead Molecule CM = Candidate Molecule hconstandt
  • 43. Solomon Nwaka & Robert G. Ridley. Nature Reviews Drug Discovery 2003 Time squeezing in Discovery Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT = Identifiied Target PT = Prioritized Target VT = Validated Target LM = Lead Molecule CM = Candidate Molecule IT PT VT LM CM Target Identification Target Selection Target Validation Lead Identification Lead Optimization Preclinical Development IT PT VT LM CM hconstandt
  • 45. Srini Dagalur. Applied Clinical Trials 2016 Time squeezing in Clinical Trials Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA = Protocol Approved FSI = First Site Initiation LSI = Last Site Initiation FPI = Frist Patient In LPI = Last Patient In LPO = Last Patient Out DBL = Database Lock ANL = Analysis Complete CSR = Clinical Study Report PA FSI LSI FPI LPI LPO DBL ANL CSR Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA FSI LSI FPI LPI LPO DBL ANL CSR hconstandt
  • 46. Srini Dagalur. Applied Clinical Trials 2016 Time squeezing in Clinical Trials Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA = Protocol Approved FSI = First Site Initiation LSI = Last Site Initiation FPI = Frist Patient In LPI = Last Patient In LPO = Last Patient Out DBL = Database Lock ANL = Analysis Complete CSR = Clinical Study Report PA FSI LSI FPI LPI LPO DBL ANL CSR Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA FSI LSI FPI LPI LPO DBL ANL CSR hconstandt
  • 47. Srini Dagalur. Applied Clinical Trials 2016 Time squeezing in Clinical Trials Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA = Protocol Approved FSI = First Site Initiation LSI = Last Site Initiation FPI = Frist Patient In LPI = Last Patient In LPO = Last Patient Out DBL = Database Lock ANL = Analysis Complete CSR = Clinical Study Report PA FSI LSI FPI LPI LPO DBL ANL CSR Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA FSI LSI FPI LPI LPO DBL ANL CSR hconstandt
  • 48. Srini Dagalur. Applied Clinical Trials 2016 Time squeezing in Clinical Trials Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA = Protocol Approved FSI = First Site Initiation LSI = Last Site Initiation FPI = Frist Patient In LPI = Last Patient In LPO = Last Patient Out DBL = Database Lock ANL = Analysis Complete CSR = Clinical Study Report PA FSI LSI FPI LPI LPO DBL ANL CSR Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA FSI LSI FPI LPI LPO DBL ANL CSR hconstandt
  • 49. Srini Dagalur. Applied Clinical Trials 2016 Time squeezing in Clinical Trials Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA = Protocol Approved FSI = First Site Initiation LSI = Last Site Initiation FPI = Frist Patient In LPI = Last Patient In LPO = Last Patient Out DBL = Database Lock ANL = Analysis Complete CSR = Clinical Study Report PA FSI LSI FPI LPI LPO DBL ANL CSR Protocol Development Site Selection Site Initiation Patient Recruitment Study Conduct Treatment Time Data Cleaning Analysis Reporting Study Closeout PA FSI LSI FPI LPI LPO DBL ANL CSR hconstandt
  • 52. ROI of $3.1M 100 USERS SITE LICENSE Saving $134M ENTERPRISE LICENSE Saving $807M hconstandt
  • 53. hconstandt From Sick Care to HealthCare
  • 54. The goal of the Web is to serve humanity. We build it now so that those who come to it later will be able to create things that we cannot ourselves imagine TIM BERNERS LEE hconstandt
  • 55. Winning Passionnate Hands-On Genius Team Excellence - Customer Driven - Respect Impact – Unconventional - Passionate - Fun hconstandt
  • 56. Glad to see Realism coming in & Value & ROI demonstrated by FAIR Data Fabrics hconstandt
  • 57. SKYPE: hansconstandt TWITTER: hconstandt LINKEDIN: hansconstandt booth #16 hans@ontoforce.com Hans Constandt Filip Pattyn filip@ontoforce.com Martijn Adriaens martijn@ontoforce.com Thank You! Questions?